Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 1836871..1837460 | Replicon | chromosome |
Accession | NZ_CP055227 | ||
Organism | Erwinia amylovora strain Ea1189 |
Toxin (Protein)
Gene name | doc | Uniprot ID | D4I2L7 |
Locus tag | GTU81_RS08545 | Protein ID | WP_004157545.1 |
Coordinates | 1837089..1837460 (+) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | D4I2L6 |
Locus tag | GTU81_RS08540 | Protein ID | WP_004157544.1 |
Coordinates | 1836871..1837092 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GTU81_RS08520 | 1832848..1833057 | + | 210 | WP_004157539.1 | glycine zipper 2TM domain-containing protein | - |
GTU81_RS08525 | 1833170..1833646 | + | 477 | WP_004157540.1 | GNAT family N-acetyltransferase | - |
GTU81_RS08530 | 1833770..1834519 | + | 750 | WP_004157541.1 | 5'-nucleotidase, lipoprotein e(P4) family | - |
GTU81_RS08535 | 1834606..1836078 | - | 1473 | WP_004157542.1 | catalase | - |
GTU81_RS08540 | 1836871..1837092 | + | 222 | WP_004157544.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
GTU81_RS08545 | 1837089..1837460 | + | 372 | WP_004157545.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
GTU81_RS08550 | 1838344..1840284 | + | 1941 | WP_004157559.1 | HAMP domain-containing protein | - |
GTU81_RS08555 | 1840410..1841045 | + | 636 | WP_004157562.1 | carbonic anhydrase | - |
GTU81_RS08560 | 1841130..1841579 | - | 450 | WP_004157563.1 | DUF4385 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1822135..1840284 | 18149 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13667.70 Da Isoelectric Point: 7.4182
>T162047 WP_004157545.1 NZ_CP055227:1837089-1837460 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST
Download Length: 372 bp
>T162047 NZ_CP071504:4129065-4130138 [Shewanella sp. FJAT-53726]
ATGGCTGAACGGAATTACAAAAACTTGAACCTTGATCGTGCAGCTATCGATGGCTTGGTGGATAATTTTGCAGCCCAGCA
CCAATTTACCGTTGAATCAATTGGTAATACACCAGGTTCTCAAAATGGAAAGAGGGTCGTTTTTGGTCGAATTGGCACTC
CATATGCGACCGTAAATGTGTTTTTCATCAAAGATGGTACTTCAACCATACAGTTTTTGACTGGTTTGAACCCTGAGCTT
GGAAAGCAATTGGCTGATTATCTTTATGATTCAATAAATCCAGCAGAATTTGAACAAGTTAACATGGTTCTTGAGGGATT
CATTGAGGCCGCTATTTCTCCAGTACTAGATTTAACCGCAGAAGAATCCCATATCCAAGTGGTAGTGCATTCCCATGACG
CAAATAGGATTGTATGGAAAATACAATCGAAAGAGTACCAGGATGAACTTACGGTAACACTTCATATCGGAACACGAAGG
CTTCAAATACAAGGTCGCCCACTTTCATGCTACAGGGTTTTCATCTTCAACCTATCAGAATTACTTGATTTACAAGGATT
AGAAAAGGTTCTCATTAGACAAGAAGATGGTAAGGCTGAAATTGTTCAGCAAGAAGTGGCTCGTTCTTACTTGCGATCAG
TCCTCGGTGAATCTTACGACCAACTGCACTCAAATGTAGAAAAATTGCTCATTTCTGGTCTTTGTGTTAAGCTCGCATCC
CCAAATTTACCTGACTACTGTATGTTGCTTTATCCGGAATTGCGTTCAATTGAAGGTGCTTTAAAGAGTAAATTGAAGGC
TTTTGGTATTGTTGTTGGCAAGGACGGATTTGGTGAATTTTTCGTAAAAGACCAAGGTGTTCATATTTTGAATGCTGATT
GTGCTGCGTCATGTCCAAATGCTGAAGCCGCAAAAGTCATTAGTGAAGCCTATACTTTCTATAATAGAGAGCGTCACGGC
TTATTCCATATGGAAGTACTTGTTGAAGCTAGTCGGGTGATTAGCAACATTACCCATCTCATGACGAAATCGACCCAAGC
TTGGGATCTCATCAAGAAGTTATATACTATTTAA
ATGGCTGAACGGAATTACAAAAACTTGAACCTTGATCGTGCAGCTATCGATGGCTTGGTGGATAATTTTGCAGCCCAGCA
CCAATTTACCGTTGAATCAATTGGTAATACACCAGGTTCTCAAAATGGAAAGAGGGTCGTTTTTGGTCGAATTGGCACTC
CATATGCGACCGTAAATGTGTTTTTCATCAAAGATGGTACTTCAACCATACAGTTTTTGACTGGTTTGAACCCTGAGCTT
GGAAAGCAATTGGCTGATTATCTTTATGATTCAATAAATCCAGCAGAATTTGAACAAGTTAACATGGTTCTTGAGGGATT
CATTGAGGCCGCTATTTCTCCAGTACTAGATTTAACCGCAGAAGAATCCCATATCCAAGTGGTAGTGCATTCCCATGACG
CAAATAGGATTGTATGGAAAATACAATCGAAAGAGTACCAGGATGAACTTACGGTAACACTTCATATCGGAACACGAAGG
CTTCAAATACAAGGTCGCCCACTTTCATGCTACAGGGTTTTCATCTTCAACCTATCAGAATTACTTGATTTACAAGGATT
AGAAAAGGTTCTCATTAGACAAGAAGATGGTAAGGCTGAAATTGTTCAGCAAGAAGTGGCTCGTTCTTACTTGCGATCAG
TCCTCGGTGAATCTTACGACCAACTGCACTCAAATGTAGAAAAATTGCTCATTTCTGGTCTTTGTGTTAAGCTCGCATCC
CCAAATTTACCTGACTACTGTATGTTGCTTTATCCGGAATTGCGTTCAATTGAAGGTGCTTTAAAGAGTAAATTGAAGGC
TTTTGGTATTGTTGTTGGCAAGGACGGATTTGGTGAATTTTTCGTAAAAGACCAAGGTGTTCATATTTTGAATGCTGATT
GTGCTGCGTCATGTCCAAATGCTGAAGCCGCAAAAGTCATTAGTGAAGCCTATACTTTCTATAATAGAGAGCGTCACGGC
TTATTCCATATGGAAGTACTTGTTGAAGCTAGTCGGGTGATTAGCAACATTACCCATCTCATGACGAAATCGACCCAAGC
TTGGGATCTCATCAAGAAGTTATATACTATTTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8173.24 Da Isoelectric Point: 4.9861
>AT162047 WP_004157544.1 NZ_CP055227:1836871-1837092 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR
Download Length: 222 bp
>AT162047 NZ_CP071504:4130140-4130505 [Shewanella sp. FJAT-53726]
ATGTTTAATATCAGGCGGTTAGATTTAGGGTTGAACTCAATAGCTATTGTTACGGCAATTGGCTATGAGAACCCTTTGTC
TTCATTATCTGAAATTGAACATGAATTAACTTGTTTGTTTGGCCAAGAGTTGAATGGTGAAGTAATTTTTGATCTCGTTT
GCTCAAATGGCTTGGAATGGAACCGTTTTATGTCATTACAAATTAAAAACGGTTTCTTCGACTACAATTCTGTTTCGATA
GTAGATAAAACTGATTTACTTCATCAATTGATTGATAAGCAAGCATTTTTCTTAAGTAATAATTTGCACTATCTTCAAGA
ATCTGTACTTACATCTGACGAAATACCTCGAGTTATTGGTGTTTAG
ATGTTTAATATCAGGCGGTTAGATTTAGGGTTGAACTCAATAGCTATTGTTACGGCAATTGGCTATGAGAACCCTTTGTC
TTCATTATCTGAAATTGAACATGAATTAACTTGTTTGTTTGGCCAAGAGTTGAATGGTGAAGTAATTTTTGATCTCGTTT
GCTCAAATGGCTTGGAATGGAACCGTTTTATGTCATTACAAATTAAAAACGGTTTCTTCGACTACAATTCTGTTTCGATA
GTAGATAAAACTGATTTACTTCATCAATTGATTGATAAGCAAGCATTTTTCTTAAGTAATAATTTGCACTATCTTCAAGA
ATCTGTACTTACATCTGACGAAATACCTCGAGTTATTGGTGTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | D4I2L7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831A2K1 |