Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1836871..1837460 Replicon chromosome
Accession NZ_CP055227
Organism Erwinia amylovora strain Ea1189

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag GTU81_RS08545 Protein ID WP_004157545.1
Coordinates 1837089..1837460 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag GTU81_RS08540 Protein ID WP_004157544.1
Coordinates 1836871..1837092 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU81_RS08520 1832848..1833057 + 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -
GTU81_RS08525 1833170..1833646 + 477 WP_004157540.1 GNAT family N-acetyltransferase -
GTU81_RS08530 1833770..1834519 + 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
GTU81_RS08535 1834606..1836078 - 1473 WP_004157542.1 catalase -
GTU81_RS08540 1836871..1837092 + 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTU81_RS08545 1837089..1837460 + 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GTU81_RS08550 1838344..1840284 + 1941 WP_004157559.1 HAMP domain-containing protein -
GTU81_RS08555 1840410..1841045 + 636 WP_004157562.1 carbonic anhydrase -
GTU81_RS08560 1841130..1841579 - 450 WP_004157563.1 DUF4385 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1822135..1840284 18149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T162047 WP_004157545.1 NZ_CP055227:1837089-1837460 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

>T162047 NZ_CP071504:4129065-4130138 [Shewanella sp. FJAT-53726]
ATGGCTGAACGGAATTACAAAAACTTGAACCTTGATCGTGCAGCTATCGATGGCTTGGTGGATAATTTTGCAGCCCAGCA
CCAATTTACCGTTGAATCAATTGGTAATACACCAGGTTCTCAAAATGGAAAGAGGGTCGTTTTTGGTCGAATTGGCACTC
CATATGCGACCGTAAATGTGTTTTTCATCAAAGATGGTACTTCAACCATACAGTTTTTGACTGGTTTGAACCCTGAGCTT
GGAAAGCAATTGGCTGATTATCTTTATGATTCAATAAATCCAGCAGAATTTGAACAAGTTAACATGGTTCTTGAGGGATT
CATTGAGGCCGCTATTTCTCCAGTACTAGATTTAACCGCAGAAGAATCCCATATCCAAGTGGTAGTGCATTCCCATGACG
CAAATAGGATTGTATGGAAAATACAATCGAAAGAGTACCAGGATGAACTTACGGTAACACTTCATATCGGAACACGAAGG
CTTCAAATACAAGGTCGCCCACTTTCATGCTACAGGGTTTTCATCTTCAACCTATCAGAATTACTTGATTTACAAGGATT
AGAAAAGGTTCTCATTAGACAAGAAGATGGTAAGGCTGAAATTGTTCAGCAAGAAGTGGCTCGTTCTTACTTGCGATCAG
TCCTCGGTGAATCTTACGACCAACTGCACTCAAATGTAGAAAAATTGCTCATTTCTGGTCTTTGTGTTAAGCTCGCATCC
CCAAATTTACCTGACTACTGTATGTTGCTTTATCCGGAATTGCGTTCAATTGAAGGTGCTTTAAAGAGTAAATTGAAGGC
TTTTGGTATTGTTGTTGGCAAGGACGGATTTGGTGAATTTTTCGTAAAAGACCAAGGTGTTCATATTTTGAATGCTGATT
GTGCTGCGTCATGTCCAAATGCTGAAGCCGCAAAAGTCATTAGTGAAGCCTATACTTTCTATAATAGAGAGCGTCACGGC
TTATTCCATATGGAAGTACTTGTTGAAGCTAGTCGGGTGATTAGCAACATTACCCATCTCATGACGAAATCGACCCAAGC
TTGGGATCTCATCAAGAAGTTATATACTATTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT162047 WP_004157544.1 NZ_CP055227:1836871-1837092 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp

>AT162047 NZ_CP071504:4130140-4130505 [Shewanella sp. FJAT-53726]
ATGTTTAATATCAGGCGGTTAGATTTAGGGTTGAACTCAATAGCTATTGTTACGGCAATTGGCTATGAGAACCCTTTGTC
TTCATTATCTGAAATTGAACATGAATTAACTTGTTTGTTTGGCCAAGAGTTGAATGGTGAAGTAATTTTTGATCTCGTTT
GCTCAAATGGCTTGGAATGGAACCGTTTTATGTCATTACAAATTAAAAACGGTTTCTTCGACTACAATTCTGTTTCGATA
GTAGATAAAACTGATTTACTTCATCAATTGATTGATAAGCAAGCATTTTTCTTAAGTAATAATTTGCACTATCTTCAAGA
ATCTGTACTTACATCTGACGAAATACCTCGAGTTATTGGTGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References