Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1838973..1839562 Replicon chromosome
Accession NZ_CP117554
Organism Erwinia amylovora strain 99east-3-1

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag PTC76_RS08575 Protein ID WP_004157545.1
Coordinates 1839191..1839562 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag PTC76_RS08570 Protein ID WP_004157544.1
Coordinates 1838973..1839194 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC76_RS08550 (PTC76_08550) 1834950..1835159 + 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -
PTC76_RS08555 (PTC76_08555) 1835272..1835748 + 477 WP_004157540.1 GNAT family N-acetyltransferase -
PTC76_RS08560 (PTC76_08560) 1835872..1836621 + 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
PTC76_RS08565 (PTC76_08565) 1836708..1838180 - 1473 WP_004157542.1 catalase -
PTC76_RS08570 (PTC76_08570) 1838973..1839194 + 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTC76_RS08575 (PTC76_08575) 1839191..1839562 + 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PTC76_RS08580 (PTC76_08580) 1840446..1842386 + 1941 WP_004157559.1 methyl-accepting chemotaxis protein -
PTC76_RS08585 (PTC76_08585) 1842512..1843147 + 636 WP_004157562.1 carbonic anhydrase -
PTC76_RS08590 (PTC76_08590) 1843232..1843681 - 450 WP_004157563.1 DUF4385 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1824237..1842386 18149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T271325 WP_004157545.1 NZ_CP117554:1839191-1839562 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT271325 WP_004157544.1 NZ_CP117554:1838973-1839194 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References