Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 632543..633132 Replicon chromosome
Accession NZ_CP076591
Organism Erwinia amylovora isolate CP201142

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag KQH37_RS02775 Protein ID WP_004157545.1
Coordinates 632543..632914 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag KQH37_RS02780 Protein ID WP_004157544.1
Coordinates 632911..633132 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH37_RS02760 (KQH37_02795) 628424..628873 + 450 WP_004157563.1 DUF4385 domain-containing protein -
KQH37_RS02765 (KQH37_02800) 628958..629593 - 636 WP_004157562.1 carbonic anhydrase -
KQH37_RS02770 (KQH37_02805) 629719..631659 - 1941 WP_004157559.1 methyl-accepting chemotaxis protein -
KQH37_RS02775 (KQH37_02810) 632543..632914 - 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KQH37_RS02780 (KQH37_02815) 632911..633132 - 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KQH37_RS02785 (KQH37_02820) 633925..635397 + 1473 WP_004157542.1 catalase -
KQH37_RS02790 (KQH37_02825) 635484..636233 - 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
KQH37_RS02795 (KQH37_02830) 636357..636833 - 477 WP_004157540.1 GNAT family N-acetyltransferase -
KQH37_RS02800 (KQH37_02835) 636946..637155 - 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 632543..648804 16261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T205983 WP_004157545.1 NZ_CP076591:c632914-632543 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

>T205983 NZ_CP101989:3725970-3726410 [Cellulomonas wangsupingiae]
GTGACGGCTGAACCCTGCTACCTGCTCGACGTGAACGTCCTCCTCGCGCTGGCCGCCGACGCGCACGTGCACCATCGCGC
CGCGCACCGGTGGTTCGCCGACGTCACGGCGTGGGCCACGACCCCGGTCACCGAGTCGGCGTTCGTGCGCCTGCTGTCCA
CCCCGGCCGTTCTCGGTCGGACGGTCCTTCCCATCGAGGCGGTCGCGGCGCTGCGGCAGATGCGGACGGTCCCGGGTCAC
CGCTTCCTCCCGGACGACGCGTCGTTCGCGGACACCACGATCGACCTGACGCGCATGGTCGGACCGCGCCAGGTCACCGA
CTTCCACCTCGTCGGGCTCGCGCGCCGCACCGGCAGCACGCTCGCGACGCTCGATGCCAAGCTCCGTCGATCGCTCCACC
CGGCAGACGCCCACCTCGTGAGCGTCGTCCCCGCGGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT205983 WP_004157544.1 NZ_CP076591:c633132-632911 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp

>AT205983 NZ_CP101989:3725762-3725980 [Cellulomonas wangsupingiae]
ATGAGGACGACGCTCGAGATCGACGACCGGGTGCTGGCCGCCGCGCGCGCGATCGCCGAGCAGCAGAACGTGTCGATCGG
ACGCGCGATCTCCGACCTCGCCGAGCGTGCCCTCGAGGGCACCGCGCCCGCGTCGACCGTCCGGGGGTTCCCGGTCTTCC
ACGGCCCGGCGGGCCACGTGATCACCGACGAGATGGTCGCCGAGCACCGTGACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References