Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1838784..1839373 Replicon chromosome
Accession NZ_CP066794
Organism Erwinia amylovora strain 17-2187

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag JGC41_RS08560 Protein ID WP_004157545.1
Coordinates 1839002..1839373 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag JGC41_RS08555 Protein ID WP_004157544.1
Coordinates 1838784..1839005 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC41_RS08535 1834761..1834970 + 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -
JGC41_RS08540 1835083..1835559 + 477 WP_004157540.1 GNAT family N-acetyltransferase -
JGC41_RS08545 1835683..1836432 + 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
JGC41_RS08550 1836519..1837991 - 1473 WP_004157542.1 catalase -
JGC41_RS08555 1838784..1839005 + 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JGC41_RS08560 1839002..1839373 + 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JGC41_RS08565 1840257..1842197 + 1941 WP_004157559.1 HAMP domain-containing protein -
JGC41_RS08570 1842323..1842958 + 636 WP_004157562.1 carbonic anhydrase -
JGC41_RS08575 1843043..1843492 - 450 WP_004157563.1 DUF4385 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1824048..1842197 18149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T185031 WP_004157545.1 NZ_CP066794:1839002-1839373 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

>T185031 NZ_CP087880:c2855951-2855553 [Pseudocitrobacter corydidari]
ATGCGGGTGTTCAAAACGAAGCTGATTCGCCTTCAGCTTACCGAGAAGGAACTTGCGGCACTAACGGCGGATTTCATCTC
CTATAAACGAGATGGAATATTACCTGACATTTCTGGACGTGATGCTGCATACGACAGCCCGTACACCTGGCCGTTGGTTA
AATCAGAGCGCGTAGCGCACATTCACCTGGCGTCAGCAGAGAAGCCTTTCCCACCGCAGTTGCGGCAATTCAACAGAACG
AATGACGAAGCGCATCTGGTCTATTGTCAGGGCGCATTTGATGAACAGGCGTGGCTGTTGATCGCCATTCTGAAACCGCA
GCCTCATCAGCAGGCGCGTGATAATAATCAAATGCAGAAAATTGGCAAAATGGCAGAAGCATTCCGCATGCGTTTTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT185031 WP_004157544.1 NZ_CP066794:1838784-1839005 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp

>AT185031 NZ_CP087880:c2856247-2855954 [Pseudocitrobacter corydidari]
ATGCATCGAATTCTTGCGGAAAAATCTGTCAATATCACGGAGTTACGAAAAAATCCGGCCAGATACTTTATCGATCAACC
TGTTGCGGTTCTGTCGAATAACAAACCCGCAGGCTATTTGTTAAGCGCCAGCGTATTTGAGGCGTTAATGGATTTACTCG
CTGAGCATCAGGACGTAAAAAATGTCACCGCCCAGTTTCGCCCCAGCGCCGCAAGGTTAGAGGAAATGACGCGCCGTGCA
GAACGCTACCTCAATGATGTAACGGATGATGATTTAAATGACTTTAAGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References