24677

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1835946..1836535 Replicon chromosome
Accession NC_013961
Organism Erwinia amylovora CFBP1430

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag EAMY_RS25625 Protein ID WP_004157545.1
Coordinates 1836164..1836535 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag EAMY_RS25620 Protein ID WP_004157544.1
Coordinates 1835946..1836167 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAMY_RS35010 1831923..1832132 + 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -
EAMY_RS25605 1832245..1832721 + 477 WP_004157540.1 GNAT family N-acetyltransferase -
EAMY_RS25610 1832845..1833594 + 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
EAMY_RS25615 1833681..1835153 - 1473 WP_004157542.1 catalase -
EAMY_RS25620 1835946..1836167 + 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EAMY_RS25625 1836164..1836535 + 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
EAMY_RS25630 1837419..1839359 + 1941 WP_004157559.1 HAMP domain-containing protein -
EAMY_RS25635 1839485..1840120 + 636 WP_004157562.1 carbonic anhydrase -
EAMY_RS25640 1840205..1840654 - 450 WP_004157563.1 DUF4385 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1821210..1839359 18149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T24677 WP_004157545.1 NC_013961:1836164-1836535 [Erwinia amylovora CFBP1430]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

>T24677 NC_013961:1836164-1836535 [Erwinia amylovora CFBP1430]
ATGATTTATTTTCTATCCAGTCAAGACATCATCGGCATTCATCAGCGTATGATCGTCGCTTACGGCGGTCTTGCCGGTTA
TGCCGATCCTGGTCGGATAGAAAGTATGGCAACACGGATTCTGAACCGCCACATCTACGAAGGTGAGGATGATATCTATA
TTCTGGCAGCTGCATATCTGCTGGCCATTGCGCGCGGGCATTGTTTCAATGATGCAAATAAGAGAACCGCATTTGCTTCA
ACTGCTTTATTCCTGCGCCGTAATGGCATTCTTCTTCGCTTTTCCCCAATCCATGAACAGCTGACTGTCTCAGCAGCACA
GGGGAGCCTGGATGTGTGGCACATTGCTGAAGCACTGAAACAGTCGACATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT24677 WP_004157544.1 NC_013961:1835946-1836167 [Erwinia amylovora CFBP1430]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp

>AT24677 NC_013961:1835946-1836167 [Erwinia amylovora CFBP1430]
ATGCAAGCTATAAACTTTACTACCGCCCGTAACGAACTGGCATCAGTTCTTGATAGCGTTGCCAGCGGTGAGCCAGTTAT
GATCACCCGCAGATCGGCCAAATCCGTGGTTGTGGTTGATGCCGCGCAGTATGAAAAAATGCAAAAAATTCAGGCAGAAT
CGGACTTTGATTGGTTGTTTACAGAACATGGCCAGACGCTTGAAGCTCTTAAAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References