Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1838788..1839377 Replicon chromosome
Accession NZ_CP056034
Organism Erwinia amylovora strain TS3128

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag HU055_RS08555 Protein ID WP_004157545.1
Coordinates 1839006..1839377 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag HU055_RS08550 Protein ID WP_004157544.1
Coordinates 1838788..1839009 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU055_RS08530 1834765..1834974 + 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -
HU055_RS08535 1835087..1835563 + 477 WP_004157540.1 GNAT family N-acetyltransferase -
HU055_RS08540 1835687..1836436 + 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
HU055_RS08545 1836523..1837995 - 1473 WP_004157542.1 catalase -
HU055_RS08550 1838788..1839009 + 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HU055_RS08555 1839006..1839377 + 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HU055_RS08560 1840261..1842201 + 1941 WP_004157559.1 HAMP domain-containing protein -
HU055_RS08565 1842327..1842962 + 636 WP_004157562.1 carbonic anhydrase -
HU055_RS08570 1843047..1843496 - 450 WP_004157563.1 DUF4385 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1829180..1842201 13021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T162507 WP_004157545.1 NZ_CP056034:1839006-1839377 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

>T162507 NZ_CP071822:58218-58370 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATTGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT162507 WP_004157544.1 NZ_CP056034:1838788-1839009 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp

>AT162507 NZ_CP071822:c58166-58106 [Klebsiella pneumoniae subsp. pneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References