Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1613325..1613914 Replicon chromosome
Accession NZ_CP076590
Organism Erwinia amylovora isolate CP200930

Toxin (Protein)


Gene name doc Uniprot ID D4I2L7
Locus tag KQH39_RS07630 Protein ID WP_004157545.1
Coordinates 1613543..1613914 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID D4I2L6
Locus tag KQH39_RS07625 Protein ID WP_004157544.1
Coordinates 1613325..1613546 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH39_RS07605 (KQH39_07595) 1609302..1609511 + 210 WP_004157539.1 glycine zipper 2TM domain-containing protein -
KQH39_RS07610 (KQH39_07600) 1609624..1610100 + 477 WP_004157540.1 GNAT family N-acetyltransferase -
KQH39_RS07615 (KQH39_07605) 1610224..1610973 + 750 WP_004157541.1 5'-nucleotidase, lipoprotein e(P4) family -
KQH39_RS07620 (KQH39_07610) 1611060..1612532 - 1473 WP_004157542.1 catalase -
KQH39_RS07625 (KQH39_07615) 1613325..1613546 + 222 WP_004157544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KQH39_RS07630 (KQH39_07620) 1613543..1613914 + 372 WP_004157545.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KQH39_RS07635 (KQH39_07625) 1614798..1616738 + 1941 WP_004157559.1 methyl-accepting chemotaxis protein -
KQH39_RS07640 (KQH39_07630) 1616864..1617499 + 636 WP_004157562.1 carbonic anhydrase -
KQH39_RS07645 (KQH39_07635) 1617584..1618033 - 450 WP_004157563.1 DUF4385 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1603717..1616738 13021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13667.70 Da        Isoelectric Point: 7.4182

>T205976 WP_004157545.1 NZ_CP076590:1613543-1613914 [Erwinia amylovora]
MIYFLSSQDIIGIHQRMIVAYGGLAGYADPGRIESMATRILNRHIYEGEDDIYILAAAYLLAIARGHCFNDANKRTAFAS
TALFLRRNGILLRFSPIHEQLTVSAAQGSLDVWHIAEALKQST

Download         Length: 372 bp

>T205976 NZ_CP101985:c1371864-1371673 [Streptococcus mutans]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGAAAGTCATCA
TGATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8173.24 Da        Isoelectric Point: 4.9861

>AT205976 WP_004157544.1 NZ_CP076590:1613325-1613546 [Erwinia amylovora]
MQAINFTTARNELASVLDSVASGEPVMITRRSAKSVVVVDAAQYEKMQKIQAESDFDWLFTEHGQTLEALKNR

Download         Length: 222 bp

>AT205976 NZ_CP101985:c1371655-1371278 [Streptococcus mutans]
ATGTTAAAATCATATCCTGCAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTAGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACTGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAAGCTTTGGAAAGGAAACTACAATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4I2L7

Antitoxin

Source ID Structure
AlphaFold DB A0A831A2K1

References