Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGC/cglC   Type   Machinery gene
Locus tag   R8522_RS10450 Genome accession   NZ_AP026916
Coordinates   2021096..2021422 (-) Length   108 a.a.
NCBI ID   WP_000738624.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700006     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2016096..2026422
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8522_RS10405 (PC0006_20790) rnpA 2016120..2016491 (-) 372 WP_000739246.1 ribonuclease P protein component -
  R8522_RS10410 - 2016508..2016639 (-) 132 WP_000768904.1 hypothetical protein -
  R8522_RS10415 (PC0006_20800) - 2016640..2017830 (-) 1191 WP_000167759.1 acetate kinase -
  R8522_RS10420 (PC0006_20810) comYH 2017881..2018834 (-) 954 WP_000345123.1 class I SAM-dependent methyltransferase Machinery gene
  R8522_RS10425 (PC0006_20820) - 2018895..2019482 (-) 588 WP_000679774.1 class I SAM-dependent methyltransferase -
  R8522_RS10430 (PC0006_20830) comGG/cglG 2019619..2020032 (-) 414 WP_000265630.1 competence type IV pilus minor pilin ComGG Machinery gene
  R8522_RS10435 comGF/cglF 2020010..2020471 (-) 462 WP_000250548.1 competence type IV pilus minor pilin ComGF Machinery gene
  R8522_RS10440 (PC0006_20850) comGE/cglE 2020434..2020736 (-) 303 WP_000413380.1 competence type IV pilus minor pilin ComGE Machinery gene
  R8522_RS10445 (PC0006_20860) comGD/cglD 2020699..2021103 (-) 405 WP_000588007.1 competence type IV pilus minor pilin ComGD Machinery gene
  R8522_RS10450 (PC0006_20870) comGC/cglC 2021096..2021422 (-) 327 WP_000738624.1 competence type IV pilus major pilin ComGC Machinery gene
  R8522_RS10455 (PC0006_20880) comGB/cglB 2021424..2022440 (-) 1017 WP_078140087.1 competence type IV pilus assembly protein ComGB Machinery gene
  R8522_RS10460 (PC0006_20890) comGA/cglA/cilD 2022388..2023329 (-) 942 WP_000249549.1 competence type IV pilus ATPase ComGA Machinery gene
  R8522_RS10465 (PC0006_20900) - 2023405..2023770 (-) 366 WP_000286415.1 DUF1033 family protein -
  R8522_RS10470 (PC0006_20910) - 2023921..2024979 (-) 1059 WP_000649471.1 zinc-dependent alcohol dehydrogenase family protein -
  R8522_RS10475 (PC0006_20920) nagA 2025142..2026293 (-) 1152 WP_001134454.1 N-acetylglucosamine-6-phosphate deacetylase -

Sequence

Protein


Download         Length: 108 a.a.        Molecular weight: 12227.44 Da        Isoelectric Point: 9.9664

>NTDB_id=97676 R8522_RS10450 WP_000738624.1 2021096..2021422(-) (comGC/cglC) [Streptococcus pneumoniae strain PZ900700006]
MKKMMTFLKKAKVKAFTLVEMLVVLLIISVLFLLFVPNLAKQKEAVNDKGKAAVVKVVESQAELYSLEKNEDASLSKLKE
DGRITEEQAKAYKEYNDKNVGANRKVYD

Nucleotide


Download         Length: 327 bp        

>NTDB_id=97676 R8522_RS10450 WP_000738624.1 2021096..2021422(-) (comGC/cglC) [Streptococcus pneumoniae strain PZ900700006]
ATGAAAAAAATGATGACATTCTTGAAAAAAGCTAAGGTTAAAGCTTTTACATTGGTGGAAATGTTGGTGGTCTTGCTGAT
TATCAGCGTGCTTTTCTTGCTCTTTGTACCTAATCTGGCCAAGCAAAAAGAAGCAGTCAATGACAAAGGAAAAGCAGCTG
TTGTTAAGGTGGTGGAAAGCCAGGCAGAACTTTATAGCTTGGAAAAGAATGAAGATGCTAGCCTAAGCAAGTTAAAAGAA
GATGGACGCATCACGGAAGAACAGGCTAAAGCTTATAAAGAATACAATGATAAAAATGTAGGAGCAAATCGTAAAGTCTA
TGATTAA

Domains

Predicted by InterproScan.

Prokaryotic N-terminal methylation motif (N_methyl)

(11-34)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGC/cglC Streptococcus pneumoniae TIGR4

94.444

100

0.944
  comGC/cglC Streptococcus pneumoniae Rx1

93.519

100

0.935
  comGC/cglC Streptococcus pneumoniae D39

93.519

100

0.935
  comGC/cglC Streptococcus pneumoniae R6

93.519

100

0.935
  comGC/cglC Streptococcus mitis SK321

90.741

100

0.907
  comGC/cglC Streptococcus mitis NCTC 12261

92.857

90.741

0.843
  comYC Streptococcus gordonii str. Challis substr. CH1

70.833

88.889

0.63
  comYC Streptococcus mutans UA159

61.765

94.444

0.583
  comYC Streptococcus mutans UA140

61.765

94.444

0.583
  comGC Lactococcus lactis subsp. cremoris KW2

54.902

94.444

0.519
  comYC Streptococcus suis isolate S10

67.901

75

0.509
  comGC Staphylococcus aureus MW2

50

79.63

0.398
  comGC Staphylococcus aureus N315

50

79.63

0.398
  comGC Latilactobacillus sakei subsp. sakei 23K

45.349

79.63

0.361

Multiple sequence alignment