Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   R4700_RS05550 Genome accession   NZ_CP137112
Coordinates   1078701..1079453 (-) Length   250 a.a.
NCBI ID   WP_000866075.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 02H2025     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 1073383..1078441 1078701..1079453 flank 260


Gene organization within MGE regions


Location: 1073383..1079453
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4700_RS05520 - 1073383..1074636 (+) 1254 WP_000649625.1 IS110 family transposase -
  R4700_RS05525 - 1074896..1075438 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  R4700_RS05540 - 1075745..1076698 (-) 954 WP_001155321.1 IS30-like element ISSpn8 family transposase -
  R4700_RS05545 - 1077044..1078441 (+) 1398 WP_050279859.1 ISNCY-like element IS1202 family transposase -
  R4700_RS05550 comE 1078701..1079453 (-) 753 WP_000866075.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29930.26 Da        Isoelectric Point: 6.5073

>NTDB_id=896039 R4700_RS05550 WP_000866075.1 1078701..1079453(-) (comE) [Streptococcus pneumoniae strain 02H2025]
MKVLILEDVIEHQVRLERILDEISKESNTPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQISALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHAQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=896039 R4700_RS05550 WP_000866075.1 1078701..1079453(-) (comE) [Streptococcus pneumoniae strain 02H2025]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATACTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTTGCTCAACTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTGACCTATAAATACCAGATATCAGCCCTAGATTT
TGTTGATAAGGATATCAACGATGAGATGTTTAAGAAGCGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATGCTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

98.8

100

0.988
  comE Streptococcus pneumoniae D39

98.8

100

0.988
  comE Streptococcus pneumoniae R6

98.8

100

0.988
  comE Streptococcus pneumoniae TIGR4

98.8

100

0.988
  comE Streptococcus mitis SK321

98

100

0.98
  comE Streptococcus mitis NCTC 12261

97.2

100

0.972
  comE Streptococcus infantis strain Atu-4

90

100

0.9
  comE/comE2 Streptococcus gordonii strain NCTC7865

62.4

100

0.624
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

62.4

100

0.624
  comE/blpR Streptococcus mutans UA159

40.891

98.8

0.404