Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   N8I78_RS02260 Genome accession   NZ_CP106757
Coordinates   473412..474710 (-) Length   432 a.a.
NCBI ID   WP_002406460.1    Uniprot ID   A0A855UIE9
Organism   Enterococcus faecalis strain NY13410     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 468412..479710
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  N8I78_RS02225 (N8I78_02225) - 468654..469385 (+) 732 WP_002387356.1 GntR family transcriptional regulator -
  N8I78_RS02230 (N8I78_02230) - 469400..469810 (+) 411 WP_002359084.1 PTS sugar transporter subunit IIA -
  N8I78_RS02235 (N8I78_02235) - 469822..470565 (+) 744 WP_002387355.1 BtpA/SgcQ family protein -
  N8I78_RS02240 (N8I78_02240) - 470568..471041 (+) 474 WP_002359087.1 PTS sugar transporter subunit IIB -
  N8I78_RS02245 (N8I78_02245) - 471063..471833 (+) 771 WP_002359088.1 PTS sugar transporter subunit IIC -
  N8I78_RS02250 (N8I78_02250) - 471817..472641 (+) 825 WP_002385250.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  N8I78_RS02255 (N8I78_02255) ytpR 472745..473365 (+) 621 WP_002361057.1 YtpR family tRNA-binding protein -
  N8I78_RS02260 (N8I78_02260) htrA 473412..474710 (-) 1299 WP_002406460.1 trypsin-like peptidase domain-containing protein Regulator
  N8I78_RS02265 (N8I78_02265) rlmH 475111..475590 (+) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44861.98 Da        Isoelectric Point: 4.9968

>NTDB_id=734545 N8I78_RS02260 WP_002406460.1 473412..474710(-) (htrA) [Enterococcus faecalis strain NY13410]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPTSVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=734545 N8I78_RS02260 WP_002406460.1 473412..474710(-) (htrA) [Enterococcus faecalis strain NY13410]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCCCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACATCCACTAATCACGGCGACACAAAAGTCAGCAATGTAAGTTACAATGTGTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGAAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCAATTG
GTTCCCCTCTAGGCTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCTATTCAAACCGATGCTGCCATCAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGAATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTCGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAACTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACTATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

Peptidase family M50 (Peptidase_M50)

(9-416)

PDZ domain (PDZ_2)

(319-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A855UIE9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

94.907

0.505
  htrA Streptococcus mutans UA159

58.63

84.491

0.495
  htrA Streptococcus mitis NCTC 12261

55.135

85.648

0.472
  htrA Streptococcus pneumoniae TIGR4

55.807

81.713

0.456
  htrA Streptococcus pneumoniae Rx1

55.807

81.713

0.456
  htrA Streptococcus pneumoniae D39

55.807

81.713

0.456
  htrA Streptococcus pneumoniae R6

55.807

81.713

0.456