Detailed information NTG0055537

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: SMUNUM_RS04520
• Genome accession: NZ_AP014571
• Coordinates: 910222..912327 (-)
• Length: 701 a.a.
• NCBI ID: WP_002262823.1
• Uniprot ID: Q8DUH3
• Organism: Streptococcus mutans LP13
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 905222..917327

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUNUM_RS04500 (SMNUM_0842)	mmuM	906337..907287 (+)	951	WP_002269978.1	homocysteine S-methyltransferase	-
SMUNUM_RS04505 (SMNUM_0843)	-	907421..908683 (-)	1263	WP_002263804.1	PLP-dependent aminotransferase family protein	-
SMUNUM_RS04510 (SMNUM_0844)	-	908781..909632 (+)	852	WP_019318799.1	pyridoxamine kinase	-
SMUNUM_RS04515 (SMNUM_0845)	-	909629..910162 (+)	534	WP_002266931.1	ECF transporter S component	-
SMUNUM_RS04520 (SMNUM_0846)	clpC	910222..912327 (-)	2106	WP_002262823.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SMUNUM_RS04525 (SMNUM_0847)	rplJ	912722..913225 (+)	504	WP_002262824.1	50S ribosomal protein L10	-
SMUNUM_RS04530 (SMNUM_0848)	rplL	913291..913659 (+)	369	WP_002262825.1	50S ribosomal protein L7/L12	-
SMUNUM_RS04535 (SMNUM_0849)	-	913926..914477 (+)	552	WP_002262826.1	carboxymuconolactone decarboxylase family protein	-
SMUNUM_RS04540 (SMNUM_0850)	-	914498..915565 (+)	1068	WP_002262827.1	acyl-CoA dehydrogenase family protein	-
SMUNUM_RS04545 (SMNUM_0851)	-	916157..917056 (-)	900	WP_002305733.1	polysaccharide deacetylase family protein	-

Sequence

Protein

• Length: 701 a.a.
• Molecular weight: 77185.93 Da
• Isoelectric Point: 4.7315

>NTDB_id=55537 SMUNUM_RS04520 WP_002262823.1 910222..912327(-) (clpC) [Streptococcus mutans LP13]
MANFNGRDPFGNMDDIFNQLMGNMGGYNSENRRYLINGREVSPEEFAQYRQTGKLPGNPEIQQAQAAARTPKEDSILTKL
GNNLTEEARQGNLDPVIGRNKEIQETAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPASIKNKEVISIDISG
LEAGTQYRGAFEENIQNLVKEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADIIKPALSRGELTVIGATTQDEYRNT
IMKNAALARRFNEVKVNAPSAEDTYEILKGISALYEQHHNVILPKEVLKAAVDLSVQYIPQRSLPDKAIDLVDMTAAHLA
AQHPATDVKTLEKEIQTEKDKQQAAAEKEDYEEALKSKTKIDKLQAQIDNHTEGQKVTATINDVAEAVERLTGIPVSQMG
SSDIERLKEMNSRLKGKVIGQDEAVEAVSRAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDSIIRL
DMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIVLLDEIEKADSQVITLLLQVLDDGRLTDGQGNTINFKN
TVIIATSNAGFGNEALTGQEDKDMKIMDRIAPYFRPEFLNRFNAVIEFSHLSKEDLDEIVNLMLSEVNTTLAKKGIDLVV
SDSAKAHLIEEGYDEAMGVRPLRRVIEQEIRDKVTDFYLDHTDVKHLKAEMQDDKLIIEEA

Nucleotide

• Length: 2106 bp

>NTDB_id=55537 SMUNUM_RS04520 WP_002262823.1 910222..912327(-) (clpC) [Streptococcus mutans LP13]
ATGGCAAATTTTAATGGACGCGATCCTTTTGGAAATATGGACGATATTTTTAATCAATTAATGGGTAATATGGGGGGATA
CAACTCTGAAAACCGTCGATATTTAATTAACGGTCGTGAAGTAAGTCCCGAAGAATTCGCACAATACAGACAAACAGGTA
AGCTTCCTGGCAATCCAGAAATACAGCAAGCTCAAGCTGCTGCTAGAACTCCAAAAGAAGACAGTATTTTGACTAAGCTT
GGTAACAATTTAACCGAAGAAGCCAGACAAGGTAACCTTGATCCTGTTATTGGACGGAATAAAGAAATTCAAGAAACTGC
TGAGATCTTAGCTCGGCGGACTAAAAACAATCCTGTTCTGGTCGGTGATGCCGGTGTTGGTAAAACAGCTGTCGTTGAAG
GCTTAGCACAGGCTATTGTTAACGGTGATGTCCCTGCCAGTATTAAAAATAAGGAAGTTATTTCTATTGATATTTCAGGA
TTAGAAGCTGGTACACAATACCGTGGTGCTTTCGAAGAAAATATTCAAAACTTGGTTAAAGAAGTCAAAGAAGCTGGCAA
TATCATCCTCTTCTTTGATGAAATTCATCAAATTTTAGGTGCTGGTTCAACTGGTGGTGACAGTGGTTCTAAAGGTTTGG
CAGACATTATCAAACCTGCTTTATCTCGCGGTGAATTGACTGTTATCGGTGCTACTACGCAAGATGAATACCGCAATACC
ATTATGAAAAACGCTGCATTGGCACGTCGTTTCAACGAAGTCAAAGTAAATGCACCTTCTGCTGAGGATACTTACGAAAT
TTTAAAAGGTATTTCAGCTCTCTACGAACAACATCATAATGTTATTTTGCCTAAGGAAGTTTTAAAAGCTGCTGTTGACT
TATCCGTACAATACATTCCACAACGCAGTCTGCCTGATAAGGCCATTGACCTTGTTGATATGACAGCTGCTCATCTGGCT
GCTCAACATCCAGCAACTGATGTTAAGACACTTGAAAAAGAAATTCAAACTGAAAAAGATAAACAACAAGCTGCTGCTGA
AAAAGAAGATTATGAGGAAGCTCTTAAATCAAAAACTAAAATTGATAAACTGCAAGCACAAATTGACAATCATACTGAAG
GGCAAAAGGTCACTGCTACTATCAACGATGTGGCTGAGGCAGTTGAACGTTTGACAGGTATCCCTGTTTCGCAAATGGGA
AGCAGTGACATTGAACGTCTAAAAGAAATGAATTCTCGTCTCAAAGGCAAAGTTATTGGTCAAGATGAAGCTGTTGAAGC
TGTTTCACGCGCTATTCGCCGTAACCGTGCTGGTTTTGATGAAGGCAACCGTCCAATCGGCAGTTTCCTTTTTGTTGGAC
CTACTGGTGTTGGTAAAACAGAATTGGCTAAGCAGTTAGCCTTGGATATGTTTGGTTCTAAAGACTCTATTATCCGTCTT
GATATGTCAGAGTACAGTGATCGTACAGCTGTTTCCAAATTGATTGGTACTACTGCCGGTTATGTCGGCTATGATGATAA
CAGCAATACATTGACTGAACGTGTTCGCCGCAATCCTTATTCTATCGTTTTACTTGATGAGATTGAAAAGGCTGACTCTC
AAGTCATCACTCTTCTCCTTCAAGTATTGGATGATGGTCGTTTGACAGACGGACAAGGTAATACCATTAACTTTAAGAAT
ACCGTGATTATTGCAACTTCTAATGCTGGTTTTGGTAATGAAGCCTTAACTGGTCAGGAAGATAAGGACATGAAGATCAT
GGATCGCATTGCCCCTTACTTCCGTCCCGAGTTTTTAAACCGTTTCAATGCAGTCATTGAATTCTCTCACTTAAGCAAAG
AAGACTTGGATGAAATTGTTAATCTCATGCTATCTGAAGTGAATACCACGCTTGCTAAGAAAGGAATTGATCTTGTTGTC
AGTGACAGCGCCAAGGCACATTTGATTGAAGAAGGTTATGACGAAGCAATGGGTGTTCGTCCATTACGCCGAGTTATCGA
GCAAGAAATTCGTGATAAAGTAACTGACTTCTATCTTGATCATACAGATGTTAAACATCTCAAAGCTGAAATGCAAGATG
ATAAATTGATTATTGAAGAAGCTTAA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (119-251)

• AAA domain (Cdc48 subfamily) (AAA_2) (444-604)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

• AAA lid domain (AAA_lid_9) (260-356)

3D structure

• AlphaFold DB: Q8DUH3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	47.795	100	0.479
clpE	Streptococcus pneumoniae Rx1	46.901	100	0.475
clpE	Streptococcus pneumoniae D39	46.901	100	0.475
clpE	Streptococcus pneumoniae R6	46.901	100	0.475
clpE	Streptococcus pneumoniae TIGR4	46.942	100	0.471
clpE	Streptococcus mutans UA159	46.781	99.715	0.466
clpC	Bacillus subtilis subsp. subtilis str. 168	43.388	96.006	0.417
clpC	Streptococcus pneumoniae Rx1	44.098	87.019	0.384
clpC	Streptococcus pneumoniae D39	44.098	87.019	0.384
clpC	Streptococcus pneumoniae TIGR4	43.934	87.019	0.382
clpC	Streptococcus thermophilus LMD-9	42.673	88.588	0.378
clpC	Streptococcus mutans UA159	42.88	88.16	0.378
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.332	89.301	0.378
clpC	Streptococcus thermophilus LMG 18311	42.351	88.588	0.375