Detailed information NTG0418219

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: M594_RS00065
• Genome accession: NZ_CP047883
• Coordinates: 14251..14730 (+)
• Length: 159 a.a.
• NCBI ID: WP_173875630.1
• Uniprot ID: A0A6M9EXJ4
• Organism: Streptococcus mitis strain S022-V3-A4
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 9251..19730

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M594_RS00050 (M594_00050)	tilS	10332..11609 (+)	1278	WP_173875628.1	tRNA lysidine(34) synthetase TilS	-
M594_RS00055 (M594_00055)	hpt	11614..12156 (+)	543	WP_125452616.1	hypoxanthine phosphoribosyltransferase	-
M594_RS00060 (M594_00060)	ftsH	12172..14130 (+)	1959	WP_173875629.1	ATP-dependent zinc metalloprotease FtsH	-
M594_RS00065 (M594_00065)	comX/sigX/comX2/sigX2	14251..14730 (+)	480	WP_173875630.1	sigma-70 family RNA polymerase sigma factor	Regulator

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19853.48 Da
• Isoelectric Point: 7.3196

>NTDB_id=418219 M594_RS00065 WP_173875630.1 14251..14730(+) (comX/sigX/comX2/sigX2) [Streptococcus mitis strain S022-V3-A4]
MFKELYEEVQGIVYKSRNEYYLHLWELSDWDQEGMICLHELISSEEGLVEDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLCLDDYYLFHETLRDYRNKQSKDKQEELERVLRNERFRGRQRVLRDLRIVFKEFDIRTR

Nucleotide

• Length: 480 bp

>NTDB_id=418219 M594_RS00065 WP_173875630.1 14251..14730(+) (comX/sigX/comX2/sigX2) [Streptococcus mitis strain S022-V3-A4]
ATGTTTAAAGAATTATATGAAGAAGTCCAGGGAATTGTATATAAGAGTAGAAATGAATATTACTTGCATTTATGGGAATT
ATCGGATTGGGACCAAGAGGGTATGATTTGCTTACATGAATTGATCAGTAGCGAAGAAGGGCTTGTAGAAGATATTCCAC
GTTTAAGGAAATATTTTAAGACTAAGTTCCGGAATCGAATTCTAGACTATATCCGTAAGCAAGAAAGTCAGAAGCGTAGA
TATGATAAAGAACCCTATGAAGAAGTAGGTGAGATTAGTCATCGTATAAGTGAGGGAGGTCTGTGTCTAGATGATTATTA
TCTCTTTCATGAGACACTAAGAGATTATAGAAACAAACAAAGTAAAGACAAACAAGAAGAGTTAGAACGCGTCTTAAGAA
ATGAACGCTTCCGAGGGCGTCAAAGAGTATTAAGGGACTTACGTATTGTGTTTAAGGAATTTGATATCCGTACTCGGTAA

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A6M9EXJ4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	94.34	100	0.943
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	94.937	99.371	0.943
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	94.937	99.371	0.943
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	93.711	100	0.937
comX/comX2	Streptococcus pneumoniae R6	93.671	99.371	0.931
comX/comX1	Streptococcus pneumoniae R6	93.671	99.371	0.931
comX/comX1	Streptococcus pneumoniae D39	93.671	99.371	0.931
comX/comX2	Streptococcus pneumoniae Rx1	93.671	99.371	0.931
comX/comX1	Streptococcus pneumoniae Rx1	93.671	99.371	0.931
comX/comX2	Streptococcus pneumoniae D39	93.671	99.371	0.931
comX/comX2	Streptococcus pneumoniae TIGR4	93.038	99.371	0.925
comX/comX1	Streptococcus pneumoniae TIGR4	93.038	99.371	0.925
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	49.359	98.113	0.484
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	49.359	98.113	0.484
comX/sigX	Streptococcus suis D9	45.752	96.226	0.44
comX/sigX	Streptococcus suis isolate S10	45.752	96.226	0.44
comX/sigX	Streptococcus suis P1/7	45.752	96.226	0.44
comX/sigX	Streptococcus mutans UA159	45.752	96.226	0.44
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	41.611	93.711	0.39
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	41.611	93.711	0.39
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	41.611	93.711	0.39
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	41.611	93.711	0.39
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	40.789	95.597	0.39
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	40.789	95.597	0.39
comX	Streptococcus salivarius SK126	38.065	97.484	0.371
comX	Streptococcus thermophilus LMG 18311	38.065	97.484	0.371
comX	Streptococcus thermophilus LMD-9	38.065	97.484	0.371
comX/sigX	Streptococcus salivarius strain HSISS4	37.419	97.484	0.365