Detailed information NTG0027499

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: SSA_RS01085
• Genome accession: NC_009009
• Coordinates: 190201..190518 (+)
• Length: 105 a.a.
• NCBI ID: WP_011836360.1
• Uniprot ID: A3CKE3
• Organism: Streptococcus sanguinis SK36
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 185201..195518

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSA_RS01065 (SSA_0182)	-	186361..187467 (+)	1107	WP_033179098.1	glycosyl hydrolase family 8	-
SSA_RS01070 (SSA_0183)	-	187786..188166 (+)	381	WP_011836357.1	DUF1033 family protein	-
SSA_RS01075 (SSA_0184)	comYA	188296..189237 (+)	942	WP_011836358.1	competence type IV pilus ATPase ComGA	Machinery gene
SSA_RS01080 (SSA_0185)	comYB	189167..190201 (+)	1035	WP_260469263.1	competence type IV pilus assembly protein ComGB	Machinery gene
SSA_RS01085 (SSA_0186)	comYC	190201..190518 (+)	318	WP_011836360.1	competence type IV pilus major pilin ComGC	Machinery gene
SSA_RS01090 (SSA_0187)	comYD	190478..190912 (+)	435	WP_033179099.1	competence type IV pilus minor pilin ComGD	Machinery gene
SSA_RS01095 (SSA_0188)	comGE/cglE	190878..191171 (+)	294	WP_033179100.1	competence type IV pilus minor pilin ComGE	Machinery gene
SSA_RS01100 (SSA_0189)	comGF/cglF	191155..191583 (+)	429	WP_011836363.1	competence type IV pilus minor pilin ComGF	Machinery gene
SSA_RS01105 (SSA_0190)	comGG	191573..191965 (+)	393	WP_033179101.1	competence type IV pilus minor pilin ComGG	-
SSA_RS01110 (SSA_0191)	comYH	192047..193012 (+)	966	WP_002910847.1	class I SAM-dependent methyltransferase	Machinery gene
SSA_RS01115 (SSA_0192)	-	193049..194242 (+)	1194	WP_002911070.1	acetate kinase	-
SSA_RS01120 (SSA_0193)	-	194386..195135 (+)	750	WP_033179102.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 105 a.a.
• Molecular weight: 11434.29 Da
• Isoelectric Point: 9.6959

>NTDB_id=27499 SSA_RS01085 WP_011836360.1 190201..190518(+) (comYC) [Streptococcus sanguinis SK36]
MKKFNTLKVQAFTLVEMLIVLLVISVLLLLFVPNLTKQKDAVSDTGTAAVVKVVESQAELYELKNTNEKASLSKLVSAGN
ISQKQADSYKAYYGKHSGETQAVAN

Nucleotide

• Length: 318 bp

>NTDB_id=27499 SSA_RS01085 WP_011836360.1 190201..190518(+) (comYC) [Streptococcus sanguinis SK36]
ATGAAAAAATTTAATACCTTAAAAGTTCAAGCATTTACCCTTGTGGAAATGCTGATTGTCTTGCTGGTTATCAGCGTACT
CTTGCTGCTCTTTGTGCCTAATCTGACCAAGCAAAAAGATGCTGTTTCAGATACAGGAACTGCAGCAGTGGTCAAGGTGG
TAGAAAGCCAGGCGGAGCTGTATGAACTAAAGAATACCAATGAAAAGGCTAGCCTGAGCAAGCTGGTCAGTGCAGGAAAT
ATCAGCCAGAAACAGGCAGATTCTTATAAGGCTTACTATGGAAAACACAGTGGCGAAACTCAAGCGGTTGCCAATTAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (9-30)

3D structure

• AlphaFold DB: A3CKE3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus gordonii str. Challis substr. CH1	81.905	100	0.819
comYC	Streptococcus mutans UA159	68.571	100	0.686
comYC	Streptococcus mutans UA140	68.571	100	0.686
comGC/cglC	Streptococcus mitis NCTC 12261	65.138	100	0.676
comGC/cglC	Streptococcus mitis SK321	65.421	100	0.667
comGC/cglC	Streptococcus pneumoniae Rx1	63.551	100	0.648
comGC/cglC	Streptococcus pneumoniae D39	63.551	100	0.648
comGC/cglC	Streptococcus pneumoniae TIGR4	63.551	100	0.648
comGC/cglC	Streptococcus pneumoniae R6	63.551	100	0.648
comGC	Lactococcus lactis subsp. cremoris KW2	58	95.238	0.552
comYC	Streptococcus suis isolate S10	60.674	84.762	0.514
comGC	Staphylococcus aureus MW2	43.878	93.333	0.41
comGC	Staphylococcus aureus N315	43.878	93.333	0.41