Detailed information NTG0239370

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: CGZ53_RS02025
• Genome accession: NZ_CP022435
• Coordinates: 376861..377349 (+)
• Length: 162 a.a.
• NCBI ID: WP_012657889.1
• Uniprot ID: A0A2X4EEE3
• Organism: Streptococcus uberis strain NZ01
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 371861..382349

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CGZ53_RS02025 (CGZ53_02020)	comX/sigX/comX2/sigX2	376861..377349 (+)	489	WP_012657889.1	sigma-70 family RNA polymerase sigma factor	Regulator
CGZ53_RS02030 (CGZ53_02025)	-	377583..378110 (+)	528	WP_012657890.1	YqeG family HAD IIIA-type phosphatase	-
CGZ53_RS02035 (CGZ53_02030)	yqeH	378110..379228 (+)	1119	WP_012657891.1	ribosome biogenesis GTPase YqeH	-
CGZ53_RS02040 (CGZ53_02035)	yhbY	379283..379591 (+)	309	WP_012657892.1	ribosome assembly RNA-binding protein YhbY	-
CGZ53_RS02045 (CGZ53_02040)	-	379655..380287 (+)	633	WP_012657893.1	nicotinate-nucleotide adenylyltransferase	-
CGZ53_RS02050 (CGZ53_02045)	yqeK	380284..380877 (+)	594	WP_100911921.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
CGZ53_RS02055 (CGZ53_02050)	rsfS	380887..381240 (+)	354	WP_012657895.1	ribosome silencing factor	-
CGZ53_RS02060 (CGZ53_02055)	-	381291..382031 (+)	741	WP_012657896.1	class I SAM-dependent DNA methyltransferase	-

Sequence

Protein

• Length: 162 a.a.
• Molecular weight: 19529.52 Da
• Isoelectric Point: 8.4931

>NTDB_id=239370 CGZ53_RS02025 WP_012657889.1 376861..377349(+) (comX/sigX/comX2/sigX2) [Streptococcus uberis strain NZ01]
MFNHDFENCFEQVLPIILKLKRSFYIQLWDRDDWLQEGRIILHHLMEDNPDLADNRMKLLCYFKTKFTSHIKDTLRYQES
AKRRFNRLPYDEIGDVSHKIAEDGLKLDDIVAFHTILNHLTPKLSENEMNQIQALFSNKRFSGRKKLLRKLKPFFVDFQD
NL

Nucleotide

• Length: 489 bp

>NTDB_id=239370 CGZ53_RS02025 WP_012657889.1 376861..377349(+) (comX/sigX/comX2/sigX2) [Streptococcus uberis strain NZ01]
ATGTTTAATCATGATTTTGAAAACTGTTTTGAACAAGTATTACCAATTATTTTGAAATTGAAAAGAAGTTTTTATATACA
ATTATGGGATAGAGATGATTGGTTACAAGAAGGCCGGATTATTTTACATCATCTAATGGAGGATAATCCTGACTTAGCAG
ATAATAGAATGAAACTACTATGCTATTTTAAAACAAAGTTTACATCACATATTAAAGATACTTTAAGGTACCAAGAAAGT
GCTAAGAGGAGATTTAACAGATTGCCATATGATGAAATTGGGGATGTATCACATAAAATTGCAGAGGATGGTTTAAAACT
CGATGATATAGTTGCCTTCCATACCATTTTGAACCACCTAACTCCCAAACTTTCCGAAAACGAAATGAATCAGATTCAAG
CGTTGTTTAGTAATAAAAGATTTTCAGGCCGTAAAAAACTATTACGGAAGTTAAAACCTTTTTTTGTTGATTTCCAGGAT
AATTTATAG

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A2X4EEE3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	54.545	95.062	0.519
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	54.545	95.062	0.519
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	54.545	95.062	0.519
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	54.545	95.062	0.519
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	53.896	95.062	0.512
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	53.896	95.062	0.512
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	43.59	96.296	0.42
comX/sigX	Streptococcus mutans UA159	40.252	98.148	0.395
comX	Streptococcus sobrinus strain NIDR 6715-7	39.13	99.383	0.389
comX/sigX	Streptococcus suis D9	40	95.679	0.383
comX/sigX	Streptococcus suis isolate S10	40	95.679	0.383
comX/sigX	Streptococcus suis P1/7	40	95.679	0.383
comX/comX2	Streptococcus pneumoniae Rx1	40.94	91.975	0.377
comX/comX2	Streptococcus pneumoniae TIGR4	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae TIGR4	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae Rx1	40.94	91.975	0.377
comX/comX2	Streptococcus pneumoniae D39	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae D39	40.94	91.975	0.377
comX/comX2	Streptococcus pneumoniae R6	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae R6	40.94	91.975	0.377
comX	Streptococcus thermophilus LMG 18311	39.869	94.444	0.377
comX	Streptococcus thermophilus LMD-9	39.869	94.444	0.377
comX	Streptococcus salivarius SK126	39.216	94.444	0.37
comX/sigX	Streptococcus salivarius strain HSISS4	39.216	94.444	0.37
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	38.562	94.444	0.364
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	38.562	94.444	0.364
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	38.562	94.444	0.364