Detailed information NTG1170408

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: ACLV7W_RS00070
• Genome accession: NZ_OZ217346
• Coordinates: 14251..14730 (+)
• Length: 159 a.a.
• NCBI ID: WP_153209010.1
• Uniprot ID: A0A6I1UHB2
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 9251..19730

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS00055 (SMID22_00110)	tilS	10331..11608 (+)	1278	WP_411865214.1	tRNA lysidine(34) synthetase TilS	-
ACLV7W_RS00060 (SMID22_00120)	hpt	11613..12155 (+)	543	WP_153209006.1	hypoxanthine phosphoribosyltransferase	-
ACLV7W_RS00065 (SMID22_00130)	ftsH	12171..14129 (+)	1959	WP_153209008.1	ATP-dependent zinc metalloprotease FtsH	-
ACLV7W_RS00070 (SMID22_00140)	comX/sigX/comX2/sigX2	14251..14730 (+)	480	WP_153209010.1	sigma-70 family RNA polymerase sigma factor	Regulator

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 20083.89 Da
• Isoelectric Point: 8.4254

>NTDB_id=1170408 ACLV7W_RS00070 WP_153209010.1 14251..14730(+) (comX/sigX/comX2/sigX2) [Streptococcus mitis isolate S. mitis D22]
MLKKLYEEVQGIVYKCRNEYYLHLWELSDWDQEGMICLHELISREEELVEDIPRLRKYFKTKFRNRILDHIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDEYYLFHETLRDYRNKQSKEKQEELERILRHERFRGRQRVLRDLRIVFKEFDIRSR

Nucleotide

• Length: 480 bp

>NTDB_id=1170408 ACLV7W_RS00070 WP_153209010.1 14251..14730(+) (comX/sigX/comX2/sigX2) [Streptococcus mitis isolate S. mitis D22]
ATGCTTAAAAAATTGTATGAAGAAGTCCAAGGAATTGTATACAAGTGTAGAAATGAATATTACCTTCATTTATGGGAGTT
ATCGGATTGGGACCAAGAGGGAATGATCTGCTTACATGAATTGATCAGTAGAGAAGAAGAACTGGTAGAAGATATTCCAC
GCTTACGTAAATATTTCAAGACTAAGTTTCGTAATCGAATTTTAGACCATATCCGTAAACAAGAAAGTCAGAAGCGTAGA
TATGATAAAGAACCTTATGAAGAAGTGGGAGAGATTAGTCATCGTATCAGTGAGGGAGGTCTGTGGCTAGATGAGTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGCAAAGAGAAGCAAGAAGAGTTAGAACGCATCTTAAGAC
ATGAACGCTTCCGAGGGCGTCAAAGAGTTCTAAGGGACTTGCGTATTGTGTTTAAAGAGTTTGATATCCGTAGTCGGTAA

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A6I1UHB2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	96.203	99.371	0.956
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	93.671	99.371	0.931
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	91.824	100	0.918
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	91.824	100	0.918
comX/comX1	Streptococcus pneumoniae D39	91.772	99.371	0.912
comX/comX2	Streptococcus pneumoniae R6	91.772	99.371	0.912
comX/comX1	Streptococcus pneumoniae R6	91.772	99.371	0.912
comX/comX2	Streptococcus pneumoniae Rx1	91.772	99.371	0.912
comX/comX1	Streptococcus pneumoniae Rx1	91.772	99.371	0.912
comX/comX2	Streptococcus pneumoniae D39	91.772	99.371	0.912
comX/comX2	Streptococcus pneumoniae TIGR4	91.139	99.371	0.906
comX/comX1	Streptococcus pneumoniae TIGR4	91.139	99.371	0.906
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	50.98	96.226	0.491
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	50.98	96.226	0.491
comX/sigX	Streptococcus mutans UA159	48	94.34	0.453
comX/sigX	Streptococcus suis D9	45.752	96.226	0.44
comX/sigX	Streptococcus suis isolate S10	45.752	96.226	0.44
comX/sigX	Streptococcus suis P1/7	45.752	96.226	0.44
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.953	93.711	0.403
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.953	93.711	0.403
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.953	93.711	0.403
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.953	93.711	0.403
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42.105	95.597	0.403
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42.105	95.597	0.403
comX	Streptococcus thermophilus LMG 18311	38.816	95.597	0.371
comX	Streptococcus thermophilus LMD-9	38.816	95.597	0.371
comX	Streptococcus salivarius SK126	39.333	94.34	0.371
comX/sigX	Streptococcus salivarius strain HSISS4	38.667	94.34	0.365