Detailed information NTG1140493

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: DQN33_RS02010
• Genome accession: NZ_LS483408
• Coordinates: 397304..397792 (+)
• Length: 162 a.a.
• NCBI ID: WP_012657889.1
• Uniprot ID: A0A2X4EEE3
• Organism: Streptococcus uberis strain NCTC4674
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 392304..402792

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN33_RS02010 (NCTC4674_00415)	comX/sigX/comX2/sigX2	397304..397792 (+)	489	WP_012657889.1	sigma-70 family RNA polymerase sigma factor	Regulator
DQN33_RS02015 (NCTC4674_00416)	-	398026..398553 (+)	528	WP_111673073.1	YqeG family HAD IIIA-type phosphatase	-
DQN33_RS02020 (NCTC4674_00417)	yqeH	398553..399671 (+)	1119	WP_012657891.1	ribosome biogenesis GTPase YqeH	-
DQN33_RS02025 (NCTC4674_00418)	yhbY	399726..400034 (+)	309	WP_012657892.1	ribosome assembly RNA-binding protein YhbY	-
DQN33_RS02030 (NCTC4674_00419)	-	400098..400730 (+)	633	WP_012657893.1	nicotinate-nucleotide adenylyltransferase	-
DQN33_RS02035 (NCTC4674_00420)	yqeK	400727..401320 (+)	594	WP_012657894.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
DQN33_RS02040 (NCTC4674_00421)	rsfS	401330..401683 (+)	354	WP_012657895.1	ribosome silencing factor	-
DQN33_RS02045 (NCTC4674_00422)	-	401734..402474 (+)	741	WP_012657896.1	class I SAM-dependent DNA methyltransferase	-

Sequence

Protein

• Length: 162 a.a.
• Molecular weight: 19529.52 Da
• Isoelectric Point: 8.4931

>NTDB_id=1140493 DQN33_RS02010 WP_012657889.1 397304..397792(+) (comX/sigX/comX2/sigX2) [Streptococcus uberis strain NCTC4674]
MFNHDFENCFEQVLPIILKLKRSFYIQLWDRDDWLQEGRIILHHLMEDNPDLADNRMKLLCYFKTKFTSHIKDTLRYQES
AKRRFNRLPYDEIGDVSHKIAEDGLKLDDIVAFHTILNHLTPKLSENEMNQIQALFSNKRFSGRKKLLRKLKPFFVDFQD
NL

Nucleotide

• Length: 489 bp

>NTDB_id=1140493 DQN33_RS02010 WP_012657889.1 397304..397792(+) (comX/sigX/comX2/sigX2) [Streptococcus uberis strain NCTC4674]
ATGTTTAATCATGATTTTGAAAACTGTTTTGAACAAGTATTACCAATTATTTTGAAATTGAAAAGAAGTTTTTATATACA
ATTATGGGATAGAGATGATTGGTTACAAGAAGGCCGGATTATTTTACATCATCTAATGGAGGATAATCCTGACTTAGCAG
ATAATAGAATGAAACTACTATGCTATTTTAAAACAAAGTTTACATCACATATTAAAGATACTTTAAGGTACCAAGAAAGT
GCTAAGAGGAGATTTAACAGATTGCCATATGATGAAATTGGGGATGTATCACATAAAATTGCAGAGGATGGTTTAAAACT
CGATGATATAGTTGCCTTCCATACCATTTTGAACCACCTAACTCCCAAACTTTCCGAAAACGAAATGAATCAGATTCAAG
CGTTGTTTAGTAATAAAAGATTTTCAGGCCGTAAAAAACTATTACGGAAGTTAAAACCTTTTTTTGTTGATTTCCAGGAT
AATTTATAG

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A2X4EEE3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	54.545	95.062	0.519
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	54.545	95.062	0.519
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	54.545	95.062	0.519
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	54.545	95.062	0.519
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	53.896	95.062	0.512
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	53.896	95.062	0.512
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	43.59	96.296	0.42
comX/sigX	Streptococcus mutans UA159	40.252	98.148	0.395
comX	Streptococcus sobrinus strain NIDR 6715-7	39.13	99.383	0.389
comX/sigX	Streptococcus suis D9	40	95.679	0.383
comX/sigX	Streptococcus suis isolate S10	40	95.679	0.383
comX/sigX	Streptococcus suis P1/7	40	95.679	0.383
comX/comX2	Streptococcus pneumoniae Rx1	40.94	91.975	0.377
comX/comX2	Streptococcus pneumoniae TIGR4	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae TIGR4	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae Rx1	40.94	91.975	0.377
comX/comX2	Streptococcus pneumoniae D39	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae D39	40.94	91.975	0.377
comX/comX2	Streptococcus pneumoniae R6	40.94	91.975	0.377
comX/comX1	Streptococcus pneumoniae R6	40.94	91.975	0.377
comX	Streptococcus thermophilus LMG 18311	39.869	94.444	0.377
comX	Streptococcus thermophilus LMD-9	39.869	94.444	0.377
comX	Streptococcus salivarius SK126	39.216	94.444	0.37
comX/sigX	Streptococcus salivarius strain HSISS4	39.216	94.444	0.37
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	38.562	94.444	0.364
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	38.562	94.444	0.364
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	38.562	94.444	0.364