Detailed information NTG1139656

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: DQM63_RS10550
• Genome accession: NZ_LS483385
• Coordinates: 2115324..2115641 (-)
• Length: 105 a.a.
• NCBI ID: WP_002896769.1
• Uniprot ID: F3SKF6
• Organism: Streptococcus sanguinis strain NCTC7863
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2110324..2120641

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM63_RS10515 (NCTC7863_02075)	-	2110719..2111468 (-)	750	WP_032909647.1	CPBP family intramembrane glutamic endopeptidase	-
DQM63_RS10520 (NCTC7863_02076)	-	2111603..2112796 (-)	1194	WP_002901705.1	acetate kinase	-
DQM63_RS10525 (NCTC7863_02077)	comYH	2112833..2113798 (-)	966	WP_002901707.1	class I SAM-dependent methyltransferase	Machinery gene
DQM63_RS10530 (NCTC7863_02078)	comGG	2113880..2114269 (-)	390	WP_002901710.1	competence type IV pilus minor pilin ComGG	-
DQM63_RS10535 (NCTC7863_02079)	comGF/cglF	2114250..2114687 (-)	438	WP_002901713.1	competence type IV pilus minor pilin ComGF	Machinery gene
DQM63_RS10540 (NCTC7863_02080)	comGE/cglE	2114671..2114964 (-)	294	WP_002914478.1	competence type IV pilus minor pilin ComGE	Machinery gene
DQM63_RS10545 (NCTC7863_02081)	comYD	2114930..2115364 (-)	435	WP_002901717.1	competence type IV pilus minor pilin ComGD	Machinery gene
DQM63_RS10550 (NCTC7863_02082)	comYC	2115324..2115641 (-)	318	WP_002896769.1	competence type IV pilus major pilin ComGC	Machinery gene
DQM63_RS10555 (NCTC7863_02083)	comYB	2115641..2116675 (-)	1035	WP_263281106.1	competence type IV pilus assembly protein ComGB	Machinery gene
DQM63_RS10560 (NCTC7863_02084)	comYA	2116605..2117546 (-)	942	WP_002901721.1	competence type IV pilus ATPase ComGA	Machinery gene
DQM63_RS10565 (NCTC7863_02085)	-	2117676..2118056 (-)	381	WP_002901723.1	DUF1033 family protein	-
DQM63_RS10575 (NCTC7863_02086)	-	2118375..2119481 (-)	1107	WP_002901727.1	glycosyl hydrolase family 8	-

Sequence

Protein

• Length: 105 a.a.
• Molecular weight: 11400.28 Da
• Isoelectric Point: 9.6959

>NTDB_id=1139656 DQM63_RS10550 WP_002896769.1 2115324..2115641(-) (comYC) [Streptococcus sanguinis strain NCTC7863]
MKKLNTLKVQAFTLVEMLIVLLVISVLLLLFVPNLTKQKDAVSDTGTAAVVKVVESQAELYELKNTNEKASLSKLVSAGN
ISQKQADSYKAYYGKHSGETQAVAN

Nucleotide

• Length: 318 bp

>NTDB_id=1139656 DQM63_RS10550 WP_002896769.1 2115324..2115641(-) (comYC) [Streptococcus sanguinis strain NCTC7863]
ATGAAAAAACTTAATACCTTAAAAGTTCAAGCATTCACCCTTGTGGAAATGCTGATTGTCTTGCTGGTTATCAGCGTACT
CTTGCTGCTCTTTGTGCCTAATCTGACCAAGCAAAAAGATGCTGTTTCAGATACAGGAACTGCAGCGGTGGTCAAGGTAG
TAGAAAGCCAGGCGGAGCTGTATGAACTGAAGAATACCAATGAAAAGGCTAGCCTGAGCAAGCTAGTCAGTGCAGGAAAT
ATCAGCCAGAAACAGGCAGATTCTTATAAGGCTTACTATGGAAAACACAGTGGCGAAACTCAAGCGGTTGCCAATTAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (9-30)

3D structure

• AlphaFold DB: F3SKF6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus gordonii str. Challis substr. CH1	82.857	100	0.829
comYC	Streptococcus mutans UA159	68.571	100	0.686
comYC	Streptococcus mutans UA140	68.571	100	0.686
comGC/cglC	Streptococcus mitis NCTC 12261	65.138	100	0.676
comGC/cglC	Streptococcus mitis SK321	65.421	100	0.667
comGC/cglC	Streptococcus pneumoniae Rx1	63.551	100	0.648
comGC/cglC	Streptococcus pneumoniae D39	63.551	100	0.648
comGC/cglC	Streptococcus pneumoniae TIGR4	63.551	100	0.648
comGC/cglC	Streptococcus pneumoniae R6	63.551	100	0.648
comGC	Lactococcus lactis subsp. cremoris KW2	59	95.238	0.562
comYC	Streptococcus suis isolate S10	61.798	84.762	0.524
comGC	Staphylococcus aureus MW2	43.878	93.333	0.41
comGC	Staphylococcus aureus N315	43.878	93.333	0.41