Detailed information NTG1007305

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: ABLU27_RS12135
• Genome accession: NZ_CP157500
• Coordinates: 2346424..2347116 (-)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis strain 2B-9
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 2341424..2352116

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABLU27_RS12120 (ABLU27_12105)	-	2343043..2343384 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
ABLU27_RS12125 (ABLU27_12110)	-	2343516..2344757 (-)	1242	WP_058212572.1	ammonium transporter	-
ABLU27_RS12130 (ABLU27_12115)	covS	2344940..2346415 (-)	1476	WP_406834513.1	ATP-binding protein	Regulator
ABLU27_RS12135 (ABLU27_12120)	covR	2346424..2347116 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
ABLU27_RS12140 (ABLU27_12125)	-	2347272..2347802 (-)	531	WP_058212571.1	DUF177 domain-containing protein	-
ABLU27_RS12145 (ABLU27_12130)	-	2347933..2348178 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
ABLU27_RS12150 (ABLU27_12135)	-	2348334..2348798 (-)	465	WP_058212570.1	hypothetical protein	-
ABLU27_RS12155 (ABLU27_12140)	-	2348880..2349242 (-)	363	WP_010906050.1	TIGR02328 family protein	-
ABLU27_RS12160 (ABLU27_12145)	-	2349727..2350224 (-)	498	WP_406834514.1	CHAP domain-containing protein	-
ABLU27_RS12165 (ABLU27_12150)	-	2350318..2351154 (-)	837	WP_023164354.1	metallophosphoesterase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=1007305 ABLU27_RS12135 WP_003130756.1 2346424..2347116(-) (covR) [Lactococcus lactis strain 2B-9]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=1007305 ABLU27_RS12135 WP_003130756.1 2346424..2347116(-) (covR) [Lactococcus lactis strain 2B-9]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCACGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361