Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB-PIN
Location 473953..474432 Replicon chromosome
Accession NC_000911
Organism Synechocystis sp. PCC 6803

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ssl2923 Protein ID WP_010871640.1
Coordinates 473953..474204 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ssl2922 Protein ID WP_010871641.1
Coordinates 474205..474432 (-) Length 76 a.a.

Genomic Context

SGL_RS04110SGL_RS04115SGL_RS04120SGL_RS04105SGL_RS04125SGL_RS04130SGL_RS04135SGL_RS04140SGL_RS04145SGL_RS04150SGL_RS04155
Location: 469592..470914 (1323 bp)
Type: Others
Protein ID: WP_010871637.1
Location: 471080..472930 (1851 bp)
Type: Others
Protein ID: WP_010871638.1
Location: 473088..473675 (588 bp)
Type: Others
Protein ID: Protein_446
Location: 469001..469546 (546 bp)
Type: Others
Protein ID: WP_010871636.1
Location: 473953..474204 (252 bp)
Type: Toxin
Protein ID: WP_010871640.1
Location: 474205..474432 (228 bp)
Type: Antitoxin
Protein ID: WP_010871641.1
Location: 474511..474792 (282 bp)
Type: Others
Protein ID: WP_020861443.1
Location: 474789..475007 (219 bp)
Type: Others
Protein ID: WP_010871642.1
Location: 475110..475445 (336 bp)
Type: Others
Protein ID: WP_010871643.1
Location: 475435..475743 (309 bp)
Type: Others
Protein ID: WP_010871644.1
Location: 475873..477399 (1527 bp)
Type: Others
Protein ID: WP_010871645.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SGL_RS04105 (sll1507)469001..469546-546WP_010871636.1alpha/beta hydrolase-
SGL_RS04110 (slr1603)469592..470914+1323WP_010871637.1hypothetical protein-
SGL_RS04115 (slr1604)471080..472930+1851WP_010871638.1ATP-dependent zinc metalloprotease FtsH3-
SGL_RS04120473088..473675+588Protein_446IS5 family transposase-
SGL_RS04125 (ssl2923)473953..474204-252WP_010871640.1type II toxin-antitoxin system VapC family toxinToxin
SGL_RS04130 (ssl2922)474205..474432-228WP_010871641.1virulence factorAntitoxin
SGL_RS04135474511..474792-282WP_020861443.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
SGL_RS04140 (ssl2920)474789..475007-219WP_010871642.1hypothetical protein-
SGL_RS04145 (sll1505)475110..475445-336WP_010871643.1DUF86 domain-containing protein-
SGL_RS04150 (sll1504)475435..475743-309WP_010871644.1nucleotidyltransferase family protein-
SGL_RS04155 (sll1503)475873..477399-1527WP_010871645.1RNA-directed DNA polymerase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--473414..473662248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9540.13 Da        Isoelectric Point: 7.9952

>T962 WP_010871640.1 NC_000911:c474204-473953 [Synechocystis sp. PCC 6803]
MKYLLDTNICIYLIKKKPFKVLAKFQTLEISDIGISSITVAELEYGVSKSQQQSKNRDALMQFLMPLEIVEFNSGSGDRL
WQH

Download         Length: 252 bp

>T962 NC_000911:c474204-473953 [Synechocystis sp. PCC 6803]
ATGAAGTATTTACTAGATACGAATATTTGCATTTATCTCATTAAGAAGAAACCGTTTAAAGTCTTGGCAAAATTTCAAAC
CCTGGAGATATCAGACATTGGTATTTCATCCATTACCGTGGCGGAATTAGAATATGGTGTCAGTAAAAGTCAACAACAAT
CGAAAAATCGTGATGCCTTAATGCAATTCTTGATGCCGCTAGAAATCGTGGAATTTAATTCAGGAAGCGGCGATCGCCTA
TGGCAACATTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8538.69 Da        Isoelectric Point: 4.2840

>AT962 WP_010871641.1 NC_000911:c474432-474205 [Synechocystis sp. PCC 6803]
MNTAQISTDGTHQIVILPENFTIAGSEVYIKKIGSTIILIAKNNPWQSLIESLDQFSDDFMKTREQPPLDIREEF

Download         Length: 228 bp

>AT962 NC_000911:c474432-474205 [Synechocystis sp. PCC 6803]
ATGAACACAGCTCAAATTAGCACCGATGGCACCCATCAAATCGTTATTTTACCAGAAAACTTTACGATAGCCGGAAGCGA
AGTTTACATTAAAAAAATTGGAAGTACAATTATTTTGATTGCTAAAAATAACCCTTGGCAATCCTTAATTGAAAGCTTAG
ATCAATTTTCAGATGATTTTATGAAAACTAGGGAACAGCCTCCCTTAGATATACGAGAAGAGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T3858Dichelobacter nodosus VCS1703A

48.193

100

0.482

T3856Dichelobacter nodosus VCS1703A

48.193

100

0.482

T652Leptospira interrogans serovar Lai str. 56601

46.053

91.566

0.422

T4922Actinobacillus pleuropneumoniae serovar 3 str. JL03

44.444

86.747

0.386

T1070Haemophilus influenzae Rd KW20

43.056

86.747

0.373

T439Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

39.189

89.157

0.349

T4914Actinobacillus pleuropneumoniae serovar 3 str. JL03

39.437

85.542

0.337

T10054Bosea sp. PAMC 26642 strain PAMC26642

38.356

87.952

0.337

T10129Haemophilus influenzae strain 69P2H1 N69P2H1_45_2

41.935

74.699

0.313

T1066Haemophilus influenzae Rd KW20

41.935

74.699

0.313
Showing 1 to 10 of 10 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT652Leptospira interrogans serovar Lai str. 56601

45.333

100

0.453

AT3858Dichelobacter nodosus VCS1703A

38.667

100

0.387

AT3856Dichelobacter nodosus VCS1703A

38.667

100

0.387

AT10054Bosea sp. PAMC 26642 strain PAMC26642

32.895

100

0.333

AT6111uncultured bacterium

34.848

88

0.307

AT10197Klebsiella pneumoniae

34.848

88

0.307
Showing 1 to 6 of 6 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Stefan Kopfmann et al. (2016) Type II Toxin-Antitoxin Systems in the Unicellular Cyanobacterium Synechocystis sp. PCC 6803. Toxins 8(7):228. [PubMed:27455323] experimental


experimental experimental literature