Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 308578..309227 | Replicon | chromosome |
| Accession | NZ_CP014301 | ||
| Organism | Bosea sp. PAMC 26642 strain PAMC26642 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A126NQJ4 |
| Locus tag | AXW83_RS01405 | Protein ID | WP_066609966.1 |
| Coordinates | 308829..309227 (+) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A126P2L3 |
| Locus tag | AXW83_RS01400 | Protein ID | WP_066619609.1 |
| Coordinates | 308578..308829 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AXW83_RS01380 (AXW83_01380) | 305115..306056 | + | 942 | WP_066609963.1 | ABC transporter permease | - |
| AXW83_RS01385 (AXW83_01385) | 306053..306949 | + | 897 | WP_066609964.1 | ABC transporter permease | - |
| AXW83_RS01390 (AXW83_01390) | 307087..307386 | - | 300 | WP_066609965.1 | hypothetical protein | - |
| AXW83_RS01395 (AXW83_01395) | 307575..308510 | + | 936 | WP_066619607.1 | N-carbamoyl-D-amino-acid hydrolase | - |
| AXW83_RS01400 (AXW83_01400) | 308578..308829 | + | 252 | WP_066619609.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| AXW83_RS01405 (AXW83_01405) | 308829..309227 | + | 399 | WP_066609966.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| AXW83_RS01410 (AXW83_01410) | 309285..310448 | + | 1164 | WP_066609968.1 | amidohydrolase/deacetylase family metallohydrolase | - |
| AXW83_RS01415 (AXW83_01415) | 310568..311035 | + | 468 | WP_082766883.1 | RidA family protein | - |
| AXW83_RS01420 (AXW83_01420) | 310944..312095 | + | 1152 | WP_082766884.1 | alanine racemase | - |
| AXW83_RS01425 (AXW83_01425) | 312196..312786 | - | 591 | WP_066609971.1 | hypothetical protein | - |
| AXW83_RS01430 (AXW83_01430) | 312868..313596 | - | 729 | WP_066609972.1 | DUF1028 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14793.04 Da Isoelectric Point: 8.2761
>T10054 WP_066609966.1 NZ_CP014301:308829-309227 [Bosea sp. PAMC 26642]
MLAYMLDTNICIYLIKDKLPALRQHFKDASGRVCVSSVTLGELSYGAEKSDRRAQNFEALERFIDRMLVLPFDVQAAGHY
GELRAVLARAGTPCGPLDTQIGAHARSQGLIVVTNNRREFDRMPGLRVENWV
MLAYMLDTNICIYLIKDKLPALRQHFKDASGRVCVSSVTLGELSYGAEKSDRRAQNFEALERFIDRMLVLPFDVQAAGHY
GELRAVLARAGTPCGPLDTQIGAHARSQGLIVVTNNRREFDRMPGLRVENWV
Download Length: 399 bp
>T10054 NZ_CP014301:308829-309227 [Bosea sp. PAMC 26642]
ATGCTGGCCTATATGCTCGACACGAATATTTGCATCTACCTGATCAAGGACAAGCTGCCAGCCCTCCGGCAGCATTTCAA
GGATGCAAGCGGTCGAGTATGCGTTTCCAGCGTAACTCTGGGAGAGCTGAGCTATGGAGCTGAGAAGTCTGATCGCCGCG
CGCAGAACTTCGAAGCCCTGGAACGCTTCATCGACAGGATGCTCGTCCTACCATTCGATGTTCAGGCTGCCGGTCACTAC
GGCGAGTTGCGCGCGGTCTTGGCGCGCGCGGGTACACCTTGCGGGCCGCTCGACACCCAGATCGGCGCCCATGCCCGCAG
CCAAGGCCTGATCGTCGTCACCAATAATCGCCGCGAATTTGACCGCATGCCCGGCCTGCGCGTCGAGAATTGGGTCTGA
ATGCTGGCCTATATGCTCGACACGAATATTTGCATCTACCTGATCAAGGACAAGCTGCCAGCCCTCCGGCAGCATTTCAA
GGATGCAAGCGGTCGAGTATGCGTTTCCAGCGTAACTCTGGGAGAGCTGAGCTATGGAGCTGAGAAGTCTGATCGCCGCG
CGCAGAACTTCGAAGCCCTGGAACGCTTCATCGACAGGATGCTCGTCCTACCATTCGATGTTCAGGCTGCCGGTCACTAC
GGCGAGTTGCGCGCGGTCTTGGCGCGCGCGGGTACACCTTGCGGGCCGCTCGACACCCAGATCGGCGCCCATGCCCGCAG
CCAAGGCCTGATCGTCGTCACCAATAATCGCCGCGAATTTGACCGCATGCCCGGCCTGCGCGTCGAGAATTGGGTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9338.62 Da Isoelectric Point: 4.6151
>AT10054 WP_066619609.1 NZ_CP014301:308578-308829 [Bosea sp. PAMC 26642]
MPAKARATTKLFVTNRTQAVRLPKELAFPPEVTEVEIIRQGSGVLIVPKGKGWDDFFDNGPFASEDFMVTRDQPLAAEER
EEF
MPAKARATTKLFVTNRTQAVRLPKELAFPPEVTEVEIIRQGSGVLIVPKGKGWDDFFDNGPFASEDFMVTRDQPLAAEER
EEF
Download Length: 252 bp
>AT10054 NZ_CP014301:308578-308829 [Bosea sp. PAMC 26642]
ATGCCGGCCAAGGCCCGAGCGACGACGAAGCTCTTCGTGACCAACCGCACTCAGGCCGTGCGCCTGCCGAAAGAACTTGC
CTTCCCGCCGGAGGTGACCGAGGTCGAGATCATCAGGCAGGGCTCGGGGGTGCTGATCGTGCCGAAAGGCAAGGGATGGG
ACGACTTCTTCGACAATGGCCCCTTTGCCAGTGAGGATTTCATGGTCACGAGGGACCAGCCACTGGCGGCAGAGGAACGG
GAAGAGTTCTGA
ATGCCGGCCAAGGCCCGAGCGACGACGAAGCTCTTCGTGACCAACCGCACTCAGGCCGTGCGCCTGCCGAAAGAACTTGC
CTTCCCGCCGGAGGTGACCGAGGTCGAGATCATCAGGCAGGGCTCGGGGGTGCTGATCGTGCCGAAAGGCAAGGGATGGG
ACGACTTCTTCGACAATGGCCCCTTTGCCAGTGAGGATTTCATGGTCACGAGGGACCAGCCACTGGCGGCAGAGGAACGG
GAAGAGTTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT439 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
57.333 |
100 |
0.573 |
| AT652 | Leptospira interrogans serovar Lai str. 56601 |
42.308 |
100 |
0.434 |
| AT3858 | Dichelobacter nodosus VCS1703A |
39.474 |
100 |
0.395 |
| AT3856 | Dichelobacter nodosus VCS1703A |
39.474 |
100 |
0.395 |
| AT4922 | Actinobacillus pleuropneumoniae serovar 3 str. JL03 |
39.189 |
97.368 |
0.382 |
| AT10033 | Thermus thermophilus HB27 |
33.571 |
100 |
0.356 |
| AT10197 | Klebsiella pneumoniae |
33.766 |
100 |
0.342 |
| AT1070 | Haemophilus influenzae Rd KW20 |
41.935 |
80.519 |
0.338 |
| AT962 | Synechocystis sp. PCC 6803 |
32.895 |
100 |
0.333 |
| AT6112 | uncultured bacterium |
31.507 |
96.053 |
0.303 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A126NQJ4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A126P2L3 |
References
(1) Hyerin Jeon et al. (2021) Identification and characterization of VapBC toxin-antitoxin system in Bosea sp. PAMC 26642 isolated from Arctic lichens. RNA (New York, N.Y.) 27(11):1374-1389. [PubMed:34429367]