Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 308578..309227 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name vapC Uniprot ID A0A126NQJ4
Locus tag AXW83_RS01405 Protein ID WP_066609966.1
Coordinates 308829..309227 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A126P2L3
Locus tag AXW83_RS01400 Protein ID WP_066619609.1
Coordinates 308578..308829 (+) Length 84 a.a.

Genomic Context

AXW83_RS01380AXW83_RS01385AXW83_RS01395AXW83_RS01400AXW83_RS01405AXW83_RS01410AXW83_RS01415AXW83_RS01420AXW83_RS01390AXW83_RS01425AXW83_RS01430
Location: 305115..306056 (942 bp)
Type: Others
Protein ID: WP_066609963.1
Location: 306053..306949 (897 bp)
Type: Others
Protein ID: WP_066609964.1
Location: 307575..308510 (936 bp)
Type: Others
Protein ID: WP_066619607.1
Location: 308578..308829 (252 bp)
Type: Antitoxin
Protein ID: WP_066619609.1
Location: 308829..309227 (399 bp)
Type: Toxin
Protein ID: WP_066609966.1
Location: 309285..310448 (1164 bp)
Type: Others
Protein ID: WP_066609968.1
Location: 310568..311035 (468 bp)
Type: Others
Protein ID: WP_082766883.1
Location: 310944..312095 (1152 bp)
Type: Others
Protein ID: WP_082766884.1
Location: 307087..307386 (300 bp)
Type: Others
Protein ID: WP_066609965.1
Location: 312196..312786 (591 bp)
Type: Others
Protein ID: WP_066609971.1
Location: 312868..313596 (729 bp)
Type: Others
Protein ID: WP_066609972.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AXW83_RS01380 (AXW83_01380)305115..306056+942WP_066609963.1ABC transporter permease-
AXW83_RS01385 (AXW83_01385)306053..306949+897WP_066609964.1ABC transporter permease-
AXW83_RS01390 (AXW83_01390)307087..307386-300WP_066609965.1hypothetical protein-
AXW83_RS01395 (AXW83_01395)307575..308510+936WP_066619607.1N-carbamoyl-D-amino-acid hydrolase-
AXW83_RS01400 (AXW83_01400)308578..308829+252WP_066619609.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
AXW83_RS01405 (AXW83_01405)308829..309227+399WP_066609966.1type II toxin-antitoxin system VapC family toxinToxin
AXW83_RS01410 (AXW83_01410)309285..310448+1164WP_066609968.1amidohydrolase/deacetylase family metallohydrolase-
AXW83_RS01415 (AXW83_01415)310568..311035+468WP_082766883.1RidA family protein-
AXW83_RS01420 (AXW83_01420)310944..312095+1152WP_082766884.1alanine racemase-
AXW83_RS01425 (AXW83_01425)312196..312786-591WP_066609971.1hypothetical protein-
AXW83_RS01430 (AXW83_01430)312868..313596-729WP_066609972.1DUF1028 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(12-60)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14793.04 Da        Isoelectric Point: 8.2761

>T10054 WP_066609966.1 NZ_CP014301:308829-309227 [Bosea sp. PAMC 26642]
MLAYMLDTNICIYLIKDKLPALRQHFKDASGRVCVSSVTLGELSYGAEKSDRRAQNFEALERFIDRMLVLPFDVQAAGHY
GELRAVLARAGTPCGPLDTQIGAHARSQGLIVVTNNRREFDRMPGLRVENWV

Download         Length: 399 bp

>T10054 NZ_CP014301:308829-309227 [Bosea sp. PAMC 26642]
ATGCTGGCCTATATGCTCGACACGAATATTTGCATCTACCTGATCAAGGACAAGCTGCCAGCCCTCCGGCAGCATTTCAA
GGATGCAAGCGGTCGAGTATGCGTTTCCAGCGTAACTCTGGGAGAGCTGAGCTATGGAGCTGAGAAGTCTGATCGCCGCG
CGCAGAACTTCGAAGCCCTGGAACGCTTCATCGACAGGATGCTCGTCCTACCATTCGATGTTCAGGCTGCCGGTCACTAC
GGCGAGTTGCGCGCGGTCTTGGCGCGCGCGGGTACACCTTGCGGGCCGCTCGACACCCAGATCGGCGCCCATGCCCGCAG
CCAAGGCCTGATCGTCGTCACCAATAATCGCCGCGAATTTGACCGCATGCCCGGCCTGCGCGTCGAGAATTGGGTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9338.62 Da        Isoelectric Point: 4.6151

>AT10054 WP_066619609.1 NZ_CP014301:308578-308829 [Bosea sp. PAMC 26642]
MPAKARATTKLFVTNRTQAVRLPKELAFPPEVTEVEIIRQGSGVLIVPKGKGWDDFFDNGPFASEDFMVTRDQPLAAEER
EEF

Download         Length: 252 bp

>AT10054 NZ_CP014301:308578-308829 [Bosea sp. PAMC 26642]
ATGCCGGCCAAGGCCCGAGCGACGACGAAGCTCTTCGTGACCAACCGCACTCAGGCCGTGCGCCTGCCGAAAGAACTTGC
CTTCCCGCCGGAGGTGACCGAGGTCGAGATCATCAGGCAGGGCTCGGGGGTGCTGATCGTGCCGAAAGGCAAGGGATGGG
ACGACTTCTTCGACAATGGCCCCTTTGCCAGTGAGGATTTCATGGTCACGAGGGACCAGCCACTGGCGGCAGAGGAACGG
GAAGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T439Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

54.962

99.242

0.545

T4922Actinobacillus pleuropneumoniae serovar 3 str. JL03

48.485

100

0.485

T1070Haemophilus influenzae Rd KW20

46.97

100

0.47

T3858Dichelobacter nodosus VCS1703A

44.961

97.727

0.439

T3856Dichelobacter nodosus VCS1703A

44.961

97.727

0.439

T10197Klebsiella pneumoniae

39.85

100

0.402

T652Leptospira interrogans serovar Lai str. 56601

41.085

97.727

0.402

T6111uncultured bacterium

39.394

100

0.394

T6112uncultured bacterium

38.168

99.242

0.379

T877Sinorhizobium meliloti 1021

36.842

100

0.371
Showing 1 to 10 of 17 rows
1025
 rows per page

Multiple sequence alignment    


Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT439Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

57.333

100

0.573

AT652Leptospira interrogans serovar Lai str. 56601

42.308

100

0.434

AT3858Dichelobacter nodosus VCS1703A

39.474

100

0.395

AT3856Dichelobacter nodosus VCS1703A

39.474

100

0.395

AT4922Actinobacillus pleuropneumoniae serovar 3 str. JL03

39.189

97.368

0.382

AT10033Thermus thermophilus HB27

33.571

100

0.356

AT10197Klebsiella pneumoniae

33.766

100

0.342

AT1070Haemophilus influenzae Rd KW20

41.935

80.519

0.338

AT962Synechocystis sp. PCC 6803

32.895

100

0.333

AT6112uncultured bacterium

31.507

96.053

0.303
Showing 1 to 10 of 10 rows

Multiple sequence alignment    




Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A126NQJ4

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A126P2L3

References

(1) Hyerin Jeon et al. (2021) Identification and characterization of VapBC toxin-antitoxin system in Bosea sp. PAMC 26642 isolated from Arctic lichens. RNA (New York, N.Y.) 27(11):1374-1389. [PubMed:34429367] experimental


experimental experimental literature