Detailed information of TA system TA026219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 474043..474522
• Replicon: chromosome
• Accession: NC_017052
• Organism: Synechocystis sp. PCC 6803 substr. PCC-N

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SYNPCCN_RS02255
• Protein ID: WP_010871640.1
• Coordinates: 474043..474294 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SYNPCCN_RS02260
• Protein ID: WP_010871641.1
• Coordinates: 474295..474522 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNPCCN_RS02235	469091..469636	-	546	WP_010871636.1	alpha/beta hydrolase	-
SYNPCCN_RS02240	469682..471004	+	1323	WP_010871637.1	hypothetical protein	-
SYNPCCN_RS02245	471170..473020	+	1851	WP_010871638.1	ATP-dependent zinc metalloprotease FtsH3	-
SYNPCCN_RS02250	473178..473765	+	588	Protein_444	IS5 family transposase	-
SYNPCCN_RS02255	474043..474294	-	252	WP_010871640.1	type II toxin-antitoxin system VapC family toxin	Toxin
SYNPCCN_RS02260	474295..474522	-	228	WP_010871641.1	virulence factor	Antitoxin
SYNPCCN_RS02265	474601..474882	-	282	WP_020861443.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
SYNPCCN_RS02270	474879..475097	-	219	WP_010871642.1	hypothetical protein	-
SYNPCCN_RS02275	475200..475535	-	336	WP_010871643.1	DUF86 domain-containing protein	-
SYNPCCN_RS02280	475525..475833	-	309	WP_010871644.1	nucleotidyltransferase family protein	-
SYNPCCN_RS02285	475963..477489	-	1527	WP_010871645.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000911 Synechocystis sp. PCC 6803 IS/Tn TA000962, TA020122 473414..473662 0	flank	IS/Tn	-	-	473504..473752	248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9540.13 Da
• Isoelectric Point: 7.9952

>T26219 WP_010871640.1 NC_017052:c474294-474043 [Synechocystis sp. PCC 6803 substr. PCC-N]
MKYLLDTNICIYLIKKKPFKVLAKFQTLEISDIGISSITVAELEYGVSKSQQQSKNRDALMQFLMPLEIVEFNSGSGDRL
WQH

Nucleotide

• Length: 252 bp

>T26219 NC_017052:c474294-474043 [Synechocystis sp. PCC 6803 substr. PCC-N]
ATGAAGTATTTACTAGATACGAATATTTGCATTTATCTCATTAAGAAGAAACCGTTTAAAGTCTTGGCAAAATTTCAAAC
CCTGGAGATATCAGACATTGGTATTTCATCCATTACCGTGGCGGAATTAGAATATGGTGTCAGTAAAAGTCAACAACAAT
CGAAAAATCGTGATGCCTTAATGCAATTCTTGATGCCGCTAGAAATCGTGGAATTTAATTCAGGAAGCGGCGATCGCCTA
TGGCAACATTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8538.69 Da
• Isoelectric Point: 4.2840

>AT26219 WP_010871641.1 NC_017052:c474522-474295 [Synechocystis sp. PCC 6803 substr. PCC-N]
MNTAQISTDGTHQIVILPENFTIAGSEVYIKKIGSTIILIAKNNPWQSLIESLDQFSDDFMKTREQPPLDIREEF

Nucleotide

• Length: 228 bp

>AT26219 NC_017052:c474522-474295 [Synechocystis sp. PCC 6803 substr. PCC-N]
ATGAACACAGCTCAAATTAGCACCGATGGCACCCATCAAATCGTTATTTTACCAGAAAACTTTACGATAGCCGGAAGCGA
AGTTTACATTAAAAAAATTGGAAGTACAATTATTTTGATTGCTAAAAATAACCCTTGGCAATCCTTAATTGAAAGCTTAG
ATCAATTTTCAGATGATTTTATGAAAACTAGGGAACAGCCTCCCTTAGATATACGAGAAGAGTTCTAA