20122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 473953..474432 Replicon chromosome
Accession NC_000911
Organism Synechocystis sp. PCC 6803

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SGL_RS04125 Protein ID WP_010871640.1
Coordinates 473953..474204 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SGL_RS04130 Protein ID WP_010871641.1
Coordinates 474205..474432 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGL_RS04105 (sll1507) 469001..469546 - 546 WP_010871636.1 alpha/beta hydrolase -
SGL_RS04110 (slr1603) 469592..470914 + 1323 WP_010871637.1 hypothetical protein -
SGL_RS04115 (slr1604) 471080..472930 + 1851 WP_010871638.1 ATP-dependent zinc metalloprotease FtsH3 -
SGL_RS04120 473088..473675 + 588 Protein_446 IS5 family transposase -
SGL_RS04125 (ssl2923) 473953..474204 - 252 WP_010871640.1 type II toxin-antitoxin system VapC family toxin Toxin
SGL_RS04130 (ssl2922) 474205..474432 - 228 WP_010871641.1 virulence factor Antitoxin
SGL_RS04135 474511..474792 - 282 WP_020861443.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
SGL_RS04140 (ssl2920) 474789..475007 - 219 WP_010871642.1 hypothetical protein -
SGL_RS04145 (sll1505) 475110..475445 - 336 WP_010871643.1 DUF86 domain-containing protein -
SGL_RS04150 (sll1504) 475435..475743 - 309 WP_010871644.1 nucleotidyltransferase family protein -
SGL_RS04155 (sll1503) 475873..477399 - 1527 WP_010871645.1 RNA-directed DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 473414..473662 248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9540.13 Da        Isoelectric Point: 7.9952

>T20122 WP_010871640.1 NC_000911:c474204-473953 [Synechocystis sp. PCC 6803]
MKYLLDTNICIYLIKKKPFKVLAKFQTLEISDIGISSITVAELEYGVSKSQQQSKNRDALMQFLMPLEIVEFNSGSGDRL
WQH

Download         Length: 252 bp

>T20122 NC_000911:c474204-473953 [Synechocystis sp. PCC 6803]
ATGAAGTATTTACTAGATACGAATATTTGCATTTATCTCATTAAGAAGAAACCGTTTAAAGTCTTGGCAAAATTTCAAAC
CCTGGAGATATCAGACATTGGTATTTCATCCATTACCGTGGCGGAATTAGAATATGGTGTCAGTAAAAGTCAACAACAAT
CGAAAAATCGTGATGCCTTAATGCAATTCTTGATGCCGCTAGAAATCGTGGAATTTAATTCAGGAAGCGGCGATCGCCTA
TGGCAACATTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8538.69 Da        Isoelectric Point: 4.2840

>AT20122 WP_010871641.1 NC_000911:c474432-474205 [Synechocystis sp. PCC 6803]
MNTAQISTDGTHQIVILPENFTIAGSEVYIKKIGSTIILIAKNNPWQSLIESLDQFSDDFMKTREQPPLDIREEF

Download         Length: 228 bp

>AT20122 NC_000911:c474432-474205 [Synechocystis sp. PCC 6803]
ATGAACACAGCTCAAATTAGCACCGATGGCACCCATCAAATCGTTATTTTACCAGAAAACTTTACGATAGCCGGAAGCGA
AGTTTACATTAAAAAAATTGGAAGTACAATTATTTTGATTGCTAAAAATAACCCTTGGCAATCCTTAATTGAAAGCTTAG
ATCAATTTTCAGATGATTTTATGAAAACTAGGGAACAGCCTCCCTTAGATATACGAGAAGAGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References