240914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 473953..474432 Replicon chromosome
Accession NZ_CP094998
Organism Synechocystis sp. PCC 6803 substr. GT-T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MT986_RS02280 Protein ID WP_010871640.1
Coordinates 473953..474204 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MT986_RS02285 Protein ID WP_010871641.1
Coordinates 474205..474432 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT986_RS02260 (MT986_02260) 469001..469531 - 531 WP_041425771.1 alpha/beta hydrolase -
MT986_RS02265 (MT986_02265) 469592..470914 + 1323 WP_010871637.1 hypothetical protein -
MT986_RS02270 (MT986_02270) 471080..472930 + 1851 WP_010871638.1 ATP-dependent zinc metalloprotease FtsH3 -
MT986_RS02275 (MT986_02275) 473139..473675 + 537 Protein_449 IS5 family transposase -
MT986_RS02280 (MT986_02280) 473953..474204 - 252 WP_010871640.1 type II toxin-antitoxin system VapC family toxin Toxin
MT986_RS02285 (MT986_02285) 474205..474432 - 228 WP_010871641.1 virulence factor Antitoxin
MT986_RS02290 (MT986_02290) 474511..474792 - 282 WP_020861443.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
MT986_RS02295 (MT986_02295) 474789..475007 - 219 WP_010871642.1 hypothetical protein -
MT986_RS02300 (MT986_02300) 475110..475445 - 336 WP_010871643.1 DUF86 domain-containing protein -
MT986_RS02305 (MT986_02305) 475435..475743 - 309 WP_010871644.1 nucleotidyltransferase family protein -
MT986_RS02310 (MT986_02310) 475873..477399 - 1527 WP_010871645.1 reverse transcriptase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 473414..473662 248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9540.13 Da        Isoelectric Point: 7.9952

>T240914 WP_010871640.1 NZ_CP094998:c474204-473953 [Synechocystis sp. PCC 6803]
MKYLLDTNICIYLIKKKPFKVLAKFQTLEISDIGISSITVAELEYGVSKSQQQSKNRDALMQFLMPLEIVEFNSGSGDRL
WQH

Download         Length: 252 bp

>T240914 NZ_LT855380:584791-585141 [Pseudomonas viridiflava]
ATGAATACGTTTGCACTGCGCTTTACCGATGTTGCCCAGCAAAGCCTTGAGGATCAGGTTGAACACCTGGCTGTCCATCA
GGGATTCTCATCAGCTGCTCAACGCATAGATACCCTTATCGATGCCATCCAAGACAAGCTCCTGTCTACCCCGTTGGGTT
ACCCGGTCAGTCATCAATTGAGTGAGCTGGGTGTACTGCACTATCGTGAGCTGAACACTGACGGATACCGGATCTTTTAC
GAGGTGAGGGACGCAGGCGATATAAATGTCATCGTCGTGGCGCTCGTGTTAGGTAGCAAGCAAAGTGTTGAACAGGCCCT
CATCCGCTACTGCCTGCTTCAGGCTATATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8538.69 Da        Isoelectric Point: 4.2840

>AT240914 WP_010871641.1 NZ_CP094998:c474432-474205 [Synechocystis sp. PCC 6803]
MNTAQISTDGTHQIVILPENFTIAGSEVYIKKIGSTIILIAKNNPWQSLIESLDQFSDDFMKTREQPPLDIREEF

Download         Length: 228 bp

>AT240914 NZ_LT855380:584530-584778 [Pseudomonas viridiflava]
ATGCGAGTTGAAACAATCAGTTTTCTGAAACGCAACGCAGCCGACCTGCCTCTCGATGAGCCCTTGGTCGTCACGCAAAA
TGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCTGATCGTAAGCGCCGCGATGAGTCAATCGCCTTGGTGAAGCTCCTGG
CAATCAGCTCCCGCGAGTACTCCCAAGGCAAGCACTGTTCCACTGACGAACTCAAAGCCCGATTGAGCAGGAGGTTTACC
CAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References