NZ_CP013304309816..427298

MGE detailed information

MGE type: Integron        MGE length: 117483 bp
Accession: NZ_CP013304        Location: 309816..427298         Organism: Vibrio cholerae strain CRC711       Replicon: chromosome


Gene structure


The 5 kb flanking regions of this MGE are displayed.

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ82_RS15520 () 305266..305937 + 672 WP_000132861.1 hypothetical protein -
ASZ82_RS20345 () 306062..306289 + 228 WP_001911595.1 hypothetical protein -
ASZ82_RS15530 () 306558..308486 + 1929 WP_001121779.1 threonine--tRNA ligase -
ASZ82_RS15535 () 308490..309041 + 552 WP_001894072.1 translation initiation factor IF-3 -
ASZ82_RS15540 () 309145..309339 + 195 WP_001885060.1 50S ribosomal protein L35 -
ASZ82_RS15545 () 309381..309734 + 354 WP_001138366.1 50S ribosomal protein L20 -
ASZ82_RS15550 () 309816..310778 - 963 WP_000841995.1 IS91 family transposase ISAzo26 Transposase
ASZ82_RS15560 () 311258..311425 + 168 WP_001883086.1 DUF3265 domain-containing protein -
ASZ82_RS15565 () 311454..311780 + 327 WP_001921550.1 hypothetical protein -
ASZ82_RS20500 () 311824..311913 + 90 WP_072615218.1 DUF3265 domain-containing protein -
ASZ82_RS15585 () 312577..312759 + 183 WP_000923182.1 DUF645 family protein -
ASZ82_RS15590 () 313015..313266 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ82_RS15595 () 313239..313388 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ82_RS15600 () 313419..313850 + 432 WP_000795498.1 hypothetical protein -
ASZ82_RS15605 () 314001..314630 + 630 WP_001009012.1 Chloramphenicol acetyltransferase VF
ASZ82_RS15610 () 314786..315538 + 753 WP_000116045.1 putative oxidoreductase YgfF VF
ASZ82_RS15615 () 315841..316020 + 180 WP_053052193.1 DUF645 family protein -
ASZ82_RS15620 () 316375..316557 + 183 WP_033837530.1 DUF645 family protein -
ASZ82_RS15625 () 316800..317213 + 414 WP_071908307.1 VOC family protein -
ASZ82_RS15630 () 317315..317980 + 666 WP_053035036.1 HNH endonuclease -
ASZ82_RS15635 () 317998..318087 + 90 WP_080261010.1 DUF3265 domain-containing protein -
ASZ82_RS15645 () 319353..319841 + 489 WP_053035033.1 hypothetical protein -
ASZ82_RS15650 () 319967..320332 + 366 WP_000434800.1 hypothetical protein -
ASZ82_RS15655 () 320966..321505 + 540 WP_053035032.1 phosphoglycerate mutase family protein -
ASZ82_RS15660 () 321640..322065 + 426 WP_000693748.1 hypothetical protein -
ASZ82_RS20410 () 322122..322232 + 111 WP_106746893.1 iron transporter -
ASZ82_RS15665 () 322219..322578 + 360 WP_001071527.1 VOC family protein -
ASZ82_RS20505 () 322720..323153 + 434 Protein_277 GNAT family N-acetyltransferase -
ASZ82_RS15675 () 323290..324216 + 927 WP_000377813.1 hypothetical protein -
ASZ82_RS19975 () 324539..324692 + 154 Protein_279 DUF645 family protein -
ASZ82_RS15685 () 324921..325424 + 504 WP_001158950.1 DinB family protein -
ASZ82_RS15690 () 325566..326063 - 498 WP_000982256.1 GNAT family N-acetyltransferase Toxin Detail
ASZ82_RS15695 () 326060..326332 - 273 WP_000246254.1 DUF1778 domain-containing protein Antitoxin Detail
ASZ82_RS15700 () 326720..326887 + 168 WP_053035038.1 DUF645 family protein -
ASZ82_RS15705 () 327095..327442 + 348 WP_000933413.1 hypothetical protein -
ASZ82_RS15715 () 328127..328309 + 183 WP_000923340.1 DUF645 family protein -
ASZ82_RS15720 () 328524..329063 + 540 WP_000099372.1 hypothetical protein -
ASZ82_RS15725 () 329186..329701 + 516 WP_000090011.1 hypothetical protein -
ASZ82_RS15730 () 329836..330372 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ82_RS20420 () 330491..330652 + 162 WP_000481782.1 hypothetical protein -
ASZ82_RS15735 () 330841..330951 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ82_RS15745 () 331164..331316 + 153 WP_001884520.1 DUF645 family protein -
ASZ82_RS15750 () 331600..332043 + 444 WP_000803902.1 hypothetical protein -
ASZ82_RS15755 () 332047..332157 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ82_RS15760 () 332187..332465 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin Detail
ASZ82_RS15765 () 332462..332746 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin Detail
ASZ82_RS15775 () 332922..333221 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS15780 () 333218..333460 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin Detail
ASZ82_RS15790 () 333879..333956 + 78 WP_071908337.1 DUF645 family protein -
ASZ82_RS20350 () 333960..333986 + 27 Protein_299 hypothetical protein -
ASZ82_RS20425 () 334572..334715 + 144 WP_001900215.1 hypothetical protein -
ASZ82_RS20010 () 334809..334988 + 180 Protein_301 DUF645 family protein -
ASZ82_RS15815 () 335206..335634 + 429 WP_000620002.1 putative N-acetyltransferase YjaB VF
ASZ82_RS15825 () 336222..336704 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ82_RS15835 () 337512..337781 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin Detail
ASZ82_RS15840 () 337775..338296 + 522 WP_000921692.1 DUF2442 domain-containing protein Antitoxin Detail
ASZ82_RS15845 () 338353..338466 + 114 WP_001894981.1 hypothetical protein -
ASZ82_RS15850 () 338435..339271 + 837 WP_000242986.1 hypothetical protein -
ASZ82_RS15855 () 339436..340074 + 639 WP_000230118.1 HD domain-containing protein -
ASZ82_RS20030 () 340164..340324 + 161 Protein_309 DUF3709 domain-containing protein -
ASZ82_RS15860 () 340345..340566 + 222 WP_012705854.1 DUF3709 domain-containing protein -
ASZ82_RS15870 () 340886..341206 + 321 WP_001909340.1 DUF1778 domain-containing protein Antitoxin Detail
ASZ82_RS15875 () 341203..341736 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin Detail
ASZ82_RS15880 () 341974..342252 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ82_RS15885 () 342653..342877 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ82_RS15895 () 343615..344004 + 390 WP_000491263.1 VOC family protein -
ASZ82_RS15900 () 344137..344652 + 516 WP_000090008.1 hypothetical protein -
ASZ82_RS15905 () 344793..345230 + 438 WP_001202554.1 NUDIX pyrophosphatase -
ASZ82_RS15910 () 345391..345738 + 348 WP_000933409.1 hypothetical protein -
ASZ82_RS15915 () 345879..347444 + 1566 WP_000275416.1 RNA-directed DNA polymerase -
ASZ82_RS15920 () 347580..348140 + 561 WP_000400489.1 hypothetical protein -
ASZ82_RS15925 () 348290..348964 + 675 WP_000073446.1 hypothetical protein -
ASZ82_RS15930 () 349169..349411 + 243 WP_000107461.1 hypothetical protein -
ASZ82_RS15935 () 349663..349941 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ82_RS20430 () 350316..350459 + 144 Protein_324 DUF645 family protein -
ASZ82_RS20435 () 350513..350551 + 39 WP_082798268.1 hypothetical protein -
ASZ82_RS15950 () 350763..351230 + 468 WP_001289288.1 OsmC family protein -
ASZ82_RS15955 () 351358..352020 + 663 WP_000960654.1 hypothetical protein -
ASZ82_RS15960 () 352205..352471 + 267 WP_000589156.1 BrnT family toxin Toxin Detail
ASZ82_RS15965 () 352458..352703 + 246 WP_000643598.1 hypothetical protein Antitoxin Detail
ASZ82_RS15970 () 352799..353593 + 795 WP_001911581.1 hypothetical protein -
ASZ82_RS20440 () 353696..353824 + 129 WP_071908338.1 general secretion pathway protein GspI -
ASZ82_RS15985 () 353885..354067 + 183 WP_000923182.1 DUF645 family protein -
ASZ82_RS15990 () 354283..355287 + 1005 WP_000964920.1 LD-carboxypeptidase -
ASZ82_RS15995 () 355440..355799 + 360 WP_001071541.1 VOC family protein -
ASZ82_RS16000 () 356072..356305 + 234 WP_001890112.1 DUF3709 domain-containing protein -
ASZ82_RS16005 () 356573..357079 + 507 WP_000393074.1 hypothetical protein -
ASZ82_RS16010 () 357236..357622 + 387 WP_000703163.1 VOC family protein -
ASZ82_RS16015 () 357879..358082 + 204 WP_001911580.1 hypothetical protein -
ASZ82_RS16020 () 358277..358528 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ82_RS16025 () 358501..358650 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ82_RS16030 () 358797..359222 + 426 WP_000415750.1 hypothetical protein -
ASZ82_RS16035 () 359428..360051 + 624 WP_000247070.1 DUF1349 domain-containing protein -
ASZ82_RS16040 () 360264..360743 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
ASZ82_RS16045 () 360931..361344 + 414 WP_000049420.1 VOC family protein -
ASZ82_RS16050 () 361495..361773 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin Detail
ASZ82_RS16055 () 361770..362054 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin Detail
ASZ82_RS16065 () 362249..362764 + 516 WP_001201520.1 lipocalin family protein -
ASZ82_RS16070 () 362829..363425 + 597 WP_000255434.1 hypothetical protein -
ASZ82_RS16085 () 363817..363999 + 183 WP_000923182.1 DUF645 family protein -
ASZ82_RS16090 () 364199..364672 + 474 WP_001161076.1 GrpB family protein -
ASZ82_RS16095 () 364687..364779 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ82_RS16100 () 364821..365447 + 627 WP_000365424.1 LysE family translocator -
ASZ82_RS16105 () 365570..366268 + 699 WP_001890502.1 hypothetical protein -
ASZ82_RS16110 () 366278..366388 + 111 WP_079857360.1 DUF3265 domain-containing protein -
ASZ82_RS16120 () 366966..367145 + 180 WP_001883058.1 DUF645 family protein -
ASZ82_RS16125 () 367359..367754 + 396 WP_000870857.1 DUF3465 domain-containing protein -
ASZ82_RS16130 () 367882..368181 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS16135 () 368178..368420 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin Detail
ASZ82_RS16140 () 368649..369227 + 579 WP_000110120.1 hypothetical protein -
ASZ82_RS16145 () 369249..369341 + 93 WP_014164112.1 DUF3265 domain-containing protein -
ASZ82_RS16155 () 369765..370448 + 684 WP_000877436.1 hypothetical protein -
ASZ82_RS16160 () 370662..370928 + 267 WP_000937852.1 hypothetical protein -
ASZ82_RS16165 () 371083..371682 + 600 WP_000429495.1 hypothetical protein -
ASZ82_RS16170 () 371963..372898 + 936 WP_000051985.1 restriction endonuclease -
ASZ82_RS16175 () 372864..373004 + 141 WP_001883049.1 DUF3265 domain-containing protein -
ASZ82_RS16180 () 373014..373409 + 396 WP_000046952.1 hypothetical protein -
ASZ82_RS16185 () 373712..373893 + 182 Protein_367 DUF645 family protein -
ASZ82_RS16190 () 374070..374465 + 396 WP_000046953.1 hypothetical protein -
ASZ82_RS16195 () 374609..375145 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ82_RS16200 () 375442..375621 + 180 WP_001883039.1 DUF645 family protein -
ASZ82_RS16205 () 375817..376242 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ82_RS16210 () 376391..376738 + 348 WP_000933409.1 hypothetical protein -
ASZ82_RS20100 () 376885..377178 + 294 WP_125460920.1 hypothetical protein -
ASZ82_RS20445 () 377534..377629 + 96 WP_001907607.1 DUF645 family protein -
ASZ82_RS16230 () 377823..378140 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS16235 () 378159..378401 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin Detail
ASZ82_RS16240 () 378643..379152 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ82_RS16245 () 379209..379862 + 654 WP_000226874.1 hypothetical protein -
ASZ82_RS16250 () 380172..380390 + 219 WP_001917086.1 DUF3709 domain-containing protein -
ASZ82_RS16260 () 380793..381026 + 234 WP_032482776.1 DUF3709 domain-containing protein -
ASZ82_RS16265 () 381451..381631 + 181 Protein_381 DUF645 family protein -
ASZ82_RS16270 () 381898..382185 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS16275 () 382196..382513 + 318 WP_001232701.1 HigA family addiction module antidote protein Antitoxin Detail
ASZ82_RS20450 () 382510..382620 + 111 WP_134814058.1 DUF3265 domain-containing protein -
ASZ82_RS20455 () 382797..382922 + 126 WP_001944767.1 DUF645 family protein -
ASZ82_RS20460 () 382938..382976 + 39 WP_106019119.1 hypothetical protein -
ASZ82_RS16295 () 383200..383940 + 741 WP_000469836.1 PhzF family phenazine biosynthesis protein -
ASZ82_RS16300 () 384145..384975 + 831 WP_000056616.1 abortive infection family protein -
ASZ82_RS16305 () 385032..385514 + 483 WP_001895003.1 hypothetical protein -
ASZ82_RS16315 () 385961..386836 + 876 WP_000259044.1 hypothetical protein -
ASZ82_RS16320 () 386966..387421 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ82_RS20510 () 387478..387573 + 96 WP_080368267.1 acetyltransferase -
ASZ82_RS16325 () 387605..388018 + 414 WP_000049417.1 VOC family protein -
ASZ82_RS16335 () 388169..388603 + 435 WP_000453957.1 GNAT family N-acetyltransferase -
ASZ82_RS16350 () 389389..389559 + 171 WP_000483445.1 DUF645 family protein -
ASZ82_RS16355 () 389787..390407 + 621 WP_000466864.1 YrdB family protein -
ASZ82_RS16360 () 390555..391070 + 516 WP_001201528.1 lipocalin family protein -
ASZ82_RS16365 () 391206..391496 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS16370 () 391486..391734 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin Detail
ASZ82_RS16380 () 392305..392958 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
ASZ82_RS16385 () 393230..393655 + 426 WP_000415748.1 hypothetical protein -
ASZ82_RS16390 () 393863..394258 + 396 WP_000649527.1 DUF3465 domain-containing protein -
ASZ82_RS16395 () 394409..394939 + 531 WP_000415563.1 hypothetical protein -
ASZ82_RS16400 () 395077..395577 + 501 WP_000789723.1 hypothetical protein -
ASZ82_RS16405 () 395733..396131 + 399 WP_001882293.1 hypothetical protein -
ASZ82_RS16410 () 396231..396695 - 465 WP_000140244.1 hypothetical protein -
ASZ82_RS16415 () 397078..398063 - 986 Protein_407 Sulfate-binding protein VF
ASZ82_RS16420 () 398314..398892 + 579 WP_001020575.1 DJ-1/PfpI family protein -
ASZ82_RS16435 () 399196..399366 + 171 WP_001882300.1 DUF645 family protein -
ASZ82_RS16440 () 399689..400303 + 615 WP_000789577.1 hypothetical protein -
ASZ82_RS16445 () 400450..401307 + 858 WP_001279526.1 DUF2806 domain-containing protein -
ASZ82_RS16450 () 401463..402014 + 552 WP_000821930.1 hypothetical protein -
ASZ82_RS20360 () 402301..402504 + 204 WP_001911745.1 hypothetical protein -
ASZ82_RS20160 () 402785..402958 + 174 WP_001882305.1 DUF3709 domain-containing protein -
ASZ82_RS16465 () 403318..403587 + 270 WP_001198131.1 hypothetical protein -
ASZ82_RS20515 () 403905..404076 + 172 Protein_416 DUF645 family protein -
ASZ82_RS16480 () 404285..404671 + 387 WP_000703163.1 VOC family protein -
ASZ82_RS16485 () 404873..405115 + 243 WP_000107461.1 hypothetical protein -
ASZ82_RS16490 () 405286..405663 + 378 WP_000411109.1 hypothetical protein -
ASZ82_RS20480 () 405720..405834 + 115 Protein_420 acetyltransferase -
ASZ82_RS16495 () 405783..406064 + 282 WP_001894453.1 DUF1289 domain-containing protein -
ASZ82_RS16510 () 406230..406343 + 114 WP_001889158.1 hypothetical protein -
ASZ82_RS16515 () 406292..406519 + 228 WP_001894457.1 DUF1289 domain-containing protein -
ASZ82_RS16525 () 406860..407192 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS16530 () 407179..407493 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin Detail
ASZ82_RS16535 () 407630..408064 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ82_RS20270 () 408232..408387 + 156 WP_000751734.1 hypothetical protein -
ASZ82_RS16545 () 408512..409492 - 981 WP_000019370.1 IS5 family transposase ISVch5 Transposase
ASZ82_RS16550 () 409560..409866 + 307 Protein_429 Streptogramin A acetyltransferase VF
ASZ82_RS16555 () 410003..410695 + 693 WP_001047169.1 GNAT family N-acetyltransferase Antitoxin Detail
ASZ82_RS16560 () 410695..411096 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin Detail
ASZ82_RS20175 () 411066..411209 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ82_RS16570 () 411284..411697 + 414 WP_000049417.1 VOC family protein -
ASZ82_RS16575 () 411911..412162 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin Detail
ASZ82_RS16580 () 412152..412439 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS16585 () 412567..413022 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ82_RS16595 () 413344..413496 + 153 WP_001884520.1 DUF645 family protein -
ASZ82_RS16600 () 413698..414195 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin Detail
ASZ82_RS16605 () 414192..414464 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin Detail
ASZ82_RS16610 () 414695..415363 + 669 WP_000043871.1 hypothetical protein -
ASZ82_RS16615 () 415515..415802 + 288 WP_000426470.1 hypothetical protein -
ASZ82_RS16620 () 415943..416314 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ82_RS16625 () 416381..416806 + 426 WP_001882332.1 DUF1778 domain-containing protein Antitoxin Detail
ASZ82_RS16630 () 416803..417336 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin Detail
ASZ82_RS16635 () 417538..417795 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin Detail
ASZ82_RS16640 () 417783..418085 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
ASZ82_RS16645 () 418319..419236 + 918 WP_000186333.1 alpha/beta hydrolase -
ASZ82_RS16655 () 419393..419782 + 390 WP_001081302.1 hypothetical protein -
ASZ82_RS16660 () 419918..420127 + 210 Protein_449 GNAT family N-acetyltransferase -
ASZ82_RS16665 () 420246..420683 + 438 WP_000503169.1 IS200-IS605 family transposase IS1004 Transposase
ASZ82_RS16670 () 420747..420965 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
ASZ82_RS16680 () 421140..422012 + 873 WP_000254716.1 DUF3800 domain-containing protein -
ASZ82_RS16685 () 422162..422761 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ82_RS20195 () 422818..422922 + 105 WP_099607150.1 acetyltransferase Antitoxin Detail
ASZ82_RS16690 () 422953..423222 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin Detail
ASZ82_RS16695 () 423216..423737 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin Detail
ASZ82_RS20200 () 424036..424161 + 126 WP_001905700.1 DUF645 family protein -
ASZ82_RS16710 () 424412..424807 + 396 WP_001000867.1 hypothetical protein -
ASZ82_RS16715 () 424946..425224 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin Detail
ASZ82_RS16720 () 425221..425505 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin Detail
ASZ82_RS16725 () 425699..426214 + 516 WP_000343779.1 dTDP-fucosamine acetyltransferase VF
ASZ82_RS16730 () 426398..426811 + 414 WP_000049420.1 VOC family protein -
ASZ82_RS16745 () 427366..428543 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -
ASZ82_RS16750 () 428962..431739 + 2778 WP_000509635.1 alkaline phosphatase family protein -

Similar MGE(s)


Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.

Detail Organism MGE type Related TA Genome accession Coordinates Mash
distance