Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 410003..411096 Replicon chromosome
Accession NZ_CP013304
Organism Vibrio cholerae strain CRC711

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ82_RS16560 Protein ID WP_000351248.1
Coordinates 410695..411096 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ82_RS16555 Protein ID WP_001047169.1
Coordinates 410003..410695 (+) Length 231 a.a.

Genomic Context

ASZ82_RS16490ASZ82_RS20480ASZ82_RS16495ASZ82_RS16510ASZ82_RS16515ASZ82_RS16525ASZ82_RS16530ASZ82_RS16535ASZ82_RS20270ASZ82_RS16550ASZ82_RS16555ASZ82_RS16560ASZ82_RS20175ASZ82_RS16570ASZ82_RS16575ASZ82_RS16580ASZ82_RS16585ASZ82_RS16595ASZ82_RS16610ASZ82_RS16615ASZ82_RS16545ASZ82_RS16600ASZ82_RS16605
Location: 405286..405663 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 405720..405834 (115 bp)
Type: Others
Protein ID: Protein_420
Location: 405783..406064 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 406230..406343 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 406292..406519 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 406860..407192 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 407179..407493 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 407630..408064 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 408232..408387 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 409560..409866 (307 bp)
Type: Others
Protein ID: Protein_429
Location: 410003..410695 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 410695..411096 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 411066..411209 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 411284..411697 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 411911..412162 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 412152..412439 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 412567..413022 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 413344..413496 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 414695..415363 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 415515..415802 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 408512..409492 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 413698..414195 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 414192..414464 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ82_RS16490405286..405663+378WP_000411109.1hypothetical protein-
ASZ82_RS20480405720..405834+115Protein_420acetyltransferase-
ASZ82_RS16495405783..406064+282WP_001894453.1DUF1289 domain-containing protein-
ASZ82_RS16510406230..406343+114WP_001889158.1hypothetical protein-
ASZ82_RS16515406292..406519+228WP_001894457.1DUF1289 domain-containing protein-
ASZ82_RS16525406860..407192+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ82_RS16530407179..407493+315WP_000071008.1DNA-binding transcriptional regulator-
ASZ82_RS16535407630..408064+435WP_000256036.1GNAT family N-acetyltransferase-
ASZ82_RS20270408232..408387+156WP_000751734.1hypothetical protein-
ASZ82_RS16545408512..409492-981WP_000019370.1IS5-like element ISVch5 family transposase-
ASZ82_RS16550409560..409866+307Protein_429CatB-related O-acetyltransferase-
ASZ82_RS16555410003..410695+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
ASZ82_RS16560410695..411096+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
ASZ82_RS20175411066..411209+144WP_071908341.1DUF3265 domain-containing protein-
ASZ82_RS16570411284..411697+414WP_000049417.1VOC family protein-
ASZ82_RS16575411911..412162+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ82_RS16580412152..412439+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ82_RS16585412567..413022+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ82_RS16595413344..413496+153WP_001884520.1DUF645 family protein-
ASZ82_RS16600413698..414195-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ82_RS16605414192..414464-273WP_000246253.1DUF1778 domain-containing protein-
ASZ82_RS16610414695..415363+669WP_000043871.1hypothetical protein-
ASZ82_RS16615415515..415802+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304736..427674122938
-insideIntegron--309816..427298117482
flankIS/Tn--408512..409492980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58249 WP_000351248.1 NZ_CP013304:410695-411096 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58249 NZ_CP013304:410695-411096 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT58249 WP_001047169.1 NZ_CP013304:410003-410695 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58249 NZ_CP013304:410003-410695 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References