58245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 377823..378401 Replicon chromosome
Accession NZ_CP013304
Organism Vibrio cholerae strain CRC711

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ82_RS16230 Protein ID WP_001180243.1
Coordinates 377823..378140 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ82_RS16235 Protein ID WP_000557292.1
Coordinates 378159..378401 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ82_RS16175 372864..373004 + 141 WP_001883049.1 DUF3265 domain-containing protein -
ASZ82_RS16180 373014..373409 + 396 WP_000046952.1 hypothetical protein -
ASZ82_RS16185 373712..373893 + 182 Protein_367 DUF645 family protein -
ASZ82_RS16190 374070..374465 + 396 WP_000046953.1 hypothetical protein -
ASZ82_RS16195 374609..375145 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ82_RS16200 375442..375621 + 180 WP_001883039.1 DUF645 family protein -
ASZ82_RS16205 375817..376242 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ82_RS16210 376391..376738 + 348 WP_000933409.1 hypothetical protein -
ASZ82_RS20100 376885..377178 + 294 WP_125460920.1 hypothetical protein -
ASZ82_RS20445 377534..377629 + 96 WP_001907607.1 DUF645 family protein -
ASZ82_RS16230 377823..378140 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ82_RS16235 378159..378401 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ82_RS16240 378643..379152 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ82_RS16245 379209..379862 + 654 WP_000226874.1 hypothetical protein -
ASZ82_RS16250 380172..380390 + 219 WP_001917086.1 DUF3709 domain-containing protein -
ASZ82_RS16260 380793..381026 + 234 WP_032482776.1 DUF3709 domain-containing protein -
ASZ82_RS16265 381451..381631 + 181 Protein_381 DUF645 family protein -
ASZ82_RS16270 381898..382185 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ82_RS16275 382196..382513 + 318 WP_001232701.1 HigA family addiction module antidote protein -
ASZ82_RS20450 382510..382620 + 111 WP_134814058.1 DUF3265 domain-containing protein -
ASZ82_RS20455 382797..382922 + 126 WP_001944767.1 DUF645 family protein -
ASZ82_RS20460 382938..382976 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304736..427674 122938
- inside Integron - - 309816..427298 117482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58245 WP_001180243.1 NZ_CP013304:c378140-377823 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58245 NZ_CP013304:c378140-377823 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58245 WP_000557292.1 NZ_CP013304:c378401-378159 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58245 NZ_CP013304:c378401-378159 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References