Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 361495..362054 | Replicon | chromosome |
| Accession | NZ_CP013304 | ||
| Organism | Vibrio cholerae strain CRC711 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9K2M8 |
| Locus tag | ASZ82_RS16050 | Protein ID | WP_000578476.1 |
| Coordinates | 361495..361773 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | ASZ82_RS16055 | Protein ID | WP_000381183.1 |
| Coordinates | 361770..362054 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ82_RS16005 | 356573..357079 | + | 507 | WP_000393074.1 | hypothetical protein | - |
| ASZ82_RS16010 | 357236..357622 | + | 387 | WP_000703163.1 | VOC family protein | - |
| ASZ82_RS16015 | 357879..358082 | + | 204 | WP_001911580.1 | hypothetical protein | - |
| ASZ82_RS16020 | 358277..358528 | + | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| ASZ82_RS16025 | 358501..358650 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| ASZ82_RS16030 | 358797..359222 | + | 426 | WP_000415750.1 | hypothetical protein | - |
| ASZ82_RS16035 | 359428..360051 | + | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
| ASZ82_RS16040 | 360264..360743 | + | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
| ASZ82_RS16045 | 360931..361344 | + | 414 | WP_000049420.1 | VOC family protein | - |
| ASZ82_RS16050 | 361495..361773 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| ASZ82_RS16055 | 361770..362054 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| ASZ82_RS16065 | 362249..362764 | + | 516 | WP_001201520.1 | lipocalin family protein | - |
| ASZ82_RS16070 | 362829..363425 | + | 597 | WP_000255434.1 | hypothetical protein | - |
| ASZ82_RS16085 | 363817..363999 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
| ASZ82_RS16090 | 364199..364672 | + | 474 | WP_001161076.1 | GrpB family protein | - |
| ASZ82_RS16095 | 364687..364779 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| ASZ82_RS16100 | 364821..365447 | + | 627 | WP_000365424.1 | LysE family translocator | - |
| ASZ82_RS16105 | 365570..366268 | + | 699 | WP_001890502.1 | hypothetical protein | - |
| ASZ82_RS16110 | 366278..366388 | + | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 304736..427674 | 122938 | |
| - | inside | Integron | - | - | 309816..427298 | 117482 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T58243 WP_000578476.1 NZ_CP013304:c361773-361495 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T58243 NZ_CP013304:c361773-361495 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT58243 WP_000381183.1 NZ_CP013304:c362054-361770 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT58243 NZ_CP013304:c362054-361770 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9K2M8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |