Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 424946..425505 Replicon chromosome
Accession NZ_CP013304
Organism Vibrio cholerae strain CRC711

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ82_RS16715 Protein ID WP_000578476.1
Coordinates 424946..425224 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ82_RS16720 Protein ID WP_000381183.1
Coordinates 425221..425505 (-) Length 95 a.a.

Genomic Context

ASZ82_RS16665ASZ82_RS16670ASZ82_RS16680ASZ82_RS16685ASZ82_RS20195ASZ82_RS16690ASZ82_RS16695ASZ82_RS20200ASZ82_RS16710ASZ82_RS16725ASZ82_RS16730ASZ82_RS16745ASZ82_RS16715ASZ82_RS16720
Location: 420246..420683 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 420747..420965 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 421140..422012 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 422162..422761 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 422818..422922 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 422953..423222 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 423216..423737 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 424036..424161 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 424412..424807 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 425699..426214 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 426398..426811 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 427366..428543 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 424946..425224 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 425221..425505 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ82_RS16665420246..420683+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ82_RS16670420747..420965+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ82_RS16680421140..422012+873WP_000254716.1DUF3800 domain-containing protein-
ASZ82_RS16685422162..422761+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ82_RS20195422818..422922+105WP_099607150.1acetyltransferase-
ASZ82_RS16690422953..423222+270WP_001114075.1DUF4160 domain-containing protein-
ASZ82_RS16695423216..423737+522WP_000921691.1DUF2442 domain-containing protein-
ASZ82_RS20200424036..424161+126WP_001905700.1DUF645 family protein-
ASZ82_RS16710424412..424807+396WP_001000867.1hypothetical protein-
ASZ82_RS16715424946..425224-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ82_RS16720425221..425505-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ82_RS16725425699..426214+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ82_RS16730426398..426811+414WP_000049420.1VOC family protein-
ASZ82_RS16745427366..428543+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304736..427674122938
-insideIntegron--309816..427298117482
flankIS/Tn--420246..420683437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58256 WP_000578476.1 NZ_CP013304:c425224-424946 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58256 NZ_CP013304:c425224-424946 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58256 WP_000381183.1 NZ_CP013304:c425505-425221 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58256 NZ_CP013304:c425505-425221 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References