Detailed information of TA system TA058252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 416381..417336
• Replicon: chromosome
• Accession: NZ_CP013304
• Organism: Vibrio cholerae strain CRC711

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: ASZ82_RS16630
• Protein ID: WP_000118351.1
• Coordinates: 416803..417336 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASZ82_RS16625
• Protein ID: WP_001882332.1
• Coordinates: 416381..416806 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ82_RS16575	411911..412162	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ASZ82_RS16580	412152..412439	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ82_RS16585	412567..413022	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
ASZ82_RS16595	413344..413496	+	153	WP_001884520.1	DUF645 family protein	-
ASZ82_RS16600	413698..414195	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
ASZ82_RS16605	414192..414464	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
ASZ82_RS16610	414695..415363	+	669	WP_000043871.1	hypothetical protein	-
ASZ82_RS16615	415515..415802	+	288	WP_000426470.1	hypothetical protein	-
ASZ82_RS16620	415943..416314	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
ASZ82_RS16625	416381..416806	+	426	WP_001882332.1	DUF1778 domain-containing protein	Antitoxin
ASZ82_RS16630	416803..417336	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
ASZ82_RS16635	417538..417795	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ASZ82_RS16640	417783..418085	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ82_RS16645	418319..419236	+	918	WP_000186333.1	alpha/beta hydrolase	-
ASZ82_RS16655	419393..419782	+	390	WP_001081302.1	hypothetical protein	-
ASZ82_RS16660	419918..420127	+	210	Protein_449	GNAT family N-acetyltransferase	-
ASZ82_RS16665	420246..420683	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
ASZ82_RS16670	420747..420965	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
ASZ82_RS16680	421140..422012	+	873	WP_000254716.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304736..427674	122938
	-	inside	Integron	-	-	309816..427298	117482
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	420246..420683	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (57-133)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T58252 WP_000118351.1 NZ_CP013304:416803-417336 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T58252 NZ_CP013304:416803-417336 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15714.41 Da
• Isoelectric Point: 7.6659

>AT58252 WP_001882332.1 NZ_CP013304:416381-416806 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 426 bp

>AT58252 NZ_CP013304:416381-416806 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Structures

Toxin

• AlphaFold DB: Q9KM94