Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 416381..417336 Replicon chromosome
Accession NZ_CP013304
Organism Vibrio cholerae strain CRC711

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag ASZ82_RS16630 Protein ID WP_000118351.1
Coordinates 416803..417336 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ82_RS16625 Protein ID WP_001882332.1
Coordinates 416381..416806 (+) Length 142 a.a.

Genomic Context

ASZ82_RS16575ASZ82_RS16580ASZ82_RS16585ASZ82_RS16595ASZ82_RS16610ASZ82_RS16615ASZ82_RS16620ASZ82_RS16625ASZ82_RS16630ASZ82_RS16635ASZ82_RS16640ASZ82_RS16645ASZ82_RS16655ASZ82_RS16660ASZ82_RS16665ASZ82_RS16670ASZ82_RS16680ASZ82_RS16600ASZ82_RS16605
Location: 411911..412162 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 412152..412439 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 412567..413022 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 413344..413496 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 414695..415363 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 415515..415802 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 415943..416314 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 416381..416806 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 416803..417336 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 417538..417795 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 417783..418085 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 418319..419236 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 419393..419782 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 419918..420127 (210 bp)
Type: Others
Protein ID: Protein_449
Location: 420246..420683 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 420747..420965 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 421140..422012 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 413698..414195 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 414192..414464 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ82_RS16575411911..412162+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ82_RS16580412152..412439+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ82_RS16585412567..413022+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ82_RS16595413344..413496+153WP_001884520.1DUF645 family protein-
ASZ82_RS16600413698..414195-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ82_RS16605414192..414464-273WP_000246253.1DUF1778 domain-containing protein-
ASZ82_RS16610414695..415363+669WP_000043871.1hypothetical protein-
ASZ82_RS16615415515..415802+288WP_000426470.1hypothetical protein-
ASZ82_RS16620415943..416314+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ82_RS16625416381..416806+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
ASZ82_RS16630416803..417336+534WP_000118351.1GNAT family N-acetyltransferaseToxin
ASZ82_RS16635417538..417795+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ82_RS16640417783..418085+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ82_RS16645418319..419236+918WP_000186333.1alpha/beta hydrolase-
ASZ82_RS16655419393..419782+390WP_001081302.1hypothetical protein-
ASZ82_RS16660419918..420127+210Protein_449GNAT family N-acetyltransferase-
ASZ82_RS16665420246..420683+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ82_RS16670420747..420965+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ82_RS16680421140..422012+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304736..427674122938
-insideIntegron--309816..427298117482
flankIS/Tn--420246..420683437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T58252 WP_000118351.1 NZ_CP013304:416803-417336 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T58252 NZ_CP013304:416803-417336 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT58252 WP_001882332.1 NZ_CP013304:416381-416806 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT58252 NZ_CP013304:416381-416806 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References