58239

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 332922..333460 Replicon chromosome
Accession NZ_CP013304
Organism Vibrio cholerae strain CRC711

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ82_RS15775 Protein ID WP_000802136.1
Coordinates 332922..333221 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ82_RS15780 Protein ID WP_001107719.1
Coordinates 333218..333460 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ82_RS15715 328127..328309 + 183 WP_000923340.1 DUF645 family protein -
ASZ82_RS15720 328524..329063 + 540 WP_000099372.1 hypothetical protein -
ASZ82_RS15725 329186..329701 + 516 WP_000090011.1 hypothetical protein -
ASZ82_RS15730 329836..330372 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ82_RS20420 330491..330652 + 162 WP_000481782.1 hypothetical protein -
ASZ82_RS15735 330841..330951 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ82_RS15745 331164..331316 + 153 WP_001884520.1 DUF645 family protein -
ASZ82_RS15750 331600..332043 + 444 WP_000803902.1 hypothetical protein -
ASZ82_RS15755 332047..332157 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ82_RS15760 332187..332465 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ82_RS15765 332462..332746 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ82_RS15775 332922..333221 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ82_RS15780 333218..333460 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ82_RS15790 333879..333956 + 78 WP_071908337.1 DUF645 family protein -
ASZ82_RS20350 333960..333986 + 27 Protein_299 hypothetical protein -
ASZ82_RS20425 334572..334715 + 144 WP_001900215.1 hypothetical protein -
ASZ82_RS20010 334809..334988 + 180 Protein_301 DUF645 family protein -
ASZ82_RS15815 335206..335634 + 429 WP_000620002.1 N-acetyltransferase -
ASZ82_RS15825 336222..336704 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ82_RS15835 337512..337781 + 270 WP_001114075.1 DUF4160 domain-containing protein -
ASZ82_RS15840 337775..338296 + 522 WP_000921692.1 DUF2442 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304736..427674 122938
- inside Integron - - 309816..427298 117482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58239 WP_000802136.1 NZ_CP013304:c333221-332922 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58239 NZ_CP013304:c333221-332922 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58239 WP_001107719.1 NZ_CP013304:c333460-333218 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58239 NZ_CP013304:c333460-333218 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References