Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 325566..326332 | Replicon | chromosome |
| Accession | NZ_CP013304 | ||
| Organism | Vibrio cholerae strain CRC711 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A233HKB4 |
| Locus tag | ASZ82_RS15690 | Protein ID | WP_000982256.1 |
| Coordinates | 325566..326063 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | ASZ82_RS15695 | Protein ID | WP_000246254.1 |
| Coordinates | 326060..326332 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ82_RS15655 | 320966..321505 | + | 540 | WP_053035032.1 | phosphoglycerate mutase family protein | - |
| ASZ82_RS15660 | 321640..322065 | + | 426 | WP_000693748.1 | hypothetical protein | - |
| ASZ82_RS20410 | 322122..322232 | + | 111 | WP_106746893.1 | iron transporter | - |
| ASZ82_RS15665 | 322219..322578 | + | 360 | WP_001071527.1 | VOC family protein | - |
| ASZ82_RS20505 | 322720..323153 | + | 434 | Protein_277 | GNAT family N-acetyltransferase | - |
| ASZ82_RS15675 | 323290..324216 | + | 927 | WP_000377813.1 | hypothetical protein | - |
| ASZ82_RS19975 | 324539..324692 | + | 154 | Protein_279 | DUF645 family protein | - |
| ASZ82_RS15685 | 324921..325424 | + | 504 | WP_001158950.1 | DinB family protein | - |
| ASZ82_RS15690 | 325566..326063 | - | 498 | WP_000982256.1 | GNAT family N-acetyltransferase | Toxin |
| ASZ82_RS15695 | 326060..326332 | - | 273 | WP_000246254.1 | DUF1778 domain-containing protein | Antitoxin |
| ASZ82_RS15700 | 326720..326887 | + | 168 | WP_053035038.1 | DUF645 family protein | - |
| ASZ82_RS15705 | 327095..327442 | + | 348 | WP_000933413.1 | hypothetical protein | - |
| ASZ82_RS15715 | 328127..328309 | + | 183 | WP_000923340.1 | DUF645 family protein | - |
| ASZ82_RS15720 | 328524..329063 | + | 540 | WP_000099372.1 | hypothetical protein | - |
| ASZ82_RS15725 | 329186..329701 | + | 516 | WP_000090011.1 | hypothetical protein | - |
| ASZ82_RS15730 | 329836..330372 | + | 537 | WP_000644491.1 | nucleotidyltransferase family protein | - |
| ASZ82_RS20420 | 330491..330652 | + | 162 | WP_000481782.1 | hypothetical protein | - |
| ASZ82_RS15735 | 330841..330951 | + | 111 | WP_071908335.1 | DUF3265 domain-containing protein | - |
| ASZ82_RS15745 | 331164..331316 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 304736..427674 | 122938 | |
| - | inside | Integron | - | - | 309816..427298 | 117482 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18539.23 Da Isoelectric Point: 8.7753
>T58237 WP_000982256.1 NZ_CP013304:c326063-325566 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T58237 NZ_CP013304:c326063-325566 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCATTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACACCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCTTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCGCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTGATCGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCTGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCATTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACACCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCTTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCGCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTGATCGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCTGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9685.19 Da Isoelectric Point: 6.2988
>AT58237 WP_000246254.1 NZ_CP013304:c326332-326060 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT58237 NZ_CP013304:c326332-326060 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCACTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATTGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCACTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATTGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|