58240

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 337512..338296 Replicon chromosome
Accession NZ_CP013304
Organism Vibrio cholerae strain CRC711

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ82_RS15835 Protein ID WP_001114075.1
Coordinates 337512..337781 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag ASZ82_RS15840 Protein ID WP_000921692.1
Coordinates 337775..338296 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ82_RS15775 332922..333221 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ82_RS15780 333218..333460 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
ASZ82_RS15790 333879..333956 + 78 WP_071908337.1 DUF645 family protein -
ASZ82_RS20350 333960..333986 + 27 Protein_299 hypothetical protein -
ASZ82_RS20425 334572..334715 + 144 WP_001900215.1 hypothetical protein -
ASZ82_RS20010 334809..334988 + 180 Protein_301 DUF645 family protein -
ASZ82_RS15815 335206..335634 + 429 WP_000620002.1 N-acetyltransferase -
ASZ82_RS15825 336222..336704 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ82_RS15835 337512..337781 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
ASZ82_RS15840 337775..338296 + 522 WP_000921692.1 DUF2442 domain-containing protein Antitoxin
ASZ82_RS15845 338353..338466 + 114 WP_001894981.1 hypothetical protein -
ASZ82_RS15850 338435..339271 + 837 WP_000242986.1 hypothetical protein -
ASZ82_RS15855 339436..340074 + 639 WP_000230118.1 HD domain-containing protein -
ASZ82_RS20030 340164..340324 + 161 Protein_309 DUF3709 domain-containing protein -
ASZ82_RS15860 340345..340566 + 222 WP_012705854.1 DUF3709 domain-containing protein -
ASZ82_RS15870 340886..341206 + 321 WP_001909340.1 DUF1778 domain-containing protein -
ASZ82_RS15875 341203..341736 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ82_RS15880 341974..342252 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ82_RS15885 342653..342877 + 225 WP_001894423.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304736..427674 122938
- inside Integron - - 309816..427298 117482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58240 WP_001114075.1 NZ_CP013304:337512-337781 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58240 NZ_CP013304:337512-337781 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT58240 WP_000921692.1 NZ_CP013304:337775-338296 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58240 NZ_CP013304:337775-338296 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB C3LUY7

References