Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 332187..332746 | Replicon | chromosome |
| Accession | NZ_CP013304 | ||
| Organism | Vibrio cholerae strain CRC711 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9K2M8 |
| Locus tag | ASZ82_RS15760 | Protein ID | WP_000578476.1 |
| Coordinates | 332187..332465 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | ASZ82_RS15765 | Protein ID | WP_000381183.1 |
| Coordinates | 332462..332746 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ASZ82_RS15715 | 328127..328309 | + | 183 | WP_000923340.1 | DUF645 family protein | - |
| ASZ82_RS15720 | 328524..329063 | + | 540 | WP_000099372.1 | hypothetical protein | - |
| ASZ82_RS15725 | 329186..329701 | + | 516 | WP_000090011.1 | hypothetical protein | - |
| ASZ82_RS15730 | 329836..330372 | + | 537 | WP_000644491.1 | nucleotidyltransferase family protein | - |
| ASZ82_RS20420 | 330491..330652 | + | 162 | WP_000481782.1 | hypothetical protein | - |
| ASZ82_RS15735 | 330841..330951 | + | 111 | WP_071908335.1 | DUF3265 domain-containing protein | - |
| ASZ82_RS15745 | 331164..331316 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
| ASZ82_RS15750 | 331600..332043 | + | 444 | WP_000803902.1 | hypothetical protein | - |
| ASZ82_RS15755 | 332047..332157 | + | 111 | WP_071908336.1 | DUF3265 domain-containing protein | - |
| ASZ82_RS15760 | 332187..332465 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| ASZ82_RS15765 | 332462..332746 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| ASZ82_RS15775 | 332922..333221 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ASZ82_RS15780 | 333218..333460 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| ASZ82_RS15790 | 333879..333956 | + | 78 | WP_071908337.1 | DUF645 family protein | - |
| ASZ82_RS20350 | 333960..333986 | + | 27 | Protein_299 | hypothetical protein | - |
| ASZ82_RS20425 | 334572..334715 | + | 144 | WP_001900215.1 | hypothetical protein | - |
| ASZ82_RS20010 | 334809..334988 | + | 180 | Protein_301 | DUF645 family protein | - |
| ASZ82_RS15815 | 335206..335634 | + | 429 | WP_000620002.1 | N-acetyltransferase | - |
| ASZ82_RS15825 | 336222..336704 | + | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 304736..427674 | 122938 | |
| - | inside | Integron | - | - | 309816..427298 | 117482 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T58238 WP_000578476.1 NZ_CP013304:c332465-332187 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T58238 NZ_CP013304:c332465-332187 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT58238 WP_000381183.1 NZ_CP013304:c332746-332462 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT58238 NZ_CP013304:c332746-332462 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9K2M8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |