Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/comX2   Type   Regulator
Locus tag   R8623_RS00070 Genome accession   NZ_AP026928
Coordinates   14255..14734 (+) Length   159 a.a.
NCBI ID   WP_000588925.1    Uniprot ID   A0AAX3HEV8
Organism   Streptococcus pneumoniae strain PZ900700406     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 12175..44018 14255..14734 within 0


Gene organization within MGE regions


Location: 12175..44018
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8623_RS00065 (PC0401_00130) ftsH 12175..14133 (+) 1959 WP_000744557.1 ATP-dependent zinc metalloprotease FtsH -
  R8623_RS00070 (PC0401_00140) comX/comX2 14255..14734 (+) 480 WP_000588925.1 sigma-70 family RNA polymerase sigma factor Regulator
  R8623_RS00105 - 20225..21071 (+) 847 Protein_14 IS630 family transposase -
  R8623_RS00110 - 21106..21903 (-) 798 Protein_15 transposase -
  R8623_RS00115 (PC0401_00180) comW 22169..22405 (+) 237 WP_000939544.1 sigma(X)-activator ComW Regulator
  R8623_RS00120 (PC0401_00190) - 22636..23922 (+) 1287 WP_000205044.1 adenylosuccinate synthase -
  R8623_RS00125 (PC0401_00200) tadA 24123..24590 (+) 468 WP_000291870.1 tRNA adenosine(34) deaminase TadA -
  R8623_RS00135 (PC0401_00210) - 24799..25497 (-) 699 WP_001106362.1 site-specific integrase -
  R8623_RS00140 (PC0401_00220) - 25587..25940 (-) 354 WP_001814135.1 hypothetical protein -
  R8623_RS00145 (PC0401_00230) - 25995..27059 (-) 1065 WP_061374999.1 type I restriction endonuclease -
  R8623_RS00150 (PC0401_00240) - 27076..27456 (-) 381 WP_000170931.1 ImmA/IrrE family metallo-endopeptidase -
  R8623_RS00155 (PC0401_00250) - 27469..27732 (-) 264 WP_000285962.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R8623_RS00160 (PC0401_00260) - 27732..27965 (-) 234 WP_000156419.1 hypothetical protein -
  R8623_RS00165 (PC0401_00270) - 27965..28333 (-) 369 WP_000464160.1 helix-turn-helix domain-containing protein -
  R8623_RS00170 (PC0401_00290) - 28905..29096 (+) 192 WP_001112859.1 DNA-binding protein -
  R8623_RS00175 (PC0401_00300) - 29119..29322 (+) 204 WP_001247549.1 hypothetical protein -
  R8623_RS00180 (PC0401_00320) - 29477..29644 (-) 168 WP_000024181.1 YjzC family protein -
  R8623_RS00185 (PC0401_00330) - 29649..30029 (+) 381 Protein_29 autolysin -
  R8623_RS00190 (PC0401_00340) - 30249..30428 (-) 180 WP_001209433.1 hypothetical protein -
  R8623_RS00195 (PC0401_00350) - 30570..30719 (-) 150 WP_001030863.1 hypothetical protein -
  R8623_RS00200 (PC0401_00360) - 31024..31467 (+) 444 WP_000701992.1 dUTP diphosphatase -
  R8623_RS00205 (PC0401_00370) - 31469..31984 (+) 516 WP_000691236.1 histidine phosphatase family protein -
  R8623_RS00210 (PC0401_00380) radA 31998..33359 (+) 1362 WP_075213698.1 DNA repair protein RadA Machinery gene
  R8623_RS00215 (PC0401_00390) - 33432..33929 (+) 498 WP_001809263.1 carbonic anhydrase -
  R8623_RS00220 (PC0401_00400) - 33954..34737 (+) 784 Protein_36 PrsW family glutamic-type intramembrane protease -
  R8623_RS00225 (PC0401_00410) - 34882..35850 (+) 969 WP_000010157.1 ribose-phosphate diphosphokinase -
  R8623_RS00230 - 35984..36265 (-) 282 Protein_38 ISL3 family transposase -
  R8623_RS00235 - 36392..37274 (-) 883 Protein_39 Rpn family recombination-promoting nuclease/putative transposase -
  R8623_RS00240 (PC0401_00440) polA 37530..40163 (+) 2634 WP_317649668.1 DNA polymerase I -
  R8623_RS00245 (PC0401_00450) - 40248..40685 (+) 438 WP_000076483.1 CoA-binding protein -
  R8623_RS00250 (PC0401_00460) - 40923..41933 (-) 1011 WP_000009141.1 YeiH family protein -
  R8623_RS00255 (PC0401_00480) - 42082..43251 (+) 1170 WP_000366376.1 pyridoxal phosphate-dependent aminotransferase -
  R8623_RS00260 (PC0401_00490) recO 43248..44018 (+) 771 WP_000616164.1 DNA repair protein RecO -

Sequence

Protein


Download         Length: 159 a.a.        Molecular weight: 19887.54 Da        Isoelectric Point: 7.3798

>NTDB_id=98557 R8623_RS00070 WP_000588925.1 14255..14734(+) (comX/comX2) [Streptococcus pneumoniae strain PZ900700406]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWEQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide


Download         Length: 480 bp        

>NTDB_id=98557 R8623_RS00070 WP_000588925.1 14255..14734(+) (comX/comX2) [Streptococcus pneumoniae strain PZ900700406]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGAGCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAGACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAACAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCATTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/comX2 Streptococcus pneumoniae TIGR4

100

100

1
  comX/comX1 Streptococcus pneumoniae TIGR4

100

100

1
  comX/comX2 Streptococcus pneumoniae Rx1

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae Rx1

99.371

100

0.994
  comX/comX2 Streptococcus pneumoniae D39

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae D39

99.371

100

0.994
  comX/comX2 Streptococcus pneumoniae R6

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae R6

99.371

100

0.994
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

91.824

100

0.918
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

91.824

100

0.918
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

89.937

100

0.899
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

88.608

99.371

0.881
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comX/sigX Streptococcus suis D9

46.358

94.969

0.44
  comX/sigX Streptococcus suis isolate S10

46.358

94.969

0.44
  comX/sigX Streptococcus suis P1/7

46.358

94.969

0.44
  comX/sigX Streptococcus mutans UA159

46

94.34

0.434
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

94.34

0.377
  comX Streptococcus salivarius SK126

38.926

93.711

0.365
  comX Streptococcus thermophilus LMG 18311

38.926

93.711

0.365
  comX Streptococcus thermophilus LMD-9

38.926

93.711

0.365

Multiple sequence alignment