Detailed information NTG0049768

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: SSUD12_RS00780
• Genome accession: NC_017621
• Coordinates: 127126..127407 (+)
• Length: 93 a.a.
• NCBI ID: WP_002936550.1
• Uniprot ID: G7SD61
• Organism: Streptococcus suis D12
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 122126..132407

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSUD12_RS00760 (SSUD12_0121)	-	123789..124154 (+)	366	WP_014637310.1	DUF1033 family protein	-
SSUD12_RS00765 (SSUD12_0122)	-	124189..125139 (-)	951	WP_014637311.1	S66 peptidase family protein	-
SSUD12_RS00770 (SSUD12_0123)	comYA	125225..126175 (+)	951	WP_014637312.1	competence type IV pilus ATPase ComGA	Machinery gene
SSUD12_RS00775 (SSUD12_0124)	comYB	126087..127124 (+)	1038	WP_044669087.1	competence type IV pilus assembly protein ComGB	Machinery gene
SSUD12_RS00780 (SSUD12_0125)	comYC	127126..127407 (+)	282	WP_002936550.1	competence type IV pilus major pilin ComGC	Machinery gene
SSUD12_RS00785 (SSUD12_0126)	comGD	127388..127795 (+)	408	WP_014637314.1	competence type IV pilus minor pilin ComGD	-
SSUD12_RS00790 (SSUD12_0127)	comYE	127767..128060 (+)	294	WP_024410167.1	competence type IV pilus minor pilin ComGE	Machinery gene
SSUD12_RS00795 (SSUD12_0128)	comGF/cglF	128047..128481 (+)	435	WP_014637316.1	competence type IV pilus minor pilin ComGF	Machinery gene
SSUD12_RS00800 (SSUD12_0129)	comGG	128459..128869 (+)	411	WP_014637317.1	competence type IV pilus minor pilin ComGG	-
SSUD12_RS00805 (SSUD12_0130)	comYH	128926..129879 (+)	954	WP_014637318.1	class I SAM-dependent methyltransferase	Machinery gene
SSUD12_RS00810 (SSUD12_0131)	-	129929..131116 (+)	1188	WP_014637319.1	acetate kinase	-
SSUD12_RS00815 (SSUD12_0132)	-	131377..131928 (+)	552	WP_014637320.1	folate family ECF transporter S component	-

Sequence

Protein

• Length: 93 a.a.
• Molecular weight: 10452.31 Da
• Isoelectric Point: 5.1667

>NTDB_id=49768 SSUD12_RS00780 WP_002936550.1 127126..127407(+) (comYC) [Streptococcus suis D12]
MKKLVEMKVKGFTLVEMLVVLGIISLLLLLFVPNLSKQKDAVQEKGNAAVVKVVESQMELYELEHDEEATVEDLQQAGYI
TEKQAKQYATAKK

Nucleotide

• Length: 282 bp

>NTDB_id=49768 SSUD12_RS00780 WP_002936550.1 127126..127407(+) (comYC) [Streptococcus suis D12]
ATGAAAAAATTAGTTGAAATGAAGGTAAAAGGGTTCACTCTGGTGGAAATGTTAGTCGTTTTGGGGATCATTAGCCTGCT
CTTGCTCTTATTTGTGCCAAATTTGAGCAAACAAAAGGATGCTGTTCAAGAGAAAGGAAATGCGGCTGTTGTCAAAGTAG
TGGAGAGTCAGATGGAGCTCTATGAATTGGAACATGACGAGGAAGCAACGGTGGAGGATTTGCAACAGGCAGGTTATATT
ACTGAAAAACAAGCAAAACAGTATGCTACGGCGAAAAAATAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (8-30)

3D structure

• AlphaFold DB: G7SD61

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus suis isolate S10	92.473	100	0.925
comGC/cglC	Streptococcus pneumoniae TIGR4	68.182	94.624	0.645
comGC/cglC	Streptococcus pneumoniae Rx1	68.182	94.624	0.645
comGC/cglC	Streptococcus pneumoniae D39	68.182	94.624	0.645
comGC/cglC	Streptococcus pneumoniae R6	68.182	94.624	0.645
comGC/cglC	Streptococcus mitis SK321	69.412	91.398	0.634
comGC/cglC	Streptococcus mitis NCTC 12261	69.412	91.398	0.634
comYC	Streptococcus gordonii str. Challis substr. CH1	65.169	95.699	0.624
comYC	Streptococcus mutans UA140	61.364	94.624	0.581
comYC	Streptococcus mutans UA159	61.364	94.624	0.581
comGC	Lactococcus lactis subsp. cremoris KW2	59.091	94.624	0.559
comGC	Staphylococcus aureus MW2	50	83.871	0.419
comGC	Staphylococcus aureus N315	50	83.871	0.419
comGC	Bacillus subtilis subsp. subtilis str. 168	46.667	80.645	0.376