Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/comX2   Type   Regulator
Locus tag   GL189_RS00060 Genome accession   NZ_CP046360
Coordinates   12219..12698 (+) Length   159 a.a.
NCBI ID   WP_000588925.1    Uniprot ID   A0AAX3HEV8
Organism   Streptococcus pneumoniae strain 574     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 9581..38133 12219..12698 within 0


Gene organization within MGE regions


Location: 9581..38133
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL189_RS00050 (GL189_00050) hpt 9581..10123 (+) 543 WP_000892185.1 hypoxanthine phosphoribosyltransferase -
  GL189_RS00055 (GL189_00055) ftsH 10139..12097 (+) 1959 WP_000744557.1 ATP-dependent zinc metalloprotease FtsH -
  GL189_RS00060 (GL189_00060) comX/comX2 12219..12698 (+) 480 WP_000588925.1 sigma-70 family RNA polymerase sigma factor Regulator
  GL189_RS00095 (GL189_00095) - 18189..19035 (+) 847 Protein_13 IS630 family transposase -
  GL189_RS00100 (GL189_00100) - 19070..19867 (-) 798 Protein_14 transposase -
  GL189_RS00105 (GL189_00105) comW 20133..20369 (+) 237 WP_000939544.1 sigma(X)-activator ComW Regulator
  GL189_RS00110 (GL189_00110) - 20600..21886 (+) 1287 WP_000205044.1 adenylosuccinate synthase -
  GL189_RS00115 (GL189_00115) tadA 22087..22554 (+) 468 WP_000291870.1 tRNA adenosine(34) deaminase TadA -
  GL189_RS10715 (GL189_00125) - 22763..23461 (-) 699 WP_001106362.1 tyrosine-type recombinase/integrase -
  GL189_RS10720 (GL189_00130) - 23551..23898 (-) 348 WP_001839379.1 hypothetical protein -
  GL189_RS00130 (GL189_00135) - 23959..25029 (-) 1071 WP_000401841.1 type I restriction endonuclease -
  GL189_RS00135 (GL189_00140) - 25046..25426 (-) 381 WP_000170931.1 ImmA/IrrE family metallo-endopeptidase -
  GL189_RS00140 (GL189_00145) - 25439..25702 (-) 264 WP_000285962.1 type II toxin-antitoxin system RelE family toxin -
  GL189_RS00145 (GL189_00150) - 25702..25935 (-) 234 WP_000156419.1 hypothetical protein -
  GL189_RS00150 (GL189_00155) - 25935..26303 (-) 369 WP_000464160.1 helix-turn-helix domain-containing protein -
  GL189_RS00155 (GL189_00160) - 26875..27066 (+) 192 WP_001112859.1 DNA-binding protein -
  GL189_RS00160 (GL189_00165) - 27089..27292 (+) 204 WP_001247549.1 hypothetical protein -
  GL189_RS00165 (GL189_00170) - 27447..27614 (-) 168 WP_000024181.1 YjzC family protein -
  GL189_RS00170 (GL189_00175) - 27619..27999 (+) 381 Protein_28 autolysin -
  GL189_RS00175 (GL189_00180) - 28219..28398 (-) 180 WP_001209433.1 hypothetical protein -
  GL189_RS00180 - 28540..28689 (-) 150 WP_001030863.1 hypothetical protein -
  GL189_RS00185 (GL189_00185) - 28994..29437 (+) 444 WP_000701992.1 dUTP diphosphatase -
  GL189_RS00190 (GL189_00190) - 29439..29954 (+) 516 WP_000691236.1 histidine phosphatase family protein -
  GL189_RS00195 (GL189_00195) radA 29968..31329 (+) 1362 WP_075213698.1 DNA repair protein RadA Machinery gene
  GL189_RS00200 (GL189_00200) - 31402..31899 (+) 498 WP_001809263.1 beta-class carbonic anhydrase -
  GL189_RS00205 (GL189_00205) - 31924..32707 (+) 784 Protein_35 PrsW family glutamic-type intramembrane protease -
  GL189_RS00210 (GL189_00210) - 32852..33820 (+) 969 WP_000010157.1 ribose-phosphate diphosphokinase -
  GL189_RS00215 (GL189_00215) - 33954..34235 (-) 282 Protein_37 transposase family protein -
  GL189_RS10700 - 34362..35244 (-) 883 Protein_38 Rpn family recombination-promoting nuclease/putative transposase -
  GL189_RS00235 (GL189_00235) polA 35500..38133 (+) 2634 WP_024477951.1 DNA polymerase I -

Sequence

Protein


Download         Length: 159 a.a.        Molecular weight: 19887.54 Da        Isoelectric Point: 7.3798

>NTDB_id=403382 GL189_RS00060 WP_000588925.1 12219..12698(+) (comX/comX2) [Streptococcus pneumoniae strain 574]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWEQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide


Download         Length: 480 bp        

>NTDB_id=403382 GL189_RS00060 WP_000588925.1 12219..12698(+) (comX/comX2) [Streptococcus pneumoniae strain 574]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGAGCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAGACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAACAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCATTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/comX2 Streptococcus pneumoniae TIGR4

100

100

1
  comX/comX1 Streptococcus pneumoniae TIGR4

100

100

1
  comX/comX2 Streptococcus pneumoniae Rx1

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae Rx1

99.371

100

0.994
  comX/comX2 Streptococcus pneumoniae D39

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae D39

99.371

100

0.994
  comX/comX2 Streptococcus pneumoniae R6

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae R6

99.371

100

0.994
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

91.824

100

0.918
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

91.824

100

0.918
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

89.937

100

0.899
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

88.608

99.371

0.881
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comX/sigX Streptococcus suis D9

46.358

94.969

0.44
  comX/sigX Streptococcus suis isolate S10

46.358

94.969

0.44
  comX/sigX Streptococcus suis P1/7

46.358

94.969

0.44
  comX/sigX Streptococcus mutans UA159

46

94.34

0.434
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

94.34

0.377
  comX Streptococcus salivarius SK126

38.926

93.711

0.365
  comX Streptococcus thermophilus LMG 18311

38.926

93.711

0.365
  comX Streptococcus thermophilus LMD-9

38.926

93.711

0.365

Multiple sequence alignment