Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/comX2   Type   Regulator
Locus tag   GL184_RS10880 Genome accession   NZ_CP046356
Coordinates   2129354..2129833 (-) Length   159 a.a.
NCBI ID   WP_000588925.1    Uniprot ID   A0AAX3HEV8
Organism   Streptococcus pneumoniae strain 521     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2099791..2131913 2129354..2129833 within 0


Gene organization within MGE regions


Location: 2099791..2131913
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL184_RS10675 (GL184_10845) recO 2099791..2100561 (-) 771 WP_000616164.1 DNA repair protein RecO -
  GL184_RS10680 (GL184_10850) - 2100558..2101727 (-) 1170 WP_000366342.1 pyridoxal phosphate-dependent aminotransferase -
  GL184_RS10685 (GL184_10855) - 2101876..2102886 (+) 1011 WP_000009171.1 YeiH family protein -
  GL184_RS11315 - 2102905..2103300 (-) 396 WP_061826320.1 hypothetical protein -
  GL184_RS10695 (GL184_10865) - 2103341..2103778 (-) 438 WP_061633093.1 CoA-binding protein -
  GL184_RS10700 (GL184_10870) polA 2103863..2106496 (-) 2634 WP_088834530.1 DNA polymerase I -
  GL184_RS10940 - 2106752..2107659 (+) 908 Protein_2096 Rpn family recombination-promoting nuclease/putative transposase -
  GL184_RS10720 (GL184_10890) - 2107786..2108067 (+) 282 Protein_2097 ISL3 family transposase -
  GL184_RS10725 (GL184_10895) - 2108201..2109169 (-) 969 WP_000010163.1 ribose-phosphate diphosphokinase -
  GL184_RS10730 (GL184_10900) - 2109314..2110128 (-) 815 Protein_2099 PrsW family intramembrane metalloprotease -
  GL184_RS10740 (GL184_10905) - 2110153..2110650 (-) 498 WP_001809263.1 beta-class carbonic anhydrase -
  GL184_RS10745 (GL184_10910) radA 2110723..2112084 (-) 1362 WP_074017595.1 DNA repair protein RadA Machinery gene
  GL184_RS10750 (GL184_10915) - 2112098..2112613 (-) 516 WP_000691236.1 histidine phosphatase family protein -
  GL184_RS10755 (GL184_10920) - 2112615..2113058 (-) 444 WP_000701992.1 dUTP diphosphatase -
  GL184_RS10760 - 2113363..2113512 (+) 150 WP_001030863.1 hypothetical protein -
  GL184_RS10765 (GL184_10925) - 2113654..2113833 (+) 180 WP_001209433.1 hypothetical protein -
  GL184_RS10770 (GL184_10930) - 2114053..2114433 (-) 381 Protein_2106 autolysin -
  GL184_RS10775 (GL184_10935) - 2114438..2114605 (+) 168 WP_000024181.1 YjzC family protein -
  GL184_RS10780 (GL184_10940) - 2114760..2114963 (-) 204 WP_001247549.1 hypothetical protein -
  GL184_RS10785 (GL184_10945) - 2114986..2115177 (-) 192 WP_001112859.1 DNA-binding protein -
  GL184_RS10790 (GL184_10950) - 2115749..2116117 (+) 369 WP_000464160.1 helix-turn-helix domain-containing protein -
  GL184_RS10795 (GL184_10955) - 2116117..2116350 (+) 234 WP_000156419.1 hypothetical protein -
  GL184_RS10800 (GL184_10960) - 2116350..2116613 (+) 264 WP_000285962.1 type II toxin-antitoxin system RelE family toxin -
  GL184_RS10805 (GL184_10965) - 2116626..2117006 (+) 381 WP_000170931.1 ImmA/IrrE family metallo-endopeptidase -
  GL184_RS10810 (GL184_10970) - 2117023..2118093 (+) 1071 WP_000401841.1 type I restriction endonuclease -
  GL184_RS11320 (GL184_10975) - 2118154..2118501 (+) 348 WP_001839379.1 hypothetical protein -
  GL184_RS11325 (GL184_10980) - 2118591..2119289 (+) 699 WP_001106362.1 tyrosine-type recombinase/integrase -
  GL184_RS10825 (GL184_10990) tadA 2119498..2119965 (-) 468 WP_000291870.1 tRNA adenosine(34) deaminase TadA -
  GL184_RS10830 (GL184_10995) - 2120166..2121452 (-) 1287 WP_000205044.1 adenylosuccinate synthase -
  GL184_RS10835 (GL184_11000) comW 2121683..2121919 (-) 237 WP_000939544.1 sigma(X)-activator ComW Regulator
  GL184_RS10840 (GL184_11005) - 2122185..2122982 (+) 798 Protein_2120 transposase -
  GL184_RS10845 (GL184_11010) - 2123017..2123863 (-) 847 Protein_2121 IS630 family transposase -
  GL184_RS10880 (GL184_11045) comX/comX2 2129354..2129833 (-) 480 WP_000588925.1 sigma-70 family RNA polymerase sigma factor Regulator
  GL184_RS10885 (GL184_11050) ftsH 2129955..2131913 (-) 1959 WP_000744557.1 ATP-dependent zinc metalloprotease FtsH -

Sequence

Protein


Download         Length: 159 a.a.        Molecular weight: 19887.54 Da        Isoelectric Point: 7.3798

>NTDB_id=403147 GL184_RS10880 WP_000588925.1 2129354..2129833(-) (comX/comX2) [Streptococcus pneumoniae strain 521]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWEQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide


Download         Length: 480 bp        

>NTDB_id=403147 GL184_RS10880 WP_000588925.1 2129354..2129833(-) (comX/comX2) [Streptococcus pneumoniae strain 521]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGAGCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAGACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAACAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCATTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/comX2 Streptococcus pneumoniae TIGR4

100

100

1
  comX/comX1 Streptococcus pneumoniae TIGR4

100

100

1
  comX/comX2 Streptococcus pneumoniae Rx1

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae Rx1

99.371

100

0.994
  comX/comX2 Streptococcus pneumoniae D39

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae D39

99.371

100

0.994
  comX/comX2 Streptococcus pneumoniae R6

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae R6

99.371

100

0.994
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

91.824

100

0.918
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

91.824

100

0.918
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

89.937

100

0.899
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

88.608

99.371

0.881
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comX/sigX Streptococcus suis D9

46.358

94.969

0.44
  comX/sigX Streptococcus suis isolate S10

46.358

94.969

0.44
  comX/sigX Streptococcus suis P1/7

46.358

94.969

0.44
  comX/sigX Streptococcus mutans UA159

46

94.34

0.434
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

94.34

0.377
  comX Streptococcus salivarius SK126

38.926

93.711

0.365
  comX Streptococcus thermophilus LMG 18311

38.926

93.711

0.365
  comX Streptococcus thermophilus LMD-9

38.926

93.711

0.365

Multiple sequence alignment