Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 30188..30780 | Replicon | plasmid pJIE143 |
| Accession | JN194214 | ||
| Organism | Escherichia coli strain JIE143 transconjugant Tx143 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 30532..30780 (-) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 30188..30535 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Locus_26 | 26191..26517 | - | 327 | AEQ61766.1 | Pilx2 | - |
| Locus_27 | 26531..27151 | - | 621 | AEQ61767.1 | Pilx1 | - |
| Locus_28 | 27154..27330 | - | 177 | AEQ61792.1 | conserved hypothetical protein | - |
| Locus_29 | 27509..27724 | - | 216 | AEQ61782.1 | putative Eex entry exclusion protein | - |
| Locus_30 | 27721..28014 | - | 294 | AEQ61793.1 | conserved hypothetical protein | - |
| Locus_31 | 28091..29320 | - | 1230 | AEQ61771.1 | TaxC DNA relaxase/nickase | - |
| Locus_32 | 29324..29827 | - | 504 | AEQ61783.1 | TaxA | - |
| Locus_33 | 30188..30535 | - | 348 | AEQ61773.1 | putative HicB toxin-antitoxin system protein | Antitoxin |
| Locus_34 | 30532..30780 | - | 249 | AEQ61772.1 | putative HicA toxin-antitoxin system protein | Toxin |
| Locus_35 | 31085..31450 | - | 366 | AEQ61791.1 | conserved hypothetical protein | - |
| Locus_36 | 31526..31867 | - | 342 | AEQ61790.1 | conserved hypothetical protein | - |
| Locus_37 | 31827..32186 | - | 360 | AEQ61789.1 | conserved hypothetical protein | - |
| Locus_38 | 32279..32506 | - | 228 | AEQ61788.1 | conserved hypothetical protein | - |
| Locus_39 | 32493..32744 | - | 252 | AEQ61787.1 | conserved hypothetical protein | - |
| Locus_40 | 32741..33283 | - | 543 | AEQ61786.1 | conserved hypothetical protein | - |
| Locus_41 | 33388..34266 | - | 879 | AEQ61770.1 | DnaJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Non-Mobilizable plasmid | blaCTX-M-15 | - | 1..34345 | 34345 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9422.08 Da Isoelectric Point: 10.4800
>T10150 - JN194214:c30780-30532 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
Download Length: 249 bp
>T10150 JN194214:c30780-30532 [Escherichia coli]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13113.84 Da Isoelectric Point: 4.6723
>AT10150 - JN194214:c30535-30188 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
Download Length: 348 bp
>AT10150 JN194214:c30535-30188 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Paula Bustamante et al. (2019) The roles of HicBA and a novel toxin-antitoxin-like system, TsxAB, in the stability of IncX4 resistance plasmids in Escherichia coli. The Journal of Antimicrobial Chemotherapy 74(3):553-556. [PubMed:30535076]