114487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 12449..13041 Replicon plasmid unnamed3
Accession NZ_CP033849
Organism Escherichia coli strain FDAARGOS_497

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag EGY17_RS01665 Protein ID WP_000520549.1
Coordinates 12449..12697 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag EGY17_RS01670 Protein ID WP_000681613.1
Coordinates 12694..13041 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY17_RS01630 9326..9841 + 516 WP_001025395.1 J domain-containing protein -
EGY17_RS01635 9946..10488 + 543 WP_001083906.1 hypothetical protein -
EGY17_RS01640 10485..10736 + 252 WP_001230707.1 hypothetical protein -
EGY17_RS01645 10723..10950 + 228 WP_000801440.1 hypothetical protein -
EGY17_RS01655 11404..11703 + 300 WP_000650309.1 hypothetical protein -
EGY17_RS01660 11794..12144 + 351 WP_000854259.1 hypothetical protein -
EGY17_RS01665 12449..12697 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
EGY17_RS01670 12694..13041 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGY17_RS01680 13403..13906 + 504 WP_000781813.1 hypothetical protein -
EGY17_RS01685 13910..15139 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
EGY17_RS01690 15216..15509 + 294 WP_000134733.1 LuxR family transcriptional regulator -
EGY17_RS01695 15506..15721 + 216 WP_000760375.1 EexN family lipoprotein -
EGY17_RS01700 16078..16698 + 621 WP_000157548.1 lytic transglycosylase domain-containing protein -
EGY17_RS01705 16766..17038 + 273 WP_001329503.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..32101 32101


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T114487 WP_000520549.1 NZ_CP033849:12449-12697 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

>T114487 NZ_CP033849:12449-12697 [Escherichia coli]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT114487 WP_000681613.1 NZ_CP033849:12694-13041 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp

>AT114487 NZ_CP033849:12694-13041 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References