114486

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 10485..10950 Replicon plasmid unnamed3
Accession NZ_CP033849
Organism Escherichia coli strain FDAARGOS_497

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag EGY17_RS01640 Protein ID WP_001230707.1
Coordinates 10485..10736 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag EGY17_RS01645 Protein ID WP_000801440.1
Coordinates 10723..10950 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY17_RS01615 5966..6493 - 528 WP_000577043.1 DUF2726 domain-containing protein -
EGY17_RS01620 6628..7032 - 405 WP_012421203.1 hypothetical protein -
EGY17_RS01625 7045..7911 - 867 WP_001353743.1 replication initiation protein -
EGY17_RS01630 9326..9841 + 516 WP_001025395.1 J domain-containing protein -
EGY17_RS01635 9946..10488 + 543 WP_001083906.1 hypothetical protein -
EGY17_RS01640 10485..10736 + 252 WP_001230707.1 hypothetical protein Toxin
EGY17_RS01645 10723..10950 + 228 WP_000801440.1 hypothetical protein Antitoxin
EGY17_RS01655 11404..11703 + 300 WP_000650309.1 hypothetical protein -
EGY17_RS01660 11794..12144 + 351 WP_000854259.1 hypothetical protein -
EGY17_RS01665 12449..12697 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
EGY17_RS01670 12694..13041 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
EGY17_RS01680 13403..13906 + 504 WP_000781813.1 hypothetical protein -
EGY17_RS01685 13910..15139 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
EGY17_RS01690 15216..15509 + 294 WP_000134733.1 LuxR family transcriptional regulator -
EGY17_RS01695 15506..15721 + 216 WP_000760375.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..32101 32101


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T114486 WP_001230707.1 NZ_CP033849:10485-10736 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T114486 NZ_CP033849:10485-10736 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT114486 WP_000801440.1 NZ_CP033849:10723-10950 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT114486 NZ_CP033849:10723-10950 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References