296536

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6501..7093 Replicon plasmid P4
Accession NZ_OX030705
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag LQ128_RS26345 Protein ID WP_000520549.1
Coordinates 6501..6749 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag LQ128_RS26350 Protein ID WP_000681613.1
Coordinates 6746..7093 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS26315 (AI2951V1_5062) 3378..3893 + 516 WP_001025395.1 J domain-containing protein -
LQ128_RS26320 (AI2951V1_5063) 3998..4540 + 543 WP_001083906.1 hypothetical protein -
LQ128_RS26325 (AI2951V1_5064) 4537..4788 + 252 WP_001230707.1 hypothetical protein -
LQ128_RS26330 (AI2951V1_5065) 4775..5002 + 228 WP_000801440.1 hypothetical protein -
LQ128_RS26335 (AI2951V1_5066) 5456..5755 + 300 WP_000650309.1 hypothetical protein -
LQ128_RS26340 (AI2951V1_5067) 5846..6196 + 351 WP_000854259.1 hypothetical protein -
LQ128_RS26345 (AI2951V1_5069) 6501..6749 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ128_RS26350 (AI2951V1_5070) 6746..7093 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ128_RS26355 (AI2951V1_5071) 7454..7957 + 504 WP_000781813.1 relaxosome-coupling protein TaxA -
LQ128_RS26360 (AI2951V1_5072) 7961..9190 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
LQ128_RS26365 (AI2951V1_5073) 9267..9560 + 294 WP_000134733.1 sigma factor-like helix-turn-helix DNA-binding protein -
LQ128_RS26370 (AI2951V1_5074) 9557..9772 + 216 WP_000760375.1 EexN family lipoprotein -
LQ128_RS26375 (AI2951V1_5076) 10130..10750 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
LQ128_RS26380 (AI2951V1_5077) 10764..11090 + 327 WP_000008647.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..31765 31765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T296536 WP_000520549.1 NZ_OX030705:6501-6749 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT296536 WP_000681613.1 NZ_OX030705:6746-7093 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References