Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 3397852..3398014 | Replicon | chromosome |
| Accession | NC_009089 | ||
| Organism | Clostridium difficile 630 | ||
| T1TAdb ID | TA07134 | ||
Toxin (Protein)
| Gene name | CD2907.2 | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 3397910..3398014 (-) | Length | 35 a.a. |
Antitoxin (RNA)
| Gene name | RCd15 | ||
| Locus tag | - | ||
| Coordinates | 3397852..3397957 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 3375898..3428859 | 52961 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 35 a.a. Molecular weight: 3747.45 Da Isoelectric Point: 9.7388
>T10084 - NC_009089:c3398014-3397910 [Clostridioides difficile 630]
MIGFLLSILAGVISAYIYDKIKNHPDANKGDLKK
MIGFLLSILAGVISAYIYDKIKNHPDANKGDLKK
Download Length: 105 bp
>T10084 NC_009089:c3398014-3397910 [Clostridioides difficile 630]
ATGATAGGTTTTTTATTAAGCATACTAGCTGGTGTTATATCAGCTTATATTTATGACAAAATAAAAAATCACCCAGACGC
CAATAAGGGTGATTTAAAAAAATAA
ATGATAGGTTTTTTATTAAGCATACTAGCTGGTGTTATATCAGCTTATATTTATGACAAAATAAAAAATCACCCAGACGC
CAATAAGGGTGATTTAAAAAAATAA
Antitoxin
Download Length: 106 bp
>AT10084 NC_009089:3397852-3397957 [Clostridioides difficile 630]
AAGGAAATAATTTACTTTATACAAGAGTAGCTATTTCCATCAAAATTGATTTAAAGAATTATTTTTTTAAATCACCCTTA
TTGGCGTCTGGGTGATTTTTTATTTT
AAGGAAATAATTTACTTTATACAAGAGTAGCTATTTCCATCAAAATTGATTTAAAGAATTATTTTTTTAAATCACCCTTA
TTGGCGTCTGGGTGATTTTTTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10083 | Clostridium difficile 630 |
100 |
100 |
1 |
| T10082 | Clostridium difficile 630 |
79.412 |
100 |
0.794 |
| T10176 | Clostridium difficile 630 |
40 |
100 |
0.471 |
| T10172 | Clostridium difficile 630 |
35.135 |
100 |
0.382 |
| T10173 | Clostridium difficile 630 |
35.135 |
100 |
0.382 |
| T10081 | Clostridium difficile 630 |
30.556 |
100 |
0.324 |
| T10080 | Clostridium difficile 630 |
30.556 |
100 |
0.324 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Johann Peltier et al. (2020) Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile. Communications Biology 3(1):718. [PubMed:33247281]