Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 3364734..3364949 Replicon chromosome
Accession NZ_CP010905
Organism Clostridioides difficile 630

Toxin (Protein)


Gene name CD2889 Uniprot ID Q183X5
Locus tag CDIF630_RS20600 Protein ID WP_011861731.1
Coordinates 3364806..3364949 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 3364734..3364880 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630_RS15815 3360393..3361547 + 1155 WP_003439713.1 GGDEF domain-containing protein -
CDIF630_RS15820 3361628..3363346 - 1719 WP_011861730.1 putative 2-aminoethylphosphonate ABC transporter permease subunit -
CDIF630_RS15825 3363351..3364232 - 882 Protein_2976 ATP-binding cassette domain-containing protein -
- 3364734..3364880 + 147 NuclAT_2 - Antitoxin
- 3364734..3364884 + 151 NuclAT_1 - -
CDIF630_RS20600 3364806..3364949 - 144 WP_011861731.1 hypothetical protein Toxin
CDIF630_RS15835 3365207..3365395 + 189 WP_009898401.1 hypothetical protein -
CDIF630_RS15840 3365642..3366346 - 705 WP_011861732.1 hypothetical protein -
CDIF630_RS15845 3366348..3366779 - 432 WP_011861052.1 protein-export chaperone SecB -
CDIF630_RS15850 3366797..3367360 - 564 WP_021371073.1 hypothetical protein -
CDIF630_RS15855 3367906..3368202 - 297 WP_011861049.1 hypothetical protein -
CDIF630_RS15860 3368219..3369034 - 816 WP_011861048.1 N-acetylmuramoyl-L-alanine amidase -
CDIF630_RS15865 3369031..3369291 - 261 WP_011861047.1 phage holin family protein -
CDIF630_RS15870 3369311..3369541 - 231 WP_011861046.1 hemolysin XhlA family protein -
CDIF630_RS15875 3369576..3369758 - 183 WP_011861045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3360426..3413387 52961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5399.34 Da        Isoelectric Point: 10.8277

>T53093 WP_011861731.1 NZ_CP010905:c3364949-3364806 [Clostridioides difficile 630]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH

Download         Length: 144 bp

>T53093 NZ_CP010905:c3364949-3364806 [Clostridioides difficile 630]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA

Antitoxin


Download         Length: 147 bp

>AT53093 NZ_CP010905:3364734-3364880 [Clostridioides difficile 630]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A3R1

Antitoxin

Download structure file

References