Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 3382830..3383044 Replicon chromosome
Accession NZ_CP010905
Organism Clostridioides difficile 630

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CDIF630_RS20605 Protein ID WP_003429855.1
Coordinates 3382883..3383044 (-) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 3382830..3382963 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630_RS15930 3380046..3380615 - 570 WP_011861035.1 zinc-ribbon domain-containing protein -
CDIF630_RS15935 3380659..3381219 - 561 WP_011861034.1 lipoprotein -
- 3382380..3382485 + 106 NuclAT_12 - -
- 3382380..3382485 + 106 NuclAT_14 - -
- 3382830..3382963 + 134 NuclAT_6 - Antitoxin
- 3382830..3382963 + 134 NuclAT_8 - Antitoxin
CDIF630_RS20605 3382883..3383044 - 162 WP_003429855.1 hypothetical protein Toxin
CDIF630_RS15950 3383385..3383825 - 441 WP_003429853.1 phage portal protein -
CDIF630_RS15955 3383897..3384367 - 471 WP_003429851.1 phage tail tube protein -
CDIF630_RS15960 3384384..3385694 - 1311 WP_011861032.1 phage tail sheath family protein -
CDIF630_RS20610 3385696..3385872 - 177 WP_011861031.1 hypothetical protein -
CDIF630_RS15970 3385865..3386302 - 438 WP_009901504.1 hypothetical protein -
CDIF630_RS15975 3386295..3386720 - 426 WP_011861030.1 HK97 gp10 family phage protein -
CDIF630_RS15980 3386720..3387067 - 348 WP_003429844.1 hypothetical protein -
CDIF630_RS15985 3387061..3387462 - 402 WP_009888836.1 hypothetical protein -
CDIF630_RS15990 3387472..3387705 - 234 WP_009896624.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3360426..3413387 52961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T53097 WP_003429855.1 NZ_CP010905:c3383044-3382883 [Clostridioides difficile 630]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T53097 NZ_CP010905:c3383044-3382883 [Clostridioides difficile 630]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin


Download         Length: 134 bp

>AT53097 NZ_CP010905:3382830-3382963 [Clostridioides difficile 630]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References