Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 3355522..3355736 Replicon chromosome
Accession NZ_CP016318
Organism Clostridioides difficile strain 630 delta erm

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CDIF630erm_RS20765 Protein ID WP_003429855.1
Coordinates 3355575..3355736 (-) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 3355522..3355655 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630erm_RS15815 3352738..3353307 - 570 WP_011861035.1 zinc-ribbon domain-containing protein -
CDIF630erm_RS15820 3353351..3353911 - 561 WP_011861034.1 lipoprotein -
- 3355072..3355177 + 106 NuclAT_12 - -
- 3355072..3355177 + 106 NuclAT_14 - -
- 3355522..3355655 + 134 NuclAT_6 - Antitoxin
- 3355522..3355655 + 134 NuclAT_8 - Antitoxin
CDIF630erm_RS20765 3355575..3355736 - 162 WP_003429855.1 hypothetical protein Toxin
CDIF630erm_RS15835 3356077..3356517 - 441 WP_003429853.1 phage portal protein -
CDIF630erm_RS15840 3356589..3357059 - 471 WP_003429851.1 phage tail tube protein -
CDIF630erm_RS15845 3357076..3358386 - 1311 WP_011861032.1 phage tail sheath family protein -
CDIF630erm_RS20770 3358388..3358564 - 177 WP_011861031.1 hypothetical protein -
CDIF630erm_RS15855 3358557..3358994 - 438 WP_009901504.1 hypothetical protein -
CDIF630erm_RS15860 3358987..3359412 - 426 WP_011861030.1 HK97 gp10 family phage protein -
CDIF630erm_RS15865 3359412..3359759 - 348 WP_003429844.1 hypothetical protein -
CDIF630erm_RS15870 3359753..3360154 - 402 WP_009888836.1 hypothetical protein -
CDIF630erm_RS15875 3360164..3360397 - 234 WP_009896624.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3337899..3386079 48180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T64419 WP_003429855.1 NZ_CP016318:c3355736-3355575 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T64419 NZ_CP016318:c3355736-3355575 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin


Download         Length: 134 bp

>AT64419 NZ_CP016318:3355522-3355655 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References