Detailed information    

insolico Bioinformatically predicted

Overview


Name   comX/comX2   Type   Regulator
Locus tag   ABC804_RS00325 Genome accession   NZ_CP155536
Coordinates   45261..45740 (-) Length   159 a.a.
NCBI ID   WP_000588866.1    Uniprot ID   A0A6C7J1A1
Organism   Streptococcus pneumoniae strain M264-3     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1253..47820 45261..45740 within 0


Gene organization within MGE regions


Location: 1253..47820
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC804_RS00015 (ABC804_00015) - 1253..1696 (-) 444 WP_000701992.1 dUTP diphosphatase -
  ABC804_RS00025 (ABC804_00025) tadA 1882..2349 (-) 468 WP_000291870.1 tRNA adenosine(34) deaminase TadA -
  ABC804_RS00030 (ABC804_00030) - 2917..3105 (+) 189 WP_000109850.1 hypothetical protein -
  ABC804_RS00035 (ABC804_00035) - 3326..4282 (-) 957 WP_000350505.1 N-acetylmuramoyl-L-alanine amidase family protein -
  ABC804_RS00040 (ABC804_00040) - 4286..4618 (-) 333 WP_001186219.1 phage holin -
  ABC804_RS00045 (ABC804_00045) - 4622..5038 (-) 417 WP_001165344.1 phage holin family protein -
  ABC804_RS00050 (ABC804_00050) - 5047..5397 (-) 351 WP_000852241.1 hypothetical protein -
  ABC804_RS00055 (ABC804_00055) - 5400..5603 (-) 204 WP_001091113.1 hypothetical protein -
  ABC804_RS00060 (ABC804_00060) - 5584..5700 (-) 117 WP_001063632.1 hypothetical protein -
  ABC804_RS00065 (ABC804_00065) - 5697..12329 (-) 6633 WP_000966215.1 phage tail spike protein -
  ABC804_RS00070 (ABC804_00070) - 12330..13052 (-) 723 WP_000589856.1 hypothetical protein -
  ABC804_RS00075 (ABC804_00075) - 13049..16144 (-) 3096 WP_000918318.1 hypothetical protein -
  ABC804_RS00080 (ABC804_00080) - 16422..16841 (-) 420 WP_001227146.1 hypothetical protein -
  ABC804_RS00085 (ABC804_00085) - 16853..17431 (-) 579 WP_000191279.1 major tail protein -
  ABC804_RS00090 (ABC804_00090) - 17443..17766 (-) 324 WP_000777003.1 hypothetical protein -
  ABC804_RS00095 (ABC804_00095) - 17763..18110 (-) 348 WP_000063886.1 HK97 gp10 family phage protein -
  ABC804_RS00100 (ABC804_00100) - 18107..18406 (-) 300 WP_000267055.1 phage head closure protein -
  ABC804_RS00105 (ABC804_00105) - 18393..18674 (-) 282 WP_000370976.1 hypothetical protein -
  ABC804_RS00110 (ABC804_00110) - 18677..18946 (-) 270 WP_000262606.1 hypothetical protein -
  ABC804_RS00115 (ABC804_00115) - 18958..20124 (-) 1167 WP_001030357.1 phage major capsid protein -
  ABC804_RS00120 (ABC804_00120) - 20121..20696 (-) 576 WP_001172115.1 HK97 family phage prohead protease -
  ABC804_RS00125 (ABC804_00125) - 20680..21882 (-) 1203 WP_000510803.1 phage portal protein -
  ABC804_RS00130 (ABC804_00130) - 21900..22118 (-) 219 WP_001002923.1 hypothetical protein -
  ABC804_RS00135 (ABC804_00135) - 22126..23856 (-) 1731 WP_000527299.1 terminase large subunit -
  ABC804_RS00140 (ABC804_00140) - 23849..24241 (-) 393 WP_001118283.1 P27 family phage terminase small subunit -
  ABC804_RS00145 (ABC804_00145) - 24378..24698 (-) 321 WP_000282427.1 HNH endonuclease -
  ABC804_RS00150 (ABC804_00150) - 25075..25617 (-) 543 WP_000397549.1 site-specific integrase -
  ABC804_RS00155 (ABC804_00155) - 25805..26206 (-) 402 WP_000736390.1 transcriptional activator -
  ABC804_RS00160 (ABC804_00160) - 26383..26457 (-) 75 Protein_30 DUF1642 domain-containing protein -
  ABC804_RS00165 (ABC804_00165) - 26459..26776 (-) 318 WP_000969665.1 hypothetical protein -
  ABC804_RS00170 (ABC804_00170) - 26748..26957 (-) 210 WP_000872740.1 hypothetical protein -
  ABC804_RS00175 (ABC804_00175) - 26944..27111 (-) 168 WP_000233203.1 hypothetical protein -
  ABC804_RS00180 (ABC804_00180) - 27125..27223 (-) 99 Protein_34 single-stranded DNA-binding protein -
  ABC804_RS00185 (ABC804_00185) - 27605..27823 (-) 219 WP_000891962.1 hypothetical protein -
  ABC804_RS00190 (ABC804_00190) - 27823..28017 (-) 195 WP_000470307.1 hypothetical protein -
  ABC804_RS00195 (ABC804_00195) - 28032..28802 (-) 771 WP_000228219.1 ATP-binding protein -
  ABC804_RS00200 (ABC804_00200) - 28942..29748 (-) 807 WP_001289771.1 phage replisome organizer N-terminal domain-containing protein -
  ABC804_RS00205 (ABC804_00205) - 29741..30037 (-) 297 WP_000391805.1 hypothetical protein -
  ABC804_RS00210 (ABC804_00210) - 30053..30373 (-) 321 WP_000462824.1 hypothetical protein -
  ABC804_RS00215 (ABC804_00215) - 30459..30716 (-) 258 WP_000370959.1 hypothetical protein -
  ABC804_RS00220 (ABC804_00220) - 30730..31440 (-) 711 WP_001002359.1 ORF6C domain-containing protein -
  ABC804_RS00225 (ABC804_00225) - 31494..31919 (+) 426 WP_000386249.1 hypothetical protein -
  ABC804_RS00230 (ABC804_00230) - 31914..32075 (-) 162 WP_001002946.1 hypothetical protein -
  ABC804_RS00235 (ABC804_00235) - 32086..32283 (-) 198 WP_001057654.1 hypothetical protein -
  ABC804_RS00240 (ABC804_00240) - 32300..32503 (-) 204 WP_000032097.1 helix-turn-helix transcriptional regulator -
  ABC804_RS00245 (ABC804_00245) - 32515..32661 (-) 147 WP_000389576.1 hypothetical protein -
  ABC804_RS00250 (ABC804_00250) - 32780..33001 (+) 222 WP_000041097.1 hypothetical protein -
  ABC804_RS00255 (ABC804_00255) - 33378..33743 (+) 366 WP_000492031.1 helix-turn-helix transcriptional regulator -
  ABC804_RS00260 (ABC804_00260) - 33756..34139 (+) 384 WP_000136459.1 ImmA/IrrE family metallo-endopeptidase -
  ABC804_RS00265 (ABC804_00265) - 34152..35075 (+) 924 WP_000122591.1 exonuclease domain-containing protein -
  ABC804_RS00270 (ABC804_00270) - 35261..36409 (+) 1149 WP_000876732.1 site-specific integrase -
  ABC804_RS00275 (ABC804_00275) - 36651..37937 (-) 1287 WP_000205044.1 adenylosuccinate synthase -
  ABC804_RS00280 (ABC804_00280) comW 38168..38404 (-) 237 WP_000939546.1 sigma(X)-activator ComW Regulator
  ABC804_RS00285 (ABC804_00285) - 38670..39467 (+) 798 Protein_55 transposase -
  ABC804_RS00290 (ABC804_00290) - 39502..39711 (-) 210 Protein_56 transposase -
  ABC804_RS00325 (ABC804_00325) comX/comX2 45261..45740 (-) 480 WP_000588866.1 sigma-70 family RNA polymerase sigma factor Regulator
  ABC804_RS00330 (ABC804_00330) ftsH 45862..47820 (-) 1959 WP_000744554.1 ATP-dependent zinc metalloprotease FtsH -

Sequence


Protein


Download         Length: 159 a.a.        Molecular weight: 19845.46 Da        Isoelectric Point: 7.3797

>NTDB_id=997381 ABC804_RS00325 WP_000588866.1 45261..45740(-) (comX/comX2) [Streptococcus pneumoniae strain M264-3]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLADDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGELSHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide


Download         Length: 480 bp        

>NTDB_id=997381 ABC804_RS00325 WP_000588866.1 45261..45740(-) (comX/comX2) [Streptococcus pneumoniae strain M264-3]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGCAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGCTCAGTCATCGTATAAGTGAGGGAGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG

Domains



No domain identified.



Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A6C7J1A1

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/comX2 Streptococcus pneumoniae Rx1

98.742

100

0.987

  comX/comX1 Streptococcus pneumoniae Rx1

98.742

100

0.987

  comX/comX2 Streptococcus pneumoniae D39

98.742

100

0.987

  comX/comX1 Streptococcus pneumoniae D39

98.742

100

0.987

  comX/comX2 Streptococcus pneumoniae R6

98.742

100

0.987

  comX/comX1 Streptococcus pneumoniae R6

98.742

100

0.987

  comX/comX2 Streptococcus pneumoniae TIGR4

98.113

100

0.981

  comX/comX1 Streptococcus pneumoniae TIGR4

98.113

100

0.981

  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

91.195

100

0.912

  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

91.195

100

0.912

  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

89.308

100

0.893

  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

89.241

99.371

0.887

  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

48.077

98.113

0.472

  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

48.077

98.113

0.472

  comX/sigX Streptococcus suis D9

45.695

94.969

0.434

  comX/sigX Streptococcus suis isolate S10

45.695

94.969

0.434

  comX/sigX Streptococcus suis P1/7

45.695

94.969

0.434

  comX/sigX Streptococcus mutans UA159

45.333

94.34

0.428

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

39.216

96.226

0.377

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

39.216

96.226

0.377

  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

94.34

0.377

  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

94.34

0.377

  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

94.34

0.377

  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

94.34

0.377

  comX Streptococcus sobrinus strain NIDR 6715-7

38.926

93.711

0.365


Multiple sequence alignment