Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE2   Type   Regulator
Locus tag   I872_RS10615 Genome accession   NC_021175
Coordinates   2136577..2137320 (-) Length   247 a.a.
NCBI ID   WP_005591384.1    Uniprot ID   A0AAV3EGB4
Organism   Streptococcus cristatus AS 1.3089     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2131577..2142320
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I872_RS10580 (I872_10635) - 2132155..2132994 (+) 840 WP_015606083.1 energy-coupling factor ABC transporter ATP-binding protein -
  I872_RS10585 (I872_10640) - 2132987..2133781 (+) 795 WP_015606084.1 energy-coupling factor transporter transmembrane component T family protein -
  I872_RS10590 (I872_10645) - 2133967..2134623 (+) 657 WP_015606085.1 LysM peptidoglycan-binding domain-containing protein -
  I872_RS10595 (I872_10650) sdaAA 2134681..2135553 (-) 873 WP_015606086.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -
  I872_RS10600 (I872_10655) sdaAB 2135562..2136233 (-) 672 WP_015606087.1 L-serine ammonia-lyase, iron-sulfur-dependent subunit beta -
  I872_RS10615 (I872_10660) comE/comE2 2136577..2137320 (-) 744 WP_005591384.1 competence system response regulator transcription factor ComE Regulator
  I872_RS10620 (I872_10665) comD/comD1 2137317..2138660 (-) 1344 WP_172456456.1 GHKL domain-containing protein Regulator
  I872_RS10625 comC 2138686..2138814 (-) 129 WP_041826850.1 competence protein Regulator
  I872_RS10635 (I872_10670) rlmH 2139108..2139587 (-) 480 WP_015606089.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I872_RS10640 (I872_10675) htrA 2139790..2140968 (+) 1179 WP_015606090.1 S1C family serine protease Regulator
  I872_RS10645 (I872_10680) spo0J 2141031..2141792 (+) 762 WP_015606091.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 29125.42 Da        Isoelectric Point: 7.3958

>NTDB_id=58490 I872_RS10615 WP_005591384.1 2136577..2137320(-) (comE/comE2) [Streptococcus cristatus AS 1.3089]
MRILALEDTLAHQLRMEKTLAEIAEEMGLDIQVKITGKIQEFKDYVENEDVNQIYFLDIDIKGEETKGLEVARFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINDDSFKKRIKECIIYTKNTLITNTNMVDYFEYSYRGNDVRVPFNDILY
IETSSSSHKLRMVGKNFIKEFYGTIASVQEQDEKTQRFFASHKSFLVNIDNICDYDKKTKEIIFYEGRRCPVSRLRTKHL
KEILKNK

Nucleotide


Download         Length: 744 bp        

>NTDB_id=58490 I872_RS10615 WP_005591384.1 2136577..2137320(-) (comE/comE2) [Streptococcus cristatus AS 1.3089]
ATGAGAATCTTAGCATTAGAAGATACTTTAGCTCACCAACTCCGCATGGAAAAAACTTTAGCAGAGATTGCTGAAGAAAT
GGGGCTCGATATCCAGGTCAAAATCACAGGAAAAATTCAGGAATTTAAGGACTATGTCGAAAATGAAGATGTCAATCAGA
TTTATTTTCTGGATATAGATATTAAAGGGGAAGAGACCAAAGGATTGGAGGTCGCTCGTTTTATTCGTCATCATAATCCA
TACGCCATTATTGTCTTTGTAACTTCAAAATCAGAGTTTGCGACCATGACCTTCAAATATAAGGTATCTGCTCTTGACTT
TATTGATAAGGATATTAACGATGATTCGTTTAAAAAACGTATAAAAGAGTGTATCATTTATACGAAAAATACTCTAATAA
CAAACACCAATATGGTTGATTATTTTGAATATAGCTATCGAGGCAATGATGTGCGCGTGCCATTTAACGATATTTTGTAT
ATCGAAACCTCAAGCTCCTCTCATAAGTTACGAATGGTTGGAAAAAACTTTATAAAGGAATTTTATGGAACAATTGCCAG
TGTTCAAGAGCAGGATGAGAAAACCCAACGTTTCTTTGCTTCTCATAAATCTTTCTTAGTCAATATCGATAATATCTGCG
ATTATGATAAGAAAACAAAGGAAATTATATTTTATGAAGGCCGTCGTTGCCCTGTTTCCAGGCTAAGAACAAAACATTTA
AAAGAAATTTTAAAAAATAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(18-121)

LytTr DNA-binding domain (LytTR)

(151-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

68.421

100

0.684
  comE/comE2 Streptococcus gordonii strain NCTC7865

68.421

100

0.684
  comE Streptococcus mitis NCTC 12261

62.348

100

0.623
  comE Streptococcus mitis SK321

61.538

100

0.615
  comE Streptococcus pneumoniae TIGR4

61.134

100

0.611
  comE Streptococcus pneumoniae D39

61.134

100

0.611
  comE Streptococcus infantis strain Atu-4

61.134

100

0.611
  comE Streptococcus pneumoniae Rx1

61.134

100

0.611
  comE Streptococcus pneumoniae R6

61.134

100

0.611
  comE/blpR Streptococcus mutans UA159

39.919

100

0.401
  comE/comE1 Streptococcus equinus JB1

38.306

100

0.385
  comE/comE2 Streptococcus equinus JB1

37.551

99.19

0.372

Multiple sequence alignment