Detailed information NTG0058493

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: I872_RS10640
• Genome accession: NC_021175
• Coordinates: 2139790..2140968 (+)
• Length: 392 a.a.
• NCBI ID: WP_015606090.1
• Uniprot ID: -
• Organism: Streptococcus cristatus AS 1.3089
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2134790..2145968

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I872_RS10600 (I872_10655)	sdaAB	2135562..2136233 (-)	672	WP_015606087.1	L-serine ammonia-lyase, iron-sulfur-dependent subunit beta	-
I872_RS10615 (I872_10660)	comE/comE2	2136577..2137320 (-)	744	WP_005591384.1	competence system response regulator transcription factor ComE	Regulator
I872_RS10620 (I872_10665)	comD/comD1	2137317..2138660 (-)	1344	WP_172456456.1	GHKL domain-containing protein	Regulator
I872_RS10625	comC	2138686..2138814 (-)	129	WP_041826850.1	competence protein	Regulator
I872_RS10635 (I872_10670)	rlmH	2139108..2139587 (-)	480	WP_015606089.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I872_RS10640 (I872_10675)	htrA	2139790..2140968 (+)	1179	WP_015606090.1	S1C family serine protease	Regulator
I872_RS10645 (I872_10680)	spo0J	2141031..2141792 (+)	762	WP_015606091.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 392 a.a.
• Molecular weight: 41335.44 Da
• Isoelectric Point: 5.4758

>NTDB_id=58493 I872_RS10640 WP_015606090.1 2139790..2140968(+) (htrA) [Streptococcus cristatus AS 1.3089]
MKNASNFFKKSLLLFIVLVVGFIGGSLGNLATAFLNNKMANIGPSSSKTTVSTSYKNTTDTTKAVKKVQNAVVSVITYTG
SNQEGVINNESTSDPQVASEGSGVIYKKEGKYAYLVTNTHVLNGATNPDILLADGSKVPGEVVGSDVYSDISVVRINSEK
VKDVAEFGDSNSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSEDGQNISTTALQTDAAINPGNSGGPLINIQ
GQVIGITSSKISHNGQTAVEGMGFAIPSNDVVNIIKQLEKTGTVTRPALGIQMLDLSNIATSDLSKLRLPSSVKSGILVR
SVQEGMPAENKLQKYDVITKVDDKDVESTSDLQSALYRHSLGDELKVTYFRDGKEATTTIKLTKSTQDLSDN

Nucleotide

• Length: 1179 bp

>NTDB_id=58493 I872_RS10640 WP_015606090.1 2139790..2140968(+) (htrA) [Streptococcus cristatus AS 1.3089]
ATGAAAAACGCTTCAAATTTCTTTAAAAAATCTTTGTTGCTTTTTATTGTTTTAGTTGTAGGATTTATTGGCGGAAGCCT
AGGAAATTTAGCCACTGCATTTCTTAATAATAAAATGGCTAATATTGGTCCTTCTAGCTCAAAGACCACTGTATCAACGT
CTTATAAAAACACAACCGACACCACAAAGGCTGTAAAAAAGGTTCAAAATGCAGTTGTATCAGTAATTACTTATACAGGT
TCAAATCAAGAAGGAGTGATCAATAATGAATCAACCAGTGATCCTCAAGTAGCTAGTGAGGGATCTGGTGTTATTTATAA
GAAGGAAGGAAAATATGCCTACCTTGTTACCAATACTCACGTGCTAAATGGAGCAACAAATCCTGATATTCTACTAGCAG
ATGGTAGTAAGGTTCCTGGTGAGGTCGTTGGTTCAGATGTTTATTCTGATATTTCTGTAGTAAGAATTAACTCTGAAAAG
GTGAAAGATGTAGCTGAATTTGGAGATTCCAACTCCCTGACAGTAGGAGAAACTGCTATTGCCATCGGAAGCCCTCTCGG
AACAGAATACGCTAACTCTGTTACACAAGGAATCATCTCTAGTTTAGGCAGAAATGTAACTCTCCAATCTGAAGACGGCC
AAAATATTTCCACAACTGCCTTGCAAACAGATGCTGCTATCAACCCTGGTAACTCTGGCGGTCCACTCATCAATATCCAA
GGACAAGTTATCGGTATTACGTCCAGCAAAATCTCTCACAATGGTCAAACTGCTGTAGAAGGCATGGGCTTTGCAATTCC
ATCAAACGATGTTGTCAATATTATCAAGCAATTAGAGAAAACTGGAACAGTAACTCGTCCTGCTCTGGGTATCCAAATGC
TCGATTTATCTAATATCGCCACTTCTGACTTATCAAAATTACGTCTGCCTTCATCTGTAAAATCAGGTATCCTTGTCCGC
TCTGTGCAAGAAGGAATGCCTGCTGAAAATAAACTTCAGAAATACGATGTCATCACAAAAGTTGACGATAAGGATGTTGA
GTCAACCAGTGATTTACAATCTGCTCTCTACAGACACTCTCTGGGAGATGAGTTGAAAGTGACTTACTTTAGGGATGGTA
AAGAAGCTACTACAACCATTAAATTGACCAAATCAACCCAGGACTTAAGTGACAACTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (287-382)

• Peptidase family M50 (Peptidase_M50) (233-386)

• Trypsin-like peptidase domain (Trypsin_2) (101-246)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	67.595	100	0.681
htrA	Streptococcus pneumoniae Rx1	63.939	99.745	0.638
htrA	Streptococcus pneumoniae D39	63.939	99.745	0.638
htrA	Streptococcus pneumoniae R6	63.939	99.745	0.638
htrA	Streptococcus pneumoniae TIGR4	63.939	99.745	0.638
htrA	Streptococcus mitis NCTC 12261	63.939	99.745	0.638
htrA	Streptococcus mutans UA159	54.342	100	0.559