Detailed information NTG0506509

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: I2435_RS08925
• Genome accession: NZ_CP065059
• Coordinates: 1850344..1850829 (-)
• Length: 161 a.a.
• NCBI ID: WP_012677392.1
• Uniprot ID: A0A380JSU6
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ25
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1851144..1852278	1850344..1850829	flank	315

Gene organization within MGE regions

Location: 1850344..1852278

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2435_RS08925 (JFMEOBDD_01800)	comX/sigX/comX2/sigX2	1850344..1850829 (-)	486	WP_012677392.1	hypothetical protein	Regulator
I2435_RS08935 (JFMEOBDD_01803)	-	1851144..1852278 (-)	1135	Protein_1719	ISAs1 family transposase	-

Sequence

Protein

• Length: 161 a.a.
• Molecular weight: 19371.39 Da
• Isoelectric Point: 7.3119

>NTDB_id=506509 I2435_RS08925 WP_012677392.1 1850344..1850829(-) (comX/sigX/comX2/sigX2) [Streptococcus equi subsp. zooepidemicus strain SEZ25]
MSDDLVRLFDKIKPIIMKLRRHYYIQLWELDDWLQEGRLILYRLLVTYPELIEDEEKLYRYFKTKFSSYLKDVLRQQESQ
KRRFHKMAYEEIGAVGHAIPAGGLGVDDYVAYQLIVKEVEEQLTESELLQFRALIRGERFEGRRALLRKIGPYFQDFTGE
K

Nucleotide

• Length: 486 bp

>NTDB_id=506509 I2435_RS08925 WP_012677392.1 1850344..1850829(-) (comX/sigX/comX2/sigX2) [Streptococcus equi subsp. zooepidemicus strain SEZ25]
ATGAGTGATGATTTAGTGAGGTTGTTTGATAAGATCAAGCCTATTATTATGAAGCTAAGACGGCATTATTATATTCAGCT
GTGGGAGCTAGATGATTGGTTACAGGAGGGGCGGTTGATCTTGTATCGGTTATTGGTCACTTATCCAGAATTGATAGAGG
ATGAGGAGAAGCTGTACCGTTATTTTAAGACCAAGTTTTCCTCTTATTTGAAGGACGTGTTGCGGCAGCAGGAGAGTCAG
AAGCGTCGGTTTCATAAGATGGCTTATGAGGAGATTGGGGCGGTAGGGCATGCGATACCAGCAGGTGGCTTGGGAGTAGA
TGATTATGTGGCTTATCAGTTGATTGTGAAGGAGGTTGAGGAGCAATTGACAGAGAGCGAGCTGTTACAGTTTAGGGCTT
TGATCAGGGGAGAGCGGTTTGAGGGGAGACGGGCCTTGCTTCGCAAGATAGGACCTTACTTTCAGGACTTTACTGGTGAG
AAATAA

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A380JSU6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	68.75	99.379	0.683
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	68.75	99.379	0.683
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	68.75	99.379	0.683
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	68.75	99.379	0.683
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	68.75	99.379	0.683
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	68.75	99.379	0.683
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	48.387	96.273	0.466
comX/sigX	Streptococcus mutans UA159	46.497	97.516	0.453
comX	Streptococcus sobrinus strain NIDR 6715-7	45.752	95.031	0.435
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	40.667	93.168	0.379
comX	Streptococcus thermophilus LMD-9	39.216	95.031	0.373
comX	Streptococcus thermophilus LMG 18311	39.216	95.031	0.373
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	39.735	93.789	0.373
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	39.735	93.789	0.373
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	39.333	93.168	0.366
comX/comX2	Streptococcus pneumoniae Rx1	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae Rx1	38.411	93.789	0.36
comX/comX2	Streptococcus pneumoniae D39	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae D39	38.411	93.789	0.36
comX/comX2	Streptococcus pneumoniae R6	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae R6	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae TIGR4	38.411	93.789	0.36
comX/comX2	Streptococcus pneumoniae TIGR4	38.411	93.789	0.36
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	38.667	93.168	0.36