Detailed information NTG0000306

Bioinformatically predicted

Overview

• Name: comGC
• Type: Machinery gene
• Locus tag: STER_RS08990
• Genome accession: NC_008532
• Coordinates: 1710438..1710764 (-)
• Length: 108 a.a.
• NCBI ID: WP_002946126.1
• Uniprot ID: A0A0E2Q1B3
• Organism: Streptococcus thermophilus LMD-9
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1705438..1715764

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STER_RS11960 (STER_1831)	-	1705704..1706042 (-)	339	WP_224103197.1	CPBP family intramembrane glutamic endopeptidase	-
STER_RS11965 (STER_1832)	-	1706086..1706361 (-)	276	WP_011681681.1	hypothetical protein	-
STER_RS08955 (STER_1833)	-	1706373..1706570 (-)	198	WP_011681682.1	helix-turn-helix transcriptional regulator	-
STER_RS08960 (STER_1834)	-	1706819..1708012 (-)	1194	WP_011681683.1	acetate kinase	-
STER_RS08965 (STER_1835)	comYH	1708068..1709024 (-)	957	WP_011681684.1	class I SAM-dependent methyltransferase	Machinery gene
STER_RS08970 (STER_1836)	comGG	1709069..1709386 (-)	318	WP_011681685.1	competence type IV pilus minor pilin ComGG	Machinery gene
STER_RS08975 (STER_1837)	comGF	1709364..1709801 (-)	438	WP_011681686.1	competence type IV pilus minor pilin ComGF	Machinery gene
STER_RS08980 (STER_1838)	comGE	1709785..1710078 (-)	294	WP_011226625.1	competence type IV pilus minor pilin ComGE	Machinery gene
STER_RS08985 (STER_1839)	comGD	1710050..1710478 (-)	429	WP_011226626.1	competence type IV pilus minor pilin ComGD	Machinery gene
STER_RS08990 (STER_1840)	comGC	1710438..1710764 (-)	327	WP_002946126.1	competence type IV pilus major pilin ComGC	Machinery gene
STER_RS08995 (STER_1841)	comGB	1710761..1711861 (-)	1101	WP_120764773.1	competence type IV pilus assembly protein ComGB	Machinery gene
STER_RS09000 (STER_1842)	comGA	1711743..1712684 (-)	942	WP_011681689.1	competence type IV pilus ATPase ComGA	Machinery gene
STER_RS09005 (STER_1843)	-	1712765..1713127 (-)	363	WP_011226630.1	DUF1033 family protein	-

Sequence

Protein

• Length: 108 a.a.
• Molecular weight: 11914.00 Da
• Isoelectric Point: 9.9219

>NTDB_id=306 STER_RS08990 WP_002946126.1 1710438..1710764(-) (comGC) [Streptococcus thermophilus LMD-9]
MKLMLKKLNAVKLRAFTLIEMLVVLLIISILLLLFVPNLSKQKDSVKETGNAAVVKVVDSQAELYEMKNNKTASLAALVS
EGQITQKQADSYNDYYAKHGGESRSVAN

Nucleotide

• Length: 327 bp

>NTDB_id=306 STER_RS08990 WP_002946126.1 1710438..1710764(-) (comGC) [Streptococcus thermophilus LMD-9]
ATGAAATTGATGTTAAAAAAATTGAATGCCGTTAAATTACGAGCCTTTACTCTGATTGAAATGCTAGTCGTACTTCTCAT
TATCAGTATTCTCCTTTTGCTCTTTGTTCCTAACTTAAGCAAGCAGAAGGATTCCGTTAAGGAAACTGGAAATGCGGCTG
TAGTCAAGGTCGTGGATTCTCAGGCAGAACTTTATGAAATGAAGAATAACAAGACAGCTAGCTTGGCAGCTCTTGTTTCA
GAAGGTCAAATTACGCAAAAACAGGCAGATTCATACAATGATTACTATGCGAAACATGGTGGTGAAAGCCGCTCAGTGGC
CAATTAG

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (14-34)

3D structure

• AlphaFold DB: A0A0E2Q1B3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus mutans UA140	69.231	96.296	0.667
comYC	Streptococcus mutans UA159	69.231	96.296	0.667
comYC	Streptococcus gordonii str. Challis substr. CH1	63.81	97.222	0.62
comGC/cglC	Streptococcus mitis SK321	62.264	98.148	0.611
comGC/cglC	Streptococcus mitis NCTC 12261	58.333	100	0.583
comGC/cglC	Streptococcus pneumoniae D39	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae R6	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae Rx1	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae TIGR4	58.491	98.148	0.574
comGC	Lactococcus lactis subsp. cremoris KW2	56.604	98.148	0.556
comYC	Streptococcus suis isolate S10	60.227	81.481	0.491
comGC	Staphylococcus aureus MW2	50	72.222	0.361
comGC	Staphylococcus aureus N315	50	72.222	0.361